Bone mineral density in normal Swedish women

Löfman, Owe; Larsson, Laşse; Ross, Ian Louis; Toss, Göran; Berglund, Kenneth

doi:10.1016/s8756-3282(96)00345-6

Cited by 83 publications

(46 citation statements)

References 35 publications

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“…Our results for men and women up to ages 50-60 are generally consistent with the findings of others. 15,17,19,30,31 Our data have important practical clinical implications for the frequency of measuring bone mineral density. Even women aged 50-54, among whom we observed the greatest bone loss, experienced a rate of loss of only 1.3% per year.…”

Section: Discussionmentioning

confidence: 85%

Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

Berger

Langsetmo²,

Joseph

et al. 2008

Canadian Medical Association Journal

132

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Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents Background: Measurement of bone mineral density is the most common method of diagnosing and assessing osteoporosis. We sought to estimate the average rate of change in bone mineral density as a function of age among Canadians aged 25-85, stratified by sex and use of antiresorptive agents. Methods:We examined a longitudinal cohort of 9423 participants. We measured the bone mineral density in the lumbar spine, total hip and femoral neck at baseline in 1995-1997, and at 3-year (participants aged 40-60 years only) and 5-year follow-up visits. We used the measurements to compute individual rates of change.Results: Bone loss in all 3 skeletal sites began among women at age 40-44. Bone loss was particularly rapid in the total hip and was greatest among women aged 50-54 who were transitioning from premenopause to postmenopause, with a change from baseline of -6.8% (95% confidence interval [CI] -7.5% to -4.9%) over 5 years. The rate of decline, particularly in the total hip, increased again among women older than 70 years. Bone loss in all 3 skeletal sites began at an earlier age (25-39) among men than among women. The rate of decline of bone density in the total hip was nearly constant among men 35 and older and then increased among men older than 65. Use of antiresorptive agents was associated with attenuated bone loss in both sexes among participants aged 50-79. Interpretation:The period of accelerated loss of bone mineral density in the hip bones occurring among women and men older than 65 may be an important contributor to the increased incidence of hip fracture among patients in that age group. The extent of bone loss that we observed in both sexes indicates that, in the absence of additional risk factors or therapy, repeat testing of bone mineral density to diagnose osteoporosis could be delayed to every 5 years.

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Section: Discussionmentioning

confidence: 85%

Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

Berger

Langsetmo²,

Joseph

et al. 2008

Canadian Medical Association Journal

132

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“…BMD for Swedish women was compared to different machinespecific reference values published in two previous studies (Lofman et al 1997(Lofman et al , 2000. In general, the BMD values for Swedish women were found to be somewhat lower in both hip and spine, with premenopausal spine BMD being an exception (in that the Swedish values and reference values corresponded well) (Lofman et al 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Subjects with a history of any previous fracture were excluded from the reference group. 209 women (55-75 years old) were included in the reference group (Lofman et al 1997) (Table 1).…”

Section: Reference (Control) Groupmentioning

confidence: 99%

“…The decision to use the machinespecific databases was made to permit comparision between studies. BMD in Swedish women was compared to different machine-specific reference values in two previous studies (Lofman et al 1997(Lofman et al , 2000. In general, the BMD values in Swedish women were found to be somewhat lower in both the hip and spine-with the exception of premenopausal spine BMD, which were no different.…”

Section: Bone Mineral Density Anthropometry and Questionnairementioning

confidence: 99%

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Women with low-energy fracture should be investigated for osteoporosis

et al. 2007

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Introduction Treatment of osteoporosis is becoming more effective, but methods to identify patients who are most suitable for investigation and treatment are still being debated. Should any type of fracture have higher priority for investigation of osteoporosis than any other? Is the number of previous fractures useful information?Material and methods We investigated 303 consecutive women patients between 55 and 75 years of age who had a newly diagnosed low-energy fracture. They answered a questionnaire on previous fractures which also dealt with risk factors. Bone mineral density (BMD) was measured at the hip, lumbar spine, and forearm.Results The distribution of fracture location was: distal forearm 56%, proximal humerus 12%, vertebra 18%, and hip 13%, all with similar age. Half of the subjects had had at least one previous fracture before the index fracture, 19% had had two previous fractures, and 6% had had three or more previous fractures. Patients with vertebral or hip fracture had lower BMD and had had more previous fractures than patients with forearm or humerus fractures. There was an inverse correlation between number of fractures and BMD. Osteoporosis was present in one-third of patients with forearm fracture, in one-half of those with hip or humerus fracture, and in two-thirds of those with vertebral fracture.Interpretation Vertebral fractures were the strongest marker of low BMD and forearm fractures the weakest. The number of previous fractures is helpful information for finding the most osteoporotic patient in terms of severity. Investigation of osteoporosis therefore seems

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“…The NHANES III bone normative data were used as a reference population since these BMD values are considered also to be representative of Swedish women, as shown by Lofman et al (1997).…”

Section: Measurement Of Bmdmentioning

confidence: 99%

Nutritional status, as determined by the Mini-Nutritional Assessment, and osteoporosis: a cross-sectional study of an elderly female population

Salminen

Sääf

et al. 2005

Eur J Clin Nutr

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Objective: To investigate the relationship between osteoporosis and nutritional status as determined by the Mini-Nutritional Assessment (MNA). Design: A cross-sectional study. Setting: Stockholm, Sweden. Subjects: A total of 351 elderly free-living women (mean age 7372.3 years). Methods: MNA (range 0-30 points; o17 indicates malnutrition, 17.5-23.5 risk of malnutrition and X24 well nourished), measurements of bone mineral density of the left hip and lumbar spine using Hologic QDR 4500, and of the heel using Calscan DEXA-T. Results: The median MNA score was 27 (range 12.5-30). One woman was classified as malnourished and 7.4% were at risk of malnutrition. Osteoporosis of the femoral neck was observed in 22% and a fracture after the age of 50 was reported by 31% of the participants. The following items in the MNA questionnaire exhibited an increased risk of having osteoporosis in the femoral neck and/or total hip: an MNA score of o27 (odds ratio (OR) ¼ 2.09; CI ¼ 1.14-3.83); a mid-arm circumference of less than 28 cm (OR ¼ 2.97; CI ¼ 1.29-6.81); and regular use of more than 3 drugs each day (OR ¼ 2.12; CI ¼ 1.00-4.50). A body weight of more than 70 kg exhibited a decreased risk of having osteoporosis (OR ¼ 0.31; CI ¼ 0.14-0.70). Conclusions: In general, the nutritional status was good in this population of free-living elderly women. Nevertheless, half of the women who displayed an MNA score o27 points had a twofold increased risk of having osteoporosis.

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Bone mineral density in normal Swedish women

Cited by 83 publications

References 35 publications

Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

Women with low-energy fracture should be investigated for osteoporosis

Nutritional status, as determined by the Mini-Nutritional Assessment, and osteoporosis: a cross-sectional study of an elderly female population

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