Bone Metabolism and Bone Mineral Density in Premenopausal Women with Mild Depression

Kavuncu, Vural; Kuloğlu, Murat; Kaya, Arzu; Şahin, Sezai; Atmaca, Murad; Firidin, Burak

doi:10.3349/ymj.2002.43.1.101

Cited by 31 publications

(46 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The majority of analyses have replicated the original 1994 finding of Schweiger et al lower BMD among persons with depression or depressive symptoms relative to comparison groups [7][8][9][10][11][12][13][14][15][16][17][18]. However, seven studies have not found a statistically significant association between depression or depressive symptoms and lower BMD [19][20][21][22][23][24][25]. These studies are discussed below under their respective study designs.…”

Section: Depression Depressive Symptoms and Osteoporosissupporting

confidence: 48%

“…The case-control study by Amsterdam and Hooper (1995) had limited power to detect an effect given the small sample size (N=11) [20]. Similarly, the studies by Kavuncu et al (2002) and Yazici et al (2005) were limited to young pre-menopausal women (mean age of depressed group: 35.4 years and 44.8 years, respectively). Many of these women had not yet passed through the peak developmental period of risk for depression (age 30-45) [27], and thus the cases of depression in these reports may not have been representative of the depression in the general population.…”

Section: Case-control Studiesmentioning

confidence: 99%

“…As with the cross-sectional reports, results were inconsistent across these case-control analyses. Three of the ten case-control studies reported no association between depression or depressive symptoms and BMD [20,21,25]. Each of these studies had important limitations that should be taken into account when evaluating the evidence for this relationship.…”

Section: Case-control Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Depression and osteoporosis: epidemiology and potential mediating pathways

2007

View full text Add to dashboard Cite

Introduction-There have been numerous studies examining the association between depression and bone mineral density (BMD), but the underlying nature of this relationship remains unclear. Independent of this association, there is a growing body of evidence that depression impacts the risk for fracture in older adults. This article reviews the current epidemiological evidence regarding comorbidity of depression, low bone mineral density, and fracture.

show abstract

Section: Depression Depressive Symptoms and Osteoporosissupporting

confidence: 48%

Section: Case-control Studiesmentioning

confidence: 99%

Section: Case-control Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Depression and osteoporosis: epidemiology and potential mediating pathways

2007

View full text Add to dashboard Cite

show abstract

“…Menopause, aging, deficient calcium and vitamin D intake, smoking, alcohol use, immobility, drugs, hormonal and renal diseases have been suggested for the etiology of OP [4][5][6]. In recent years major depression has been also demonstrated as a risk factor in the development of OP [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Bone mass and bone turnover in premenopausal women with fibromyalgia syndrome

Gürbüz¹,

Kaya²,

Balcı³

2017

Med-Science

Self Cite

View full text Add to dashboard Cite

In this study, we aimed to compare osteoporosis (OP)-related bone mineral density, and bone turnover (markers of formation, and resorption) between patients with Fibromyalgia Syndrome (FMS) and degenerative disc disease, and to determine the relationship of these parameters with clinical, functional and emotional evaluation outcomes in FMS. Fifty premenopausal women with FMS and 50 premenopausal female control patients with degenerative disc disease were enrolled. The patient and physician's global assessment of disease were assessed on a visual analog scale (VAS). Disease severity was determined with the Fibromyalgia Impact Questionnaire (FIQ). For the evaluation of fatigue The Modified Fatigue Impact Scale (MFIS) and Fatigue Severity Scale (FSS) were used. The quality of life of all patients was evaluated using Nottingham Health Profile (NHP), Oswestry Disability Index (ODI), and QUALEFFO-41. The emotional state of all patients with chronic pain was evaluated with Hospital Anxiety and Depression Scale (HADS). Bone turnover markers [serum bone-specific alkaline phosphatase (bALP) and serum osteocalcin as markers of bone formation, serum â-isomerized Carboxy-terminal telopeptide of collagen type I (â-CTX) and urine hydroxyproline (OH-Pro) as markers of bone resorption], serum parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] levels, lumbar spine and left proximal femur bone mineral density (BMD) and T scores were measured in both groups. The FIQ, MFIS, FSS, NHP, ODI, QUALEFFO-41, HADS-A and HADS-D scores were statistically significantly higher in the FMS group relative to the patient control group. A significant difference between FMS and patient control group as for bone formation (bALP and osteocalcin) and resorption (â-CTX ve OH-Pro) markers was not detected. In the FMS group lumbar spine and left proximal femur BMD and T score values were significantly lower when compared with the patient control group. In the FMS group significant correlations were found between serum 25(OH)D and â-CTX values and VAS scores evaluated by the patient and physician, SS scale, FIQ, MFIS, ODI, QUALEFFO-41 and NHP scores. In conclusion many factors including depression and anxiety attacks, the presence of widespread pain and a decline in physical activity level and quality of life in FMS patients make them more prone to osteoporosis. In patients with FMS, osteoporosis is a major cause of morbidity and should not be neglected.

show abstract

“…Several investigations reported no difference in serum markers of bone turnover, including osteocalcin, bone-specific alkaline phosphatase and telopeptide (C-and N-terminal), in depression cases compared with controls, even when differences in BMD were found [25][26][27][28][29][30]. With few exceptions [24,29], the majority of studies have reported no difference between depression cases and controls concerning calcium metabolism indicated by levels of parathyroid hormone or 25-OH vitamin D levels [25,27,28,30,31]. The inconsistency of the existing evidence regarding depression and markers of bone turnover probably stems from issues pertaining to study design, including small sample sizes and differing sample composition, the lack of longitudinal analyses or studies in men, and the risk of residual confounding from unaccounted variables, including psychotropic medication use and chronic medical conditions.…”

mentioning

confidence: 99%