Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: Role of heme oxygenase-adiponectin

Abraham, Nader G.; Li, Ming; Vanella, Luca; Peterson, Stephen J.; Ikehara, Susumu; Asprinio, David E.

doi:10.1016/j.jaut.2007.12.005

Cited by 51 publications

(28 citation statements)

References 70 publications

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“…6A, B). Induction of HO-1 in bone marrow has been reported to have a beneficial effect on the hematopoietic microenvironment, including MSCs (54,55).…”

Section: Discussionmentioning

confidence: 99%

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

Peterson

Drummond

Kim

et al. 2008

Journal of Lipid Research

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148

167

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We hypothesized that the apolipoprotein mimetic peptide L-4F, which induces arterial anti-oxidative enzymes and is vasoprotective in a rat model of diabetes, would ameliorate insulin resistance and diabetes in obese mice. L-4F (2 mg/kg/d) administered to ob/ob mice for 6 weeks limited weight gain without altering food intake, decreased visceral (P , 0.02) and subcutaneous (P , 0.045) fat content, decreased plasma IL-1b and IL-6 levels (P , 0.05) and increased insulin sensitivity, resulting in decreased glucose (P , 0.001) and insulin (P , 0.036) levels. In addition, L-4F treatment increased aortic and bone marrow heme oxygenase (HO) activity and decreased aortic and bone marrow superoxide production (P , 0.001). L-4F treatment increased serum adiponectin levels (P , 0.037) and decreased adipogenesis in mouse bone marrow (P , 0.039) and in cultures of human bone marrow-derived mesenchymal stem cells (P , 0.022). This was manifested by reduced adiposity, improved insulin sensitivity, improved glucose tolerance, increased plasma adiponectin levels, and reduced IL-1b and IL-6 levels in obese mice. This study highlights the existence of a temporal relationship between HO-1 and adiponectin that is positively affected by L-4F in the ob/ob mouse model of diabetes, resulting in the amelioration of the deleterious effects of diabetes.-Peterson,

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“…6A, B). Induction of HO-1 in bone marrow has been reported to have a beneficial effect on the hematopoietic microenvironment, including MSCs (54,55).…”

Section: Discussionmentioning

confidence: 99%

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

Peterson

Drummond

Kim

et al. 2008

Journal of Lipid Research

Self Cite

148

167

View full text Add to dashboard Cite

show abstract

“…Previous reports indicated that multipotent stem cells could promote healing of type 2 diabetic ischemic limbs [22][23][24]. Some researchers investigated the effects of stem cells on T2DM [25][26][27]. Bhansali et al [28] treated ten patients with T2DM by autologous bone marrow stem cell transplantation, and noted no serious adverse effects indicating that stem cell transplantation is a safe and effective method of improving beta-cell function in patients with T2DM.…”

Section: Figmentioning

confidence: 99%

Long term effects of the implantation of autologous bone marrow mononuclear cells for type 2 diabetes mellitus

Wang

et al. 2012

Endocr J

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“…porting the existence of a HO-1-adiponectin axis that is critical in vascular protection (11,84,95,106,146). Therefore, upregulation of HO-1, accompanied by an increase in HO activity and the concomitant induction of adiponectin, may play an important role in normalizing hypertension.…”

Section: Role Of Ho In Blood Pressure Regulationmentioning

confidence: 99%

Heme oxygenase: the key to renal function regulation

Abraham

Cao

Sacerdoti

et al. 2009

American Journal of Physiology-Renal Physiology

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Heme oxygenase (HO) plays a critical role in attenuating the production of reactive oxygen species through its ability to degrade heme in an enzymatic process that leads to the production of equimolar amounts of carbon monoxide and biliverdin/bilirubin and the release of free iron. The present review examines the beneficial role of HO-1 (inducible form of HO) that is achieved by increased expression of this enzyme in renal tissue. The influence of the HO system on renal physiology, obesity, vascular dysfunction, and blood pressure regulation is reviewed, and the clinical potential of increased levels of HO-1 protein, HO activity, and HO-derived end products of heme degradation is discussed relative to renal disease. The use of pharmacological and genetic approaches to investigate the role of the HO system in the kidney is key to the development of therapeutic approaches to prevent the adverse effects that accrue due to an impairment in renal function.

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Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: Role of heme oxygenase-adiponectin

Cited by 51 publications

References 70 publications

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

Long term effects of the implantation of autologous bone marrow mononuclear cells for type 2 diabetes mellitus

Heme oxygenase: the key to renal function regulation

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