Bone Marrow Derived Mesenchymal Stem Cells As A Therapy for Renal Injury.

Zahran, Faten; Elghareb, Mohamed S.; Nabil, Ahmed

doi:10.15373/2249555x/apr2014/3

Cited by 3 publications

(4 citation statements)

References 47 publications

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“…Recently, many studies have focused on the excellent regenerative potential of BM-MSCs and their capabilities of repairing injured tissues and dampening the inflammatory responses of various tissues [ 22 , 23 ]. BM-MSCs have paracrine therapeutic activities, mainly through trophic factors [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

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The Combined Effect of Licorice Extract and Bone Marrow Mesenchymal Stem Cells on Cisplatin-Induced Hepatocellular Damage in Rats

et al. 2023

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Drug-induced liver damage is a life-threatening disorder, and one major form of it is the hepatotoxicity induced by the drug cisplatin. In folk medicine, Licorice (Glycyrrhiza glabra (is used for detoxification and is believed to be a potent antioxidant. Currently, the magically self-renewable potential of bone marrow mesenchymal stem cells (BM-MSCs) has prompted us to explore their hepatoregenerative capability. The impact of G. glabra extract (GGE) and BM-MSCs alone and, in combination, on protecting against hepatotoxicity was tested on cisplatin-induced liver injury in rats. Hepatic damage, as revealed by liver histopathology and increased levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and malondialdehyde (MDA), was elevated in rats by received 7 mg/kg of cisplatin intraperitoneally. The combination of GGE and BM-MSCs returned the enzyme levels to near the normal range. It also improved levels of liver superoxide dismutase (SOD) and glutathione (GSH) and reduced MDA levels. Additionally, it was found that when GGE and BM-MSCs were used together, they significantly downregulated caspase9 (Casp9), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), and interleukin-1β (IL-1β), which are involved in severe proinflammatory and apoptotic signaling cascades in the liver. Moreover, combining GGE and BM-MSCs led to the normal result of hepatocytes in several examined liver histological sections. Therefore, our findings suggest that GGE may have protective effects against oxidative liver damage and the promising regenerative potential of BM-MSCs.

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Section: Discussionmentioning

confidence: 99%

“…Their abilities to proliferate, establish daughter cell lines, and repair injured tissues are of great interest to researchers [ 22 ]. Another advantage is their ability to dampen the inflammatory responses of various tissues [ 23 ]. The therapeutic effects of BM-MSCs are caused by many different stromal cells.…”

Section: Introductionmentioning

confidence: 99%

The Combined Effect of Licorice Extract and Bone Marrow Mesenchymal Stem Cells on Cisplatin-Induced Hepatocellular Damage in Rats

et al. 2023

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“…Furthermore, MSCs were able to document homing and repair the injured kidney through (1) anti-inflammatory cytokine secretion like TGFβ1 to limit apoptosis and dampen the inflammatory response, (2) differentiation into tubular epithelial cells, (3) lipid peroxidation reduction, and (4) marked increase in antioxidant levels. In addition, many reports suggest that the antioxidant potential of DPPD could inhibit renal interstitial fibrosis and nephrotoxicity induced by either cisplatin (Kawai et al, 2009) or HgCl 2 (Zahran et al, 2014;Nabil et al, 2020). This was by targeting the collagen deposition and the hepatorenal fibrosis progression, either directly through renal fibrogenesis or indirectly via decreasing ROS production.…”

Section: Kidney Functionsmentioning

confidence: 99%

The potency of , -diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

M. ABD EL-LATEEF,

H. QAHL,

FAYAD

et al. 2023

Biocell

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Background: The increasing occurrence of diabetes mellitus (DM) noted worldwide has considerably elicited concern in the recent past. DM is associated with elevated vascular complications, morbidity, mortality, and poor quality of life. In this context, mesenchymal stem cells (MSCs) have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable, immunosuppressive, and differentiation capacities. We investigated the potential action of N, N′-diphenyl-1,4-phenylenediamine (DPPD), a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells (AD-MSCs) in alleviating kidney and liver complications in diabetic rats. Methods: Over the four weeks of experiments, albino male rats (n = 36) were split into six test groups: control, DPPD (250 mg/kg, i.p.), STZ-diabetic (D), D+DPPD, D+AD-MSCs (1 × 10 6 cell/rat, i.v.), and D+AD-MSCs +DPPD treated groups. Results: Significant declines in the renal and hepatic oxidative stress markers (MDA, ROS, and AGEs) were observed coupled with a significant elevation in many antioxidant marker levels (GSH, SOD, CAT, GPx, HO-1, and TAC) in the diabetic rats treated with either DPPD or AD-MSCs or their co-administered injection compared to the diabetic untreated rats. This was suggested to be the leading cause of amelioration of the kidney functions (as measured by urea, uric acid, and creatine levels) and liver functions (as evidenced by the levels of AST, ALT, ALP, bilirubin, total proteins, albumin, and globulins). Conclusion: DPPD and AD-MSCs co-administration showed superior results in terms of the enhancement of the relative hepato-renal function, indicating the beneficial role of DPPD supplementation in increasing the therapeutic potential of AD-MSCs.

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“…Their ease of isolation, manipulability and potential for differentiation are specifically what has made them so attractive [14]. MSCs can repair the injured kidney through variable mechanisms where stem cells are able to make Homing to the injured kidney and secretion of anti-inflammatory cytokines like dampen the inflammatory response also it differentiate into tubular epithelial cells [15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Antioxidants and Mesenchymal Stem Cells on Cisplatin Induced Renal Fibrosis in Rats

Nabil¹

2016

JSRT

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Bone Marrow Derived Mesenchymal Stem Cells As A Therapy for Renal Injury.

Cited by 3 publications

References 47 publications

The Combined Effect of Licorice Extract and Bone Marrow Mesenchymal Stem Cells on Cisplatin-Induced Hepatocellular Damage in Rats

The Combined Effect of Licorice Extract and Bone Marrow Mesenchymal Stem Cells on Cisplatin-Induced Hepatocellular Damage in Rats

The potency of , -diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

Effect of Antioxidants and Mesenchymal Stem Cells on Cisplatin Induced Renal Fibrosis in Rats

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