Bone Lesions of Urticaria Pigmentosa in Childhood

Paediatric mastocytosis: a systematic review of 1747 cases

“…Outcome data were available for 621 cases (36%; Fig. g–i) . Clinical outcome was described by three teams …”

“…In total 90 articles were available. This included 43 series, 21 case reports with outcome data (> 3 years), 15 articles involving twins (one of which was also included in the 43 series), corresponding to 31 cases and 12 articles concerning MCL or MCS, corresponding to 12 cases (two concerning the same patients) . A two‐generation history of mastocytosis was mandatory for the positive familial history criterion.…”

Mastocytosis. Report of a case in a 15 and one-half-week-old infant with cutaneous and generalized skeletal changes.

“…Of these, 9 showed solitary or localized skeletal lesions (Asboe-Hansen, 1953;Grupper, 1954;Shair and Casper, 1955;Gulden and Niebauer, 1956;Edelstein, 1956;Remy, 1957;Hasselmann and Scholder-Oehmichen, 1957;Lees and Stroud, 1959;Niordson, 1962); and 3 showed the generalized type of skeletal lesion, the youngest of whom was 2 years old (Rider et al, 1957;Lees and Stroud, 1959). The case reported here appears to be the youngest to show generalized skeletal lesions, and is unusual in that the radiographic changes completely disappeared by 17 months of age.…”

“…However, since Ellis (1949) described a necropsy on a fatal case in a male infant, showing the invasion of many organs by mast cells, and Sagher, Cohen, and Schorr (1952), Sagher, Liban, Ungar, and Schorr (1956), and Sagher and Schorr (1956) noted the radiographic changes associated with this condition, the interest has spread to radiologists, hospital doctors, and paediatricians (Marshall et al, 1957;Rider, Stein, and Abbuhl, 1957;Waters and Lacson, 1957;Lees and Stroud, 1959;Poppel, Gruber, Silber, Holder, and Christman, 1959;Stutzman, Zsoldos, Ambrus, and Asboe-Hansen, 1960;Stutzman and Urbach, 1961;Bigelow, 1961;Szweda, Abraham, Fine, Nixon, and Rupe, 1962;Pastras and Beerman, 1962).…”

Involvement of the small intestine in systemic mast cell disease.

“…Interestingly, both patients responded clinically and histologically to a glutenfree diet and must therefore be considered to have coeliac disease. Furthermore, there is another patient who probably also had systemic mast cell disease and coeliac disease (Lees and Stroud, 1959) although histological details were not given. All of the above patients were said to have typical urticaria pigmentosa except the patient of Rubin and Dobbins (1965) in whom this is presumed.…”