Bone diminution of osteoporotic females at different skeletal sites

Mautalén, C.; Vega, Eduardo; Ghiringhelli, G; Fromm, Günther A.

doi:10.1007/bf02554998

Cited by 43 publications

(7 citation statements)

References 15 publications

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“…The results obtained in normal women were similar in both centres (18,19) and not dif¬ ferent from the results obtained in other Caucasian pop¬ ulations (20,21). Since the average bone mineral density of the lumbar spine in normals was not different in both centres, the results obtained in Sao Paulo and Buenos Aires were analysed together.…”

Section: B One Measurementsmentioning

confidence: 78%

Bone mass in totally thyroidectomized patients. Role of calcitonin deficiency and exogenous thyroid treatment

Anseán¹,

Mautalén²,

Corrêa

et al. 1991

Acta Endocrinologica

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Calcitonin has an uncertain role in the preservation of bone mass. Since surgical thyroidectomy abolishes the calcitonin secretion in response to calcium, the bone mineral density at the radius shaft and lumbar spine was measured in 60 patients (5 men, 16 premenopausal, 34 postmenopausal euparathyroid and 5 postmenopausal hypoparathyroid women) who had undergone near total thyroidectomy for thyroid cancer 8.4\m=+-\0.7 years before the study. All patients were maintained on suppressive doses of thyroid hormones. Bone mineral density values of the radius shaft (expressed as Z-score) of 34 postmenopausal euparathyroid women was significantly below the normal average (mean \m=+-\sem = \ m= -\ 0 . 5 9 \m=+-\0.2; p=0.01). Bone mineral density of the lumbar spine was also below the normal average although the difference only approached statistical significance (\m=-\0.36\m=+-\0.2; 0.05

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Section: B One Measurementsmentioning

confidence: 78%

Bone mass in totally thyroidectomized patients. Role of calcitonin deficiency and exogenous thyroid treatment

Anseán¹,

Mautalén²,

Corrêa

et al. 1991

Acta Endocrinologica

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“…While it is in general presumed that osteoporosis is the main cause of reduced bone strength, there is no clear biomodality in the distribution of measured mineral density in the population, and values overlap widely for age-and sex-matched individuals with and without vertebral fractures [8,29,30,32,49]. Apparantly, there are other factors than bone mass only that account for biomechanical stability.…”

Section: Discussionmentioning

confidence: 99%

Architecture and distribution of cancellous bone yield vertebral fracture clues

Amling

Pösl

Ritzel

et al. 1996

Arch Orthop Trauma Surg

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The objective of this study was to analyze the structure of cancellous bone and its significance for vertebral fractures. Therefore, the complete spinal column from 40 autopsy cases (18 without diseases affecting the skeleton and 12 osteoporotic) was removed and sectioned in the sagittal plane to a thickness of 1 mm. A surface-stained block grinding technique allowed combined two- and three-dimensional histomorphometric analysis, which included an evaluation of the trabecular bone volume (BV/TV, in %) and the trabecular interconnection (TBPf, in mm). In addition, qualitative investigation of the structure of trabecular bone was done. The distribution of trabecular bone volume within the spinal column of a normal skeleton shows a curve, with the highest values in the cervical spine and a decline in the thoracic and lumbar spine. Osteoporosis presents itself with a pathologically diminished trabecular bone volume, whereas the distribution within the spine is comparable to that of the controls. Osteoporotic patients show an apparently reduced trabecular interconnection. It is important that the measured values for TBPf are not only in general higher, but also more widely dispersed. The age-related decrease of trabecular bone mass is due to the transformation from plates to rods. This is quantitatively indicated by the close correlation of BV/TV and TBPf (P < 0.001, r = 0.85). The bone loss in osteoporosis is a loss of structure and a loss of whole trabeculae, which is caused by perforations. It involves a gradual change from normal bone. However, the polyostic heterogeneity in osteoporosis is immense. These structural differences demonstrate the development of regions of least resistance within the spine, serving as an explanation of osteoporotic fractures. Due to the polyostotic heterogeneity it is impossible to define a threshold mineral content for crash fractures by diagnostic measurements at any reference site.

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“…This deficit is often greatest at the fracture site. For example, women with spine fractures have lower spine than hip aBMD, women with femoral neck fractures have lower femoral neck than spine aBMD, and women with distal radial fractures have greater deficits at the radius than at other sites (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%