Bone density of the midpalatal suture 7 months after surgically assisted rapid palatal expansion in adults

Recombinant human bone morphogenetic protein-2 stimulates bone formation during interfrontal suture expansion in rabbits

“…8,18,19 Ideal suture expansion methods would include rapid expansion and accelerated consolidation. The use of optimal tensional force combined with an appropriate concentration of rhBMP-2 might make this method possible.…”

Effects of Platelet-Rich Plasma and Recombinant Human Bone Morphogenetic Protein-2 on Suture Distraction Osteogenesis

“…The clinical application of this treatment approach has, however, been hampered by a long retention period and a high relapse tendency. 18,21,22 Increasing the distraction rate or force, together with local application of growth factors to the distraction site to stimulate new bone formation, is an evolving approach to accelerating bone formation, shortening the retention period and decreasing the rate of relapse.…”

Stimulation of bone formation in the expanding premaxillary suture with a GSK‐3β inhibitor

“…Although the mode of action of RPE is associated with alveolar bone bending and dental tipping, the major goal of such growth modification is to distract the maxillary halves, allowing for new bone deposition in the expanded midpalatal suture (Garrett et al , 2008). RPE was originally advocated for use in growing adolescents where the sutures remain patent, and now it has been successfully adopted in skeletally mature adults with the aid of surgery (Petrick et al , 2011). Unfortunately, these treatments are accompanied by relapse of some extend (Lima et al , 2005; Gurel et al , 2010).…”

“…Multiple reasons for post‐treatment relapse of RPE have been identified, including circummaxillary resistance, soft‐tissue adaptation, and age (Baccetti et al , 2001; Lagravere et al , 2005). Recent studies using computed tomography demonstrated that bone mineralization in the expanding midpalatal suture is not completed after a conventional 6‐month retention period (da Silva Filho et al , 2006; Petrick et al , 2011). Inadequate bone formation in the suture could lead to early relapse because the suture cannot withstand the tension and pressure of facial bone structures (Sarnas et al , 1992; Petrick et al , 2011).…”

“…Recent studies using computed tomography demonstrated that bone mineralization in the expanding midpalatal suture is not completed after a conventional 6‐month retention period (da Silva Filho et al , 2006; Petrick et al , 2011). Inadequate bone formation in the suture could lead to early relapse because the suture cannot withstand the tension and pressure of facial bone structures (Sarnas et al , 1992; Petrick et al , 2011). Therefore, to prevent relapse and shorten the retention period, enhancement of new bone formation in the suture after RPE would be beneficial.…”