Bonding of microfluidic devices fabricated in polycarbonate

Ogończyk, Dominika; Węgrzyn, Judyta; Jankowski, Paweł; Dąbrowski, B.; Garstecki, Piotr

doi:10.1039/b924439e

Cited by 148 publications

(94 citation statements)

References 26 publications

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“…In all these trials, we used the optimized procedure of modification: we used 20 9 40 mm PC plates of a thickness of 0.75 mm. Cleaned PC plates were swelled in vacuum with dichloromethane vapors and heated in an oven at 130°C for 30 min prior to use to mimic the conditions of the sealing process (Ogończyk et al 2010). Then we treated them with a 10 % (w/w) ethanol solution of SnCl 2 at 70°C for 2 h and then thoroughly washed with water and dried with pressurized air.…”

Section: Stability Of the Modificationmentioning

confidence: 99%

Hydrophilic polycarbonate chips for generation of oil-in-water (O/W) and water-in-oil-in-water (W/O/W) emulsions

Jankowski

Ogończyk

Derzsi

et al. 2012

Microfluid Nanofluid

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Modification of the surfaces of polycarbonate (PC) with the use of a solution of tin (II) chloride renders them hydrophilic. The surface draping is stable against exposure to water and to alcohols. Exposure to alkanes reduces but does not diminish the effect. The method is compatible-in using the same solvent and temperature-with the hydrophobic modification of PC Jankowski et al. ( Lab Chip 11:748-752, 2011). The combination of these methods makes it possible to generate single and multiple monodisperse emulsions with the use of flow-focusing junctions in systems made in PCmaterial that is suitable for fabrication of multilayer, high throughput microfluidic devices.

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Section: Stability Of the Modificationmentioning

confidence: 99%

Hydrophilic polycarbonate chips for generation of oil-in-water (O/W) and water-in-oil-in-water (W/O/W) emulsions

Jankowski

Ogończyk

Derzsi

et al. 2012

Microfluid Nanofluid

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“…The CNC machine has a reproducibility of positioning of 5 μm and allows for using milling bits as small as 100 μm in diameter. We bounded the milled microchip with a flat slab of polycarbonate using method elaborated by Ogoń-czyk et al [80].…”

Section: Discussionmentioning

confidence: 99%

Scaling up the Throughput of Synthesis and Extraction in Droplet Microfluidic Reactors

et al. 2015

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Conducting reactions in droplets in microfluidic chips offers several highly attractive characteristics, among others, increased yield and selectivity of chemical syntheses. The use of droplet microfluidic systems in synthetic chemistry is, however, hampered by the intrinsically small throughput of micrometric channels. Here, we verify experimentally the potential to increase throughput via an increase of the scale of the channels. We use the results of these experiments characterizing the processes of (1) generation of droplets, (2) mixing in droplets, (3) inter-phase extraction, and (4) the yield of synthesis of pyrrole, to postulate a number of guidelines for scaling up the throughput of microfluidic droplet systems. In particular, we suggest the rules for maximizing the throughput via an increase of the size of the channels and via parallelization to optimize the throughput of synthesis against the cost of fabrication of the chips and against the kinetic requirements of specific reactions.

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“…The most common thermoplastics used for the fabrication of microfluidic chips are the following materials: polycarbonate (PC) (Ogończyk et al, 2010), polymethylmethacrylate (PMMA) (Conchouso et al, 2014), cyclic-olefin copolymers (COC) (Stachowiak et al, 2007), polystyrene (PS) (Li et al, 2012), polytetrafluoroethylene (PTFE, also known under the brand name Teflon ® ), fluorinated ethylene propylene (FEP) (Horka et al, 2016). Prototyping in thermoplastics is usually done by i) micromilling the channels in the plate and bonding it to another plate (Ogończyk et al, 2010); or by ii) 3D printing the appropriate polymer, e.g. methacrylate-based photoresist, in the shape of the microfluidic device (Femmer et al, 2015).…”

Section: Prototyping Methodsmentioning

confidence: 99%

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Opalski

Kamiński

Garstecki

2019

KONA

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Emulsion-a liquid dispersed in another liquid-is in many respects very similar to granular matter. In the early 2000s a new technology-droplet microfluidics-began emerging from the wider field of microfluidics. Droplet microfluidics was quickly established as a discipline of science and engineering and has been used for the generation of highly uniform emulsions. The last few years have brought significant advances to the field, directed towards a wide range of applications in material sciences-from synthesis of nanoparticles in droplets to assembling complex droplets and using droplets as templates for ordered materials, with applications in food, cosmetic and diagnostic industries. Droplet microfluidic platforms are also successfully used as analytical tools in molecular biology and biochemistry, in e.g. high-throughput screening, digital assays, encapsulation of single cells, sequencing technologies, and in point-of-care diagnostic applications. This article provides an accessible overview of the physical phenomena observed in multiphase flow at the microscale and the techniques in droplet microfluidics systems. We also present the most interesting applications and potential further directions of research in this fascinating young field of science and engineering.

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Bonding of microfluidic devices fabricated in polycarbonate

Abstract: A simple method for bonding polycarbonate, based on controlled exposure of the pieces to vapours of solvents, yields a tight seal and unmodified geometry of the channels.

Cited by 148 publications

References 26 publications

Hydrophilic polycarbonate chips for generation of oil-in-water (O/W) and water-in-oil-in-water (W/O/W) emulsions

Hydrophilic polycarbonate chips for generation of oil-in-water (O/W) and water-in-oil-in-water (W/O/W) emulsions

Scaling up the Throughput of Synthesis and Extraction in Droplet Microfluidic Reactors

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

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