Bolaamphiphilic molecules: Assembly and applications

Interaction between a cationic bolaamphiphile and DNA: The route towards nanovectors for oligonucleotide antimicrobials

“…Bolaform surfactants are known to self-assemble in solution, leading to a wide range of aggregate morphologies depending on their chemical structure: tubules, fibers, ribbons, micelles and vesicles are among the common nano-and micrometric supramolecular structures reported for bolaamphiphiles [20]. For samples more dilute than 4.5 10 -4 mol/L, the scattering intensity was only slightly higher than that of pure water.…”

The Headgroup (A)Symmetry Strongly Determines the Aggregation Behavior of Single-Chain Phenylene-Modified Bolalipids and Their Miscibility with Classical Phospholipids

“…This stabilizing approach was adopted from naturally occurring archaebacterial membrane lipids 4,25,26 and its applicability to drug delivery systems for pharmaceutical purposes was confirmed for a variety of natural and artificial bolalipids. [27][28][29][30][31][32][33][34] In our study we combine both, alkyl chain modifications and the introduction of headgroup asymmetry. At first, we synthesized two novel single-chain bolalipids, namely PC-C17pPhC17-PC and PC-C17pPhC17-OH.…”

Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile

“…Cryo-TEM has been used to probe the change of self-assembled nanostructures. 18,19 Representative Cryo-TEM images from 0.1 wt% EFL 4 To get deeper structural information, we performed in situ 5 synchrotron SAXS experiments. The SAXS curves in Fig.2A for solutions in the range (0.1-1) wt% EFL 4 FE show different features according to peptide concentration.…”