Body weight gain and diurnal differences of corticosterone changes in response to acute and chronic stress in rats

Retana‐Márquez, Socorro; Bonilla-Jaime, Herlinda; Vázquez-Palacios, Gonzalo; Domı́nguez-Salazar, Emilio; Martínez‐García, Rafael; Velázquez‐Moctezuma, Javier

doi:10.1016/s0306-4530(02)00017-3

Cited by 128 publications

(105 citation statements)

References 64 publications

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“…These variations (early morning maximum, declining levels throughout the day, a quiescent period of minimal secretory activity around midnight, and an abrupt elevation during late sleep) are well-known. However, negative daily events and stress have been found to affect diurnal patterns of stress hormone levels as shown by a drop of values below 'normal' following an increase of values above 'normal' [18,19]. The opposite interactive effects on moods of daytime vs. nighttime stress hormones may be explained by an enhanced inhibitory or negative feedback mechanism in higher distress conditions [19,36].…”

Section: Discussionmentioning

confidence: 99%

“…Although a substantial literature has identified increased stress hormone levels in populations reporting high levels of distress [8,9,10] and in clinically depressed patients [11,12]; other investigations have not shown these associations [13,14,15] or have reported effects in the opposite direction [16,17]. Inconsistencies in findings may be a function of different methods of sampling hormone levels [18] or differences in the kinds of acute and chronic stressful events studied [19]. With morning samples, the relationship between stress hormones and affective states was positive [20,21,22], whereas daytime or evening samples showed a negative relationship to distress onset (anxious or depressed moods) and poor performance [17,23], at least for cortisol and norepinephrine.…”

Section: Introductionmentioning

confidence: 98%

“…With morning samples, the relationship between stress hormones and affective states was positive [20,21,22], whereas daytime or evening samples showed a negative relationship to distress onset (anxious or depressed moods) and poor performance [17,23], at least for cortisol and norepinephrine. Distress may affect not only absolute hormone levels but also the diurnal profile of hormone release [18,19]. In contrast to acute stress, in prolonged occupational stress the circadian stress hormone rhythm decreases below minimum levels [24].…”

Section: Introductionmentioning

confidence: 99%

“…We focused on moods that from the literature seem relevant to women's biological and behavioral conditions. In view of the findings that stress-related hormonal activation can not only accompany but can also follow mood changes [16,19], samples of stress hormones (epinephrine, norepinephrine, cortisol) were obtained both at the end of the day and at the end of the nighttime period following the day in which the mood ratings were obtained.…”

Section: Introductionmentioning

confidence: 99%

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Moods in everyday situations: effects of menstrual cycle, work, and stress hormones

Davydov¹,

Shapiro

Goldstein

et al. 2005

Journal of Psychosomatic Research

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Objective: This study examined women's mood responsiveness on work and off days during different phases of the menstrual cycle. Methods: Self reports of negative, positive, and energy dimensions of mood were obtained throughout the day on two work and two off days during the luteal and follicular phases of the menstrual cycle in 203 women nurses. Individual differences in daytime and nighttime epinephrine, norepinephrine, and cortisol were assessed. Results: High daytime norepinephrine, epinephrine, and cortisol levels were associated with higher ratings of stress and tired, and with lower ratings of happy. Phase of the menstrual cycle and the day factor (work day, off day) were also associated with mood differences, and the direction of the effects depended on hormone levels and hormone sampling period. Conclusion: The experience of moods is affected by arousalrelated interaction of hormone levels with phase of the menstrual cycle and occupational stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Moods in everyday situations: effects of menstrual cycle, work, and stress hormones

Davydov¹,

Shapiro

Goldstein

et al. 2005

Journal of Psychosomatic Research

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“…This transient effect may be owing to the timing of the exposure to stressors, ie juvenility, close to their growth spurt at 4-5 weeks (Spear, 2000), which may have overshadowed any stress-related body weight reduction. Alternatively, the lack of a longterm effect on body weight may be due to the fact that stress-related reductions in body weight are prevalent following chronic stress procedures (eg Bekris et al, 2005;Cordero et al, 2005), but not following acute stress procedures (eg Mizoguchi et al, 2001;Retana-Marquez et al, 2003). Mizoguchi et al (2001) suggested that this difference might be associated with the differential effects these procedures have on HPA axis responses.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Stressors during Juvenility Disrupts Development-Related Alterations in the PSA-NCAM to NCAM Expression Ratio: Potential Relevance for Mood and Anxiety Disorders

Tsoory

Guterman

Richter‐Levin

2007

Neuropsychopharmacol

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Childhood trauma is associated with higher rates of both mood and anxiety disorders in adulthood. The exposure of rats to stressors during juvenility has comparable effects, and was suggested as a model of induced predisposition for these disorders. The neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM are critically involved in neural development, activity-dependent synaptic plasticity, and learning processes. We examined the effects of exposure to stressors during juvenility on coping with stressors in adulthood and on NCAM and PSA-NCAM expression within the rat limbic system both soon after the exposure and in adulthood. Exposure to stressors during juvenility reduced novel-setting exploration and impaired two-way shuttle avoidance learning in adulthood. Among naive rats, a development-related decrease of about 50% was evident in the PSA-NCAM to NCAM expression ratio in the basolateral amygdala, in the CA1 and dentate gyrus regions of the hippocampus, and in the entorhinal cortex. In juvenile-stressed rats, we found no such decrease, but rather an increase in the polysialylation of NCAM (B50%), evident soon after the exposure to juvenile stress and also in adulthood. Our results suggest that exposure to stressors during juvenility alters the maturation of the limbic system, and potentially underlies the predisposition to exhibit stress-related symptoms in adulthood.

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Pharmacokinetic/Pharmacodynamic Modeling of Corticosterone Suppression and Lymphocytopenia by Methylprednisolone in Rats

Yao

DuBois

Almon

et al. 2008

Journal of Pharmaceutical Sciences

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Adrenal suppression and lymphocytopenia are commonly monitored pharmacological responses during systemic exposure to exogenously administered corticosteroids. The pharmacodynamics of plasma corticosterone (CS) and blood lymphocytes were investigated in 60 normal rats which received either 50 mg/kg methylprednisolone (MPL) or vehicle intramuscularly. Blood samples were collected between 0.5 and 96 h following treatment. Plasma CS displayed a transient suppression with re-establishment of a normal circadian rhythm 24 h following drug treatment. An indirect response model with suppression of production well captured plasma CS profiles. An early stress-induced rise in CS was also factored into the model. Blood lymphocyte numbers exhibited a sharp decline and then returned to a new circadian rhythm which was half of the original baseline level. An integrated pharmacodynamic (PD) model with inhibition of lymphocyte trafficking from tissue to blood by both MPL and CS and induction of cell apoptosis by MPL reasonably captured this lymphocytopenia. Rats and humans differ in lymphocyte responses with humans showing full recovery of baselines. Modeling provides a valuable tool in quantitative assessment of dual, complex drug responses.

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Body weight gain and diurnal differences of corticosterone changes in response to acute and chronic stress in rats

Cited by 128 publications

References 64 publications

Moods in everyday situations: effects of menstrual cycle, work, and stress hormones

Moods in everyday situations: effects of menstrual cycle, work, and stress hormones

Exposure to Stressors during Juvenility Disrupts Development-Related Alterations in the PSA-NCAM to NCAM Expression Ratio: Potential Relevance for Mood and Anxiety Disorders

Pharmacokinetic/Pharmacodynamic Modeling of Corticosterone Suppression and Lymphocytopenia by Methylprednisolone in Rats

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