Body mass index during childhood and adult body composition in men and women aged 56–70 y

Ylihärsilä, Hilkka; Kajantie, Eero; Osmond, Clive; Forsén, Tom; Barker, D. J. P.; Eriksson, Johan G.

doi:10.1093/ajcn/87.6.1769

Cited by 98 publications

(78 citation statements)

References 32 publications

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“…[16][17][18][19][20][21]33 The association of high weight gain to later child and adult weight status in general populations of children has been noted as early as the first weeks of life, [34][35][36] the first 3 to 6 months, 16,17,37,38 the first year 35,39,40 and the first 2 years 17,41,42 and beyond. 38 There has been no uniform definition of high or excessive weight gain, but methods have included absolute weight gain (gram per months), 16,37 change in weight adjusted standard deviation score 38,42 and change in Z scores. 35,43 Reports have been cross-sectional, 37 retrospective 42,44 and longitudinal.…”

Section: Discussionmentioning

confidence: 99%

Evolution of obesity in a low birth weight cohort

et al. 2011

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Objective: The objective of this study was to determine the evolution of obesity status (OS) in a longitudinal cohort of low birth weight preterm (LBWPT) infants to an age of 8 years, and to determine whether rapid weight gain in the first year of life independently predicts 8-year OS.Study Design: In total, 985 infants (birth weight p2500 g, gestation age p37 weeks) were recruited from the nursery in an eight-site intervention research program and were evaluated at an age of 3, 5, 6.5 and 8 years. Weight and height were measured by standard protocol at each visit and body mass index was calculated. Obesity status is X95% for age and sex. Multiple logistic analyses were performed on 8-year OS with predictor variables including infant race, gender, small for gestational age status, birth weight category, neonatal health index, treatment group and first-year weight gain; maternal education and weight status before conception; and HOME Inventory.Result: Overall, 2.3% were OS at an age of 3 years, 6.1% at an age of 5 years, 7.7% at age 6.5 years and 8.7% at an age 8 years. OS varied by birth weight category at each visit. The infants born p1500 g had the lowest prevalence of OS at each age. In the logistic regression, maternal race (Hispanic) (adjusted odds ratio ¼ 2.8, confidence interval ¼ 1.2 to 6.8), maternal obese status (adjusted odds ratio 3.4, confidence interval ¼ 1.5 to 7.8) and first-year weight gain (adjusted odds ratio ¼ 2.7, confidence interval ¼ 1.9 to 3.9), significantly predicted 8-year OS.Conclusion: OS is common in LBWPT infants during childhood, and prevalence varies by birth weight category. High weight gain in the first year of life is an important predictor of the development of OS in LBWPT children.

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Section: Discussionmentioning

confidence: 99%

Evolution of obesity in a low birth weight cohort

et al. 2011

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“…26 The subjects were born between 1934 and 1944 in the Helsinki University Central Hospital and attended child welfare clinics in the city. In the year 2000, those who were still alive and residing in Finland were sent questionnaires resulting in data from 4515 subjects.…”

Section: Subjects and Methods Participantsmentioning

confidence: 99%

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Männistö

et al. 2012

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: Shorter leukocyte telomere length (LTL) is associated with several chronic diseases, but only a few studies have assessed the association between dietary factors and LTL. Our objective was to study the association between fats, fruits, vegetables and LTL in a cross-sectional study design. We hypothesized that intakes of fruits and vegetables would be positively associated with LTL and that intakes of fats, and especially saturated fatty acids (SFAs), would be negatively associated with LTL. SUBJECTS/METHODS: LTL was measured by quantitative real-time polymerase chain reaction in 1942 men and women aged 57-70 years from the Helsinki Birth Cohort Study. We assessed the whole diet by a validated semiquantitative 128-item food-frequency questionnaire. RESULTS: In general, there were only a few significant results. However, total fat and SFA intake (P ¼ 0.04 and 0.01, respectively) were inversely associated with LTL in men adjusting for age and energy intake. In women, vegetable intake was positively associated with LTL (P ¼ 0.05). Men consuming the most butter and least fruits had significantly shorter telomeres than those consuming the lowest amounts of butter and highest amounts of fruits (P ¼ 0.05). We found no association between LTL and body mass index, waist-hip ratio, smoking, physical activity or educational attainment. CONCLUSIONS: In this cross-sectional study of elderly men and women, there were only a few statistically significant effects of diet, but in general they support the hypothesis that fat and vegetable intakes were associated with LTL.

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“…Pesquisadores avaliaram a relação do peso na infância com o risco de doenças na idade adulta. Ylihärsilä et al verificaram que um rápido aumento do IMC após os 2 anos de vida em humanos está relacionado a um maior acúmulo de massa adiposa na idade adulta 28 .…”

Section: Gc (N = 8) Gl (N = 8) Punclassified

Maternal consumption of flaxseed during lactation affects weight and hemoglobin level of offspring in rats

Cardozo¹,

Soares²,

Chagas³

et al. 2010

J Pediatr (Rio J)

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Objective: To investigate the effects of maternal flaxseed consumption during lactation on the body weight, hematological indicators and visceral fat mass of male offspring in adulthood. Methods:Sixteen female Wistar rats were divided into two groups after giving birth. During lactation the control group (CG) was fed a casein-based diet and the flaxseed group (FG) was fed a casein-based diet containing 25% flaxseed. After weaning, male offspring were fed on commercial chow until adulthood and euthanized at 170 days for blood collection and visceral fat mass assessment. Results:Offspring of rats in the FG had lower body weight (FG = 42.69±3.06 g; CG = 47.31±4.72 g; p = 0.036) at weaning. At 170 days, lower hemoglobin levels were observed in the FG (FG = 12.30±1.28 g/dL; CG = 13.88±0.91 g/dL; p = 0.02). There was no statistically significant difference in visceral fat mass between groups. Conclusions:Maternal consumption of a flaxseed-based diet during lactation resulted in lower body weight at weaning and lower hemoglobin levels in adulthood, when compared with the control group. (Rio J). 2010;86(2):126-130: Flaxseed, rats, programming, lactation, hemoglobin. J Pediatr ResumoObjetivo: Avaliar os efeitos do consumo da semente de linhaça durante a lactação sobre o peso corporal, indicadores hematológicos e massa de gordura visceral dos filhotes de ratas na idade adulta. Métodos:Foram utilizadas 16 ratas Wistar que, após o parto, foram divididas em dois grupos que receberam, durante a lactação, as seguintes dietas: grupo-controle (GC), ração à base de caseína, e grupo linhaça (GL), ração à base de caseína contendo 25% de semente de linhaça. Ao desmame, os filhotes machos passaram a receber ração comercial até a idade adulta, quando foram sacrificados aos 170 dias de vida para coleta de sangue e avaliação da massa de gordura visceral.Resultados: Foi encontrado menor peso corporal da prole do GL (GL = 42,69±3,06 g; GC = 47,31±4,72 g; p = 0,036) ao desmame. Aos 170 dias de idade foram observados menores valores na hemoglobina do GL (GL = 12,30±1,28 g/dL; GC = 13,88±0,91 g/dL; p = 0,02). Não foram verificadas diferenças estatísticas na massa de gordura visceral entre os grupos. Conclusões:O consumo materno da ração à base de semente de linhaça durante a lactação promoveu menor peso ao desmame e níveis menores de hemoglobina na idade adulta quando comparados ao GC. IntroduçãoA prevenção de doenças deve ocorrer ao longo da vida, iniciando com a dieta materna durante a gestação, a lactação, até a idade adulta 1 . Silveira et al. relataram que estudos epidemiológicos em diferentes partes do mundo relacionam a influência de determinados fatores ambientais no início da vida com alterações na expressão da carga genética do indivíduo 2 . Esse fato é denominado "programação", processo pelo qual determinado fator atua no início da vida, num período crítico ou sensível, podendo gerar efeitos na saúde na idade adulta 3 . Diversos estudos têm indicado que a nutrição

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Body mass index during childhood and adult body composition in men and women aged 56–70 y

Abstract: Rapid gain in BMI before the age of 2 y increased adult lean body mass without excess fat accumulation, whereas rapid gain in BMI in later childhood, despite the concurrent rise in lean mass, resulted in relatively larger increases in fat mass.

Cited by 98 publications

References 32 publications

Evolution of obesity in a low birth weight cohort

Evolution of obesity in a low birth weight cohort

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Maternal consumption of flaxseed during lactation affects weight and hemoglobin level of offspring in rats

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