Body Mass Index and High-Density Lipoproteins in Cherokee Indian Children and Adolescents

Blackett, Piers R.; Blevins, Kathleen S.; Stoddart, Martha L.; Wang, Wenyu; Quintana, Elaine; Alaupovic, Petar; Lee, Elisa T.

doi:10.1203/01.pdr.0000176947.98014.44

Cited by 12 publications

(13 citation statements)

References 64 publications

(40 reference statements)

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“…Whereas a Mediterranean study performed in Spain demonstrated that the BMI values do not have any impact on the lipid profile, and that, on the contrary, waist circumference and age is effective [26]. A study made on the U.S. Cherokee Indians demonstrated that obesity in adolescents emerges along with a decrease of HDL-C [27]. We have found a relation between HOMA-IR and the BMI and waist circumference.…”

Section: Discussionmentioning

confidence: 45%

Body Mass Index and Waist Circumference Affect Lipid Parameters Negatively in Turkish Women

Özkaya¹,

Bavunoğlu²,

Tunçkale³

2014

AJPHR

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Study Design:Obesity prevalence is incresing in Turkish population whose lipoprotein profile is characterised by low levels of HDL cholesterol. Our study aims to determine how obesity changes lipid profiles in Turkish women. Materials and Methods: We evaluated 2501 overweight and obese adult women. After systemic physical examination and some antropometric studies, blood samples have been analysed for lipid parameters.

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Section: Discussionmentioning

confidence: 45%

Body Mass Index and Waist Circumference Affect Lipid Parameters Negatively in Turkish Women

Özkaya¹,

Bavunoğlu²,

Tunçkale³

2014

AJPHR

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“…Apolipoprotein B (apoB) represents the total number of apoB-containing lipoproteins [7] and is considered to be superior to LDL-C and non-HDL-C in predicting cardiovascular disease [8], whereas apolipoprotein A-I (apoA-I) has a known inverse association and low levels are associated with increased body mass index (BMI) [9]. Furthermore, the ratio of apoB to apoA-I (B : A-I ratio), representing the combination of two atherogenic processes, is an even stronger predictor [10].…”

Section: Introductionmentioning

confidence: 99%

Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee

et al. 2017

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Since young adult Cherokee are at increased risk for both diabetes and cardiovascular disease, we assessed association of apolipoproteins (A-I, B, and C-III in non-HDL and HDL) with obesity and related risk factors. Obese participants (BMI ≥ 30) aged 20–40 years (n = 476) were studied. Metabolically healthy obese (MHO) individuals were defined as not having any of four components of the ATP-III metabolic syndrome after exclusion of waist circumference, and obese participants not being MHO were defined as metabolically abnormal obese (MAO). Associations were evaluated by correlation and regression modeling. Obesity measures, blood pressure, insulin resistance, lipids, and apolipoproteins were significantly different between groups except for total cholesterol, LDL-C, and HDL-apoC-III. Apolipoproteins were not correlated with obesity measures with the exception of apoA-I with waist and the waist : height ratio. In a logistic regression model apoA-I and the apoB : apoA-I ratio were significantly selected for identifying those being MHO, and the result (C-statistic = 0.902) indicated that apoA-I and the apoB : apoA-I ratio can be used to identify a subgroup of obese individuals with a significantly less atherogenic lipid and apolipoprotein profile, particularly in obese Cherokee men in whom MHO is more likely.

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“…HDL-C levels in Cherokee Indian children aged 5–19 years were shown to decrease across increasing BMI z-quartiles in all age groups [15]. In another study, overweight males and females aged 9–17 years had lower HDL-C and higher LDL-C and TG levels than non-overweight children (overweight defined as BMI ≥85th percentile for specific age and sex groups using BMI distributions from the combined National Health and Nutrition Examination Survey [NHANES] I and II dataset) [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…However, most studies exploring the association of adiposity with blood lipids and lipoproteins have been cross-sectional and thus unable to examine the associations of concurrent changes in body composition and blood lipids. Furthermore, these studies have not accounted for important factors that may influence these changes, such as stage of maturation, energy intake or physical activity behaviors [15–18]. …”

mentioning

confidence: 99%

Associations of BMI and its fat-free and fat components with blood lipids in children: Project HeartBeat!

Dai¹,

Eissa²,

Steffen³

et al. 2011

Clinical Lipidology

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Aim This study aimed to distinguish between the roles of the two components of BMI, the fat mass (FM) index and the fat-free mass (FFM) index, in BMI’s association with blood lipids in children and adolescents. Methods A total of 678 children (49.1% female, 79.9% non-black), initially aged 8, 11 and 14 years, were followed at 4-month intervals for up to 4 years (1991–1995). Total cholesterol (TC), LDL-C, HDL-C and triglycerides were determined in fasting blood samples. FFM index and FM index were calculated as FFM (kg)/height (m)2 and FM (kg)/height (m)2, respectively. Using a multilevel linear model, repeated measurements of blood lipids were regressed on concurrent measures of BMI or its components, adjusting for age, sex and race and, in a subsample, also for physical activity, energy intake and sexual maturity. Results Estimated regression coefficients for the relations of TC with BMI, FFM index and FM index were 1.539, −0.606 (p > 0.05) and 3.649, respectively. When FFM index and FM index were entered into the TC model simultaneously, regression coefficients were −0.855 and 3.743, respectively. An increase in BMI was related to an increase in TC; however, an equivalent increase in FM index was related to a greater increase in TC and, when FFM index was tested alone or with FM index, an increase in FFM index was related to a decrease in TC. Similar results were observed for LDL-C. FFM index and FM index were both inversely related to HDL-C and directly to triglycerides. Compared with FFM index, the equivalent increase in FM index showed a greater decrease in HDL-C. Conclusion Greater BMI was related to adverse levels of blood lipids in children and adolescents, which was mainly attributable to BMI’s fat component. It is important to identify weight management strategies to halt the childhood obesity epidemic and subsequently prevent heart disease in adulthood.

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Body Mass Index and High-Density Lipoproteins in Cherokee Indian Children and Adolescents

Cited by 12 publications

References 64 publications

Body Mass Index and Waist Circumference Affect Lipid Parameters Negatively in Turkish Women

Body Mass Index and Waist Circumference Affect Lipid Parameters Negatively in Turkish Women

Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee

Associations of BMI and its fat-free and fat components with blood lipids in children: Project HeartBeat!

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