Body fat percentage is a better marker than body mass index for determining inflammation status in polycystic ovary syndrome

Hestiantoro, Andon; Hasani, Rachmat Dediat Kapnosa; Shadrina, Amalia; Situmorang, Herbert; Ilma, Nurul; Natadisastra, Muharam; Sumapraja, Kanadi; Wiweko, Budi

doi:10.29252/ijrm.16.10.623

Cited by 16 publications

(16 citation statements)

References 18 publications

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“…Studies investigating body composition by BIA reported that in PCOS women higher metabolic dysfunction was associated with higher fat mass (FM) and fat-to-lean mass ratio as compared to controls [22]. In addition, body fat percentage was positively associated with levels of inflammatory biomarkers [23].…”

Section: Introductionmentioning

confidence: 99%

Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS)

et al. 2019

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Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Obesity, low-grade chronic inflammatory status, and insulin-resistance (IR) often coexist in PCOS. The Mediterranean diet (MD) is an anti-inflammatory dietary pattern, which is rich in complex carbohydrates and fiber, and high in monounsaturated fat. There is a close association among obesity, low-grade chronic inflammation, IR, and hormonal derangements in PCOS. The main aim of the present study was to evaluate the adherence to MD, the dietary intake, and the body composition and their association with PCOS clinical severity in a cohort of treatment-naïve women with PCOS when compared with a control group of healthy women matched for age and body mass index (BMI). In this case-controlled, cross-sectional study, we enrolled 112 patients with PCOS and 112 controls. PREvención con DIetaMEDiterránea (PREDIMED) and seven-day food records were used to evaluate the degree of adherence to the MD and dietary pattern, respectively. Body composition was evaluated by bioelectrical impedance analysis (BIA) phase-sensitive system. Testosterone levels and Ferriman-Gallwey score assessed the clinical severity of PCOS. C-reactive protein (CRP) levels were determined with a nephelometric assay with CardioPhase high sensitivity. PCOS women showed higher testosterone levels, Ferriman-Gallwey score, fasting insulin and glucose levels, and Homeostatic Model Assessment (HoMA)-IR when compared with the control group (p < 0.001). In addition, we found that the PCOS women consumed less extra-virgin olive oil, legumes, fish/seafood, and nuts compared with control group. Despite no differences in energy intake between the two groups, the PCOS women consumed a lower quantity of complex carbohydrate, fiber, monounsaturated fatty acids (MUFA), and n-3 polyunsaturated fatty acid (PUFA), and higher quantity of simple carbohydrate, total fat, saturated fatty acid (SFA), PUFA and n-6 PUFA than the control group. The PCOS women have an adverse body composition when compared with controls, with the lowest values of phase angle (PhA) and fat-free mass (p < 0.001). Additionally, after adjusting for BMI and total energy intake, testosterone levels showed significant negative correlations with PREDIMED score (p < 0.001) and consumption of protein (p = 0.005), complex carbohydrate (p < 0.001), fiber (p < 0.001), MUFA (p < 0.001), n-3 PUFA (p = 0.001), and positive associations with CRP levels, simple carbohydrate, SFA, n-6 PUFA (p < 0.001, respectively), and PUFA (p = 0.002). The cut-off for PREDIMED score ≤ 6 (p < 0.001, area under the curve (AUC) 0.848, standard error 0.036, 95% confidence interval (CI) 0.768 to 0.909) could serve as a threshold for significantly increased risk of high value of testosterone levels. In conclusion, a novel direct association between the adherence to MD and the clinical severity of the disease was reported in women with PCOS. This association could support a t...

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Section: Introductionmentioning

confidence: 99%

Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS)

et al. 2019

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“…Polycystic ovary syndrome (PCOS), an endocrine disorder affects approximately 14-19% % of women in reproductive age [1]. PCOS has been associated with low-grade inflammation based on increased levels of several inflammatory mediators.…”

Section: Introductionmentioning

confidence: 99%

A study of inflammatory markers in women with polycystic ovary syndrome

Singh¹,

Hooja²,

Sharma³

et al. 2022

Int. J. Front. Sci. Technol. Res.

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Polycystic ovary syndrome (PCOS), an endocrine disorder has been associated with low-grade inflammation based on increased levels of several inflammatory mediators. Aim of the study was to assess the inflammatory markers in women with PCOS and their correlation with each other. Various inflammatory markers, neutrophil/lymphocyte ratio, hsC-reactive protein and CRP albumin ratio were found to be increased in women with PCOS in the study. Early detection of raised levels of inflammatory markers may help early diagnosis of PCOS and prevent development of metabolic syndrome.

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“…One of the theories says that ovarian polycystic syndrome is a condition of chronic inflammation in low degree. 5 There are several markers that can be used to measure inflammation, including CRP, Neutrophil to Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), and monocyte/HDL ratio. Complete blood count is an inexpensive, routine, and feasible test that may provide information regarding the red blood cells, white blood cells, and platelets.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory markers in lean Polycystic Ovary Syndrome subjects are not associated with the spectrum of dyslipidemia

Atnil

Hestiantoro

Riayati

et al. 2022

MOG

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HIGHLIGHTS 1. Polycystic ovarian syndrome (PCOS) might be a condition of chronic low degree inflammation and dyslipidemia.2. Association between inflammation markers and dyslipidemia in PCOS patients was investigated.3. Dyslipidemia and chronic low degree inflammation were present in lean PCOS patients, but inflammation markers related insignificantly with dyslipidemia. ABSTRACT Objectives: This study aimed to address the detailed lipid profile in lean woman with PCOS and investigate the relationship between chronic low grade inflammation (using NLR, PLR, and monocyte/HDL ratio) and dyslipidemia (defined as total cholesterol level > 190 mg/dL). Materials and Methods: This study was a cross-sectional study conducted from June – December 2020 at the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, involving 45 women aged 18 – 35 years old, diagnosed as having PCOS with normal BMI (18.5 – 22.9 kg/m2). To compare quantitative variables, data analysis was carried out using the t-test or Mann-Whitney U test as appropriate; whereas, to compare categorical variables, the Chi-square test was used. Results: We found that although the median BMI was within normal limits at 21.48 kg/m2, the mean values of the lipid profiles were found to be either abnormal or borderline, indicating the high possibility of dyslipidemia. No statistically association between NLR, PLR and MHR with dyslipidemia. Conclusion: Dyslipidemia and chronic low-grade inflammation were found in lean PCOS subjects, but there was no significant association between inflammation markers (NLR, PLR and MHR) and dyslipidemia. Further studies should investigate other factors that cause the inflammation.

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Body fat percentage is a better marker than body mass index for determining inflammation status in polycystic ovary syndrome

Cited by 16 publications

References 18 publications

Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS)

Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS)

A study of inflammatory markers in women with polycystic ovary syndrome

Inflammatory markers in lean Polycystic Ovary Syndrome subjects are not associated with the spectrum of dyslipidemia

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