Body fat distribution and its association with metabolic and hormonal risk factors in women with angiographically assessed coronary artery disease. Evidence for the presence of a metabolic syndrome

Hauner, Hans; Bognar, Eszter; Blum, Arnon

doi:10.1016/0021-9150(94)90051-5

Cited by 33 publications

(17 citation statements)

References 32 publications

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“…However, it is unlikely that these measurement problems were differentially large enough to explain the discrepancy between this study and others employing similar measuring methods to determine WHR. 5,9,10,28,32,33 The absence of a positive relationship to WHR in the present study may also be attributed to the racial difference in cultural and genetic backgrounds, as the Seven Countries Study showed a differential pro®le of risk factors for coronary heart disease in Japan. 21 However, two relevant studies on the Japanese 11 and Japanese Americans 42 afforded positive ®ndings.…”

Section: Discussionmentioning

confidence: 66%

Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women

et al. 2001

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OBJECTIVE:To investigate the relation of the obesity and body-fat distribution with angiographically de®ned coronary atherosclerosis. DESIGN: Cross-sectional study in a clinical setting. SUBJECTS: Three hundred and twenty men (median age, 59 y) and 212 women (median age, 67 y) who underwent coronary angiography for suspected or known coronary heart disease at 5 cardiology departments between September 1996 and August 1997. Patients with disease duration b1 y were excluded. MEASUREMENTS: The body mass index (BMI) and the waist to hip circumference ratio (WHR) were used as main exposure variables, and either the presence of signi®cant coronary stenosis or the Gensini's score ( 10 vs`10) as an outcome variable, in a sex-speci®c multiple logistic regression analysis controlling for age, hospital, and other coronary risk factors. RESULTS: Among male patients, BMI was progressively higher with an increasing number of vessels involved (P trend 0.05); the adjusted odds ratios for the presence of signi®cant stenosis across quartiles of BMI were 1.0 (reference), 1.1, 1.9 and 2.5 (P trend 0.02), and the positive association was more pronounced for younger patients. Among females, however, such associations were not evident. Employing the Gensini's score as an outcome gave similar results. WHR was not signi®cantly associated with either outcome regardless of sex. CONCLUSION: These results suggested that BMI was predictive of coronary stenosis among male patients, but not among female patients. Unlike most previous studies, this study failed to detect a positive association with WHR.

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Section: Discussionmentioning

confidence: 66%

Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women

et al. 2001

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“…FAI was positively related to waist circumference and was significantly higher in menopausal women compared with the premenopausal group (88). In an earlier case-control study of Hauner et al (89) in women undergoing coronary angiography, testosterone was positively associated with the waist:hip ratio, an index of central adiposity, as well as with insulin levels. A positive association of hyperinsulinemia with total testosterone and FAI was also demonstrated in a study on 104 peri-and postmenopausal women, and this was independent of age, BMI, and time since menopause (90).…”

Section: Obesity-insulin Resistance-metabolic Syndromementioning

confidence: 86%

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Παππά

Alevizaki

2012

European Journal of Endocrinology

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Objective: Cardio-and cerebro-vascular diseases are two leading causes of death and long-term disability in postmenopausal women. The acute fall of estrogen in menopause is associated with increased cardiovascular risk. The relative contribution of androgen to this risk is also being recognized. The use of more sensitive assays for estradiol measurement and the study of receptor and carrier protein gene polymorphisms have provided some new information on the clinical relevance of endogenous sex steroids. We provide an update on the role of endogenous sex steroids on cardio-and cerebro-vascular disease in the postmenopausal period. Design and methods: We performed a PubMed search using the terms 'endogenous estrogen', 'androgen', 'cardiovascular disease', 'cerebro-vascular disease', 'stroke', 'carotid artery disease', and 'subclinical atherosclerosis'. Results: The majority of studies show a beneficial effect of endogenous estrogen on the vasculature; however, there are a few studies reporting the contrary. A significant body of literature has reported associations of endogenous estrogen and androgen with early markers of atherosclerosis and metabolic parameters. Data on the relevance of endogenous sex steroids in heart disease and stroke are inconclusive. Conclusions: Most studies support a beneficial role of endogenous estrogens and, probably, an adverse effect of androgens in the vasculature in postmenopausal women. However, the described associations may not always be considered as causal. It is possible that circulating estrogen might represent a marker of general health status or alternatively reflect the sum of endogenous androgens aromatized in the periphery. Elucidating the role of sex steroids in cardio-and cerebro-vascular disease remains an interesting field of future research.

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“…Previous studies show that hyperinsulinemia leads to increased renal sodium reabsorption, and this increase is strongly associated with an increase in renal reabsorption of uric acid. Insulin resistance could therefore represent a connection between elevation of arterial pressure and hyperuricemia as well as the relation of this with other metabolic alterations in the state of insulin resistance, such as diabetes, obesity, and dyslipidemia [16][17][18] . In the present study, the presence of associated risk factors for cardiovascular diseases occurred homogeneously among the three groups.…”

Section: Resultsmentioning

confidence: 99%

Diet and medication in the treatment of hyperuricemia in hypertensive patients

Peixoto¹,

Monego²,

Jardim³

et al. 2001

Arq. Bras. Cardiol.

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Body fat distribution and its association with metabolic and hormonal risk factors in women with angiographically assessed coronary artery disease. Evidence for the presence of a metabolic syndrome

Cited by 33 publications

References 32 publications

Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women

Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Diet and medication in the treatment of hyperuricemia in hypertensive patients

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