Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats

Bazile, Didier; Ropert, Catherine; Huve, P.; Verrecchia, T.; Mariard, M.; Frydman, Armand; Veillard, M.; Spenlehauer, G.

doi:10.1016/0142-9612(92)90142-b

Cited by 188 publications

(81 citation statements)

References 27 publications

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“…An increase in thickness was found for an increased number of PEO units in the co-polymer chain. Poloxamines 901, 904, and 908 contain 4,15 and 119 PEO units, respectively, per PEO chain, whereas they all share a common anchoring polypropylene oxide (PPO) chain of 68 PPO units. The related series of poloxamers each share a common anchoring chain of 69 PPO units with 5, 11, 20 and 98 PEO units per PEO chain for poloxamers 401,402,403 and 407, respectively (Table I).…”

Section: Resultsmentioning

confidence: 99%

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Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block co‐polymers

1997

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Studies were performed to develop a sub-lOO nm biodegradable colloidal system for the efficient delivery of drugs and diagnostic agents to the lymphatic system. Nanospheres of poly(lactide-co-glycolide) were prepared by interfacial polymer deposition. The nanospheres were coated with block co-polymers in order to modify their surface characteristics. Radiolabelling of the nanospheres for in vivo tracing was achieved by the incorporation of the lipophilic complex 111 In-oxine during nanosphere preparation. In vitro stability of the radiolabelled nanospheres was determined in rat serum at 37°C. The lymphatic distribution of the nanospheres was determined after subcutaneous administration to the rat. Lymphatic uptake of all coated systems was enhanced compared to the uncoated nanospheres, and a maximal uptake of 17% of the administered dose in the regional lymph nodes was achieved. These observations suggest that the nanospheres are suitable for diagnostic and therapeutic applications in clinical and experimental medicine.

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Section: Resultsmentioning

confidence: 99%

“…Other workers [15] have radio labelled poly(lactic acid) using 14C, in which the radiolabelled PLA was synthesised from D,Llactic acid [carbonyl 14C]. Nanospheres were then prepared by a precipitation method.…”

Section: Resultsmentioning

confidence: 99%

Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block co‐polymers

1997

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“…52,53 No mortality was reported with albumin-coated nanoparticles in mice with up to a 2000 mg/kg dose. 44 However, PLA 60000 nanoparticles stabilized with sodium cholate were much more toxic with two of five deaths at a 220 mg/kg dose and five of five at a 440 mg/kg dose associated with marked clinical signs (dyspnea, reduced locomotor activity), alteration of hematological and biochemical parameters and lung hemorrhage. 54 This toxicity was attributed to a disseminated intravascular coagulation and associated events related to the physical surface properties of the nanoparticles rather than to the chemical toxicity of cholate or PLA.…”

Section: General Considerationsmentioning

confidence: 99%

“…After intravenous administration of 14 C-PLA 18000 radiolabeled nanoparticles to rats, 90% of the recovered 14 C was eliminated within 25 days, among which 80% was as CO 2 . 44 Degradation rate depends on four basic parameters: hydrolysis rate constant (depending on the molecular weight, the lactic/glycolic ratio, and the morphology), amount of water absorbed, diffusion coefficient of the polymer fragments through the polymer matrix, and solubility of the degradation products in the surrounding aqueous medium. 40,41 All of these parameters are influenced by temperature, additives (including drug molecules), pH, ionic strength, buffering capacity, size and processing history, steric hindrance etc.…”

Section: General Considerationsmentioning

confidence: 99%

Drug transport to brain with targeted nanoparticles

2005

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Summary: Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50 -300 nm generally). They cannot freely diffuse through the bloodbrain barrier (BBB) and require receptor-mediated transport through brain capillary endothelium to deliver their content into the brain parenchyma. Polysorbate 80-coated polybutylcyanoacrylate nanoparticles can deliver drugs to the brain by a still debated mechanism. Despite interesting results these nanoparticles have limitations, discussed in this review, that may preclude, or at least limit, their potential clinical applications. Long-circulating nanoparticles made of methoxypoly(ethylene glycol)-polylactide or poly(lactide-co-glycolide) (mPEG-PLA/ PLGA) have a good safety profiles and provide drug-sustained release. The availability of functionalized PEG-PLA permits to prepare target-specific nanoparticles by conjugation of cell surface ligand. Using peptidomimetic antibodies to BBB transcytosis receptor, brain-targeted pegylated immunonanoparticles can now be synthesized that should make possible the delivery of entrapped actives into the brain parenchyma without inducing BBB permeability alteration. This review presents their general properties (structure, loading capacity, pharmacokinetics) and currently available methods for immunonanoparticle preparation.

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“…Nanoparticles are made from materials such as cadmium selenide [4,5], gold [6], silver [7], perylene [8], polystyrene [9], carbon [10,11], iron oxide [12], silica [13], titanium dioxide [14]. Some types of nanoparticles are organic-based such as latex [15], polylactic acid [16], polyglycolic acid [17] and polyalkylcyanoacrylate [18] while others are based on carbon, sulfates, nitrates [19,20], aluminum, silicon, or titanium [21].…”

Section: Introductionmentioning

confidence: 99%

In vitro tagging of embryos with nanoparticles

Fynewever

Agcaoili

Jacobson

et al. 2006

J Assist Reprod Genet

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Purpose: To develop an in vitro method for tagging embryos and to compare the development of the embryos after nanoparticles injection versus externally-applied nanoparticles derived from either polystyrene or polyacrylonitrile.Methods: Each mouse 1-cell embryo (the selected testmodel) was either: (a) injected by intracytoplasmic injection or (b) co-incubated with different nanoparticles at 37 • C, 5% CO 2 in air. The embryos were assessed after 2 and 6 days of culture.Results: Embryo development was similar for externallyapplied polystyrene nanoparticles and control (97.6 ± 2.7 versus 100.0 ± 0%) but different for polyacrylonitrile nanoparticles (90.0 ± 2.8 %) on day 2. However, the results were similar on Day 6. Injected embryos were linked to lower percent development on Day 2. Few injected embryos reached blastocyst stage on Day 6 after a brief UVfluorescence exposure.Conclusions: Tagging embryos by external polystyrenebased nanoparticles was the better method when compared with injected nanoparticles. Larger nanoparticles in micro-

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Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats

Cited by 188 publications

References 27 publications

Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block co‐polymers

Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block co‐polymers

Drug transport to brain with targeted nanoparticles

In vitro tagging of embryos with nanoparticles

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