Body composition among patients undergoing surgery for colorectal cancer

Tojek, Krzysztof; Banaszkiewicz, Zbigniew; Budzyński, Jacek

doi:10.5114/pg.2021.104736

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…www.journals.viamedica.pl/medical_research_journal Concerning deterioration in patients' functional status during the 3-month follow-up, other studies corroborate the obtained results, showing that people with malnutrition and/ or sarcopenia have a higher risk of in-hospital death and complications [11][12][13][15][16] and need a longer hospital stay [26,27]. Short-term outcomes after CRC surgery were discussed in earlier research [7]. According to the current definition of sarcopenia [28][29][30], this clinical condition should be diagnosed based on the confirmation, in order, of the following criteria: impairment in patient's performance (loss of skeletal muscle function), low skeletal muscle strength, and loss of muscle mass.…”

Section: Discussionsupporting

confidence: 67%

“…For all the patients with CRC, the following biochemical determinations were performed in the hospital's diagnostic laboratory using standard methods: blood morphology with a detailed determination of white blood cell distribution (total lymphocyte count [TLC] and neutrophils), glucose, albumin, C-reactive protein (CRP), and carcinoembryonic antigen (CEA). The Preoperative Onodera's Prognostic Nutritional Index (OPNI) was also calculated according to the following formula: [10 × blood albumin concentration (g/l)] + [0.005 × TLC (G/l)] [7].…”

Section: Biochemical Determinationsmentioning

confidence: 99%

“…However, the association is complex. On the one hand, overweight and obesity are linked to longer survival of CRC patients after treatment, which is mostly interpreted as the presence of the "obesity paradox" [6][7][8][9]. On the other, there is strong evidence that both malnutrition [10][11][12][13][14] and excess body fat, visceral adiposity, and sarcopenia (reduced skeletal muscle mass, strength and functional performance), especially when it coexists with obesity (sarcopenic obesity), contribute to worse short-, medium-and long-term outcomes of CRC treatment [1, 2, 6-8, 11-13, 15, 16].…”

Section: Introductionmentioning

confidence: 99%

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Nutritional and functional status as indices of short- and long-term prognosis in patients undergoing surgery due to colorectal cancer

Szukay

Tojek

Kowalczyk

et al. 2022

Medical Research Journal

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Introduction: Nutritional status and body composition parameters would seem to be reasonable prognostic factors in patients with colorectal cancer (CRC). The study aimed to investigate the relationships between numerous parameters of nutritional status and prognosis in patients undergoing surgery due to CRC.Material and methods: Clinical nutritional assessment and biochemical determinations were performed on 110 patients who underwent elective surgery due to primary CRC. Body composition was also analyzed using bioelectrical impedance (BIA) and computed tomography (CT) scans at the third lumbar (L3) vertebra using OsiriX software.Results: Patients who failed to attend a visit 3 months after surgery (n = 15; 13.6%) were more likely to be sarcopenic, with lower baseline functional status, handgrip strength, skeletal muscle (SM) parameters in BIA and a smaller SM area in CT. Compared to those who died during, on average, 3.6 years of follow-up (n = 33; 30%), patients who survived had, at baseline, a significantly higher Mini-Nutritional Assessment (MNA) score, lower waist-to-height ratio (WHtR), and higher scores on functional status scales. In a Cox's proportional-hazards model, in addition to an advanced WHO CRC stage, scores for MNA (HR; 95% CI: 0.85; 0.74-0.98; p = 0.021), Patient-Generated Subjective Global Assessment (PG-SGA), instrumental activities of daily living (IADL), and WHtR (3.68;; p = 0.049) were independent risk factors for death.Conclusions: Patients' functional status 3 months after surgery due to CRC was related to baseline SM strength, mass, and functional performance, whereas 3.5-year mortality was associated with lower MNA and IADL scores and higher WHtR and PG-SGA scores.

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Section: Discussionsupporting

confidence: 67%

Section: Biochemical Determinationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nutritional and functional status as indices of short- and long-term prognosis in patients undergoing surgery due to colorectal cancer

Szukay

Tojek

Kowalczyk

et al. 2022

Medical Research Journal

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“…There are two methods most commonly used for determining skeletal muscle mass index (SMI): one is SMM [SMM (%) = total skeletal muscle mass (kg)/ body weight mass (kg) × 100%] [21] [22]; the other is SMH (SMH (kg/m 2 ) = total skeletal muscle mass (kg)/height (m) 2 ] [23] [24]. Both procedures are called skeletal muscle mass index (SMI).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Two Algorithms of Skeletal Muscle Mass Index: An Observational Study in a Large Cohort of Chinese Adults

Ying¹,

Huang²,

Dong³

et al. 2022

Health

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Objective: To compare the two skeletal muscle mass index (SMI) algorithms. One is SMM [SMM(%) = total skeletal muscle mass (kg)/body weight mass (kg) × 100%]; and the other is SMH [SMH (kg/m 2 ) = total skeletal muscle mass (kg)/height (m) 2 ]. Methods: Body composition, body mass index (BMI) and body fat percentage (BFP) were estimated using a bioelectrical impedance analyzer. SMI was calculated by the two algorithms described above, and measurement parameters were stratified by age, BMI and levels of physical activity. Results: Levels of BMI, BFP, SMM and SMH differed significantly between the sexes. BMI and BFP were positively associated with age, while SMM was negatively associated with age (β = −0.2294, P < 0.001). Furthermore, SMM was determined to have a negative association with BMI (β = −0.5340, P < 0.001), while a positive association between SMH and BMI (β = 0.7930, P < 0.001) was observed. Both SMM (β = −0.9849, P < 0.001) and SMH (β = −0.0642, P < 0.001) were negatively associated with BFP. In both men and women, SMM maintained the analogous correlation with other indicators. In the general population, SMM showed a gradual downward trend from low body weight to grade III obesity (F = 9528.32, P < 0.001), but SMH (F = 34395.46, P < 0.001) and BFP (F = 9706.20, P < 0.001) had a reciprocal association. BMI, BFP and SMM differences were observed based on levels of physical activity (P < 0.001). However, there was no significant difference in SMH based on exercise (P > 0.05). Conclusions: SMM may be a more ideal and accurate clinical algorithm for SMI because it is more tightly associated with other body composition indices, as compared with SMH.

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“…On the other hand, the decline of IGF-1 levels with ageing has also been explained by reduced physical activity in the elderly [16], decreased muscle volume, increased body fat [17], and poor nutritional status [18]. Indeed, studies in sarcopenia and IGF-1 and GH/IGF-1 axis have shown reduced levels of IGF-1 [19] and disturbed GH/IGF-1 axis in the elderly [20,21], patients with colorectal cancer [22][23][24], patients with pancreatic cancer [25], and patients with gastrointestinal cancer [26]. For reviews about the underling mechanism, see also [27,28].…”

Section: Introductionmentioning

confidence: 99%

The Role of Insulin-Like Growth Factor 1 in Delirium: A Systematic Review and Meta-Analysis

Adamis

Eikelenboom

2022

Dement Geriatr Cogn Disord

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Background: The relationship between delirium and low levels of insulin-like growth factor 1 (IGF-1) is contradictory and uncertain. We hypothesised that low levels of IGF-1 are a predisposing factor for delirium in medical and abdominal surgical cohorts, in contrast to other surgical cohorts. Aims: Systematic review and meta-analysis investigating the association between peripheral levels of IGF-1 and delirium in medical and surgical patients to explore if there are distinct patterns of associations by using subgroup meta-analysis. Methods: PubMed, Scopus, CINAHL, Cochrane, and Embase databases were searched. Inclusion criteria were prospective studies in medical and surgical populations and available data. The following were collected: the setting (surgical/medical), the type (orthopaedic surgery, abdominal, cardiovascular, or medical), the number of participants, mean age, the number of delirious patients, scale/criteria for delirium, IGF-1 levels, and MMSE. Results: Thirteen studies were included and analysed. Low levels of IGF-1 are significantly associated with delirium in abdominal surgical samples and medical samples but not in the other surgical samples. Age, cognition, and the setting (medical vs. surgical) do not have any significant effect on the differences in IGF-1 levels between those with and without delirium. Discussion: Delirium in acute medical and abdominal surgery is triggered by low IGF-1 which may reflect chronic conditions like frailty/cachexia/sarcopenia, while in other surgeries perhaps from an inflammatory process. Conclusions: Low peripheral levels of IGF-1 are a predisposing factor for delirium only in acute medical and abdominal surgery. More studies are needed to confirm and to explore further this finding.

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Body composition among patients undergoing surgery for colorectal cancer

Cited by 6 publications

References 25 publications

Nutritional and functional status as indices of short- and long-term prognosis in patients undergoing surgery due to colorectal cancer

Nutritional and functional status as indices of short- and long-term prognosis in patients undergoing surgery due to colorectal cancer

Comparison of the Two Algorithms of Skeletal Muscle Mass Index: An Observational Study in a Large Cohort of Chinese Adults

The Role of Insulin-Like Growth Factor 1 in Delirium: A Systematic Review and Meta-Analysis

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