BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy

Guan, Qun; Fu, Dandan; Li, Yanan; Kong, Xiangmei; Wei, Zhiyuan; Li, Wenyan; Zhang, Shaojun; Dong, Yu‐Bin

doi:10.1016/j.isci.2019.03.028

Cited by 140 publications

(137 citation statements)

References 146 publications

(147 reference statements)

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“…The PDT effect of traditional PSs (such as porphyrin BODIPY) is usually limited by low cell uptake owing to their poor aqueous solubility. As reported in previous studies, modification or loading of PSs onto nanocarriers can overcome these deficiencies and thus improve antitumor therapy.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Guan

Zhou

et al. 2020

Chemistry A European J

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151

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As newly emerged crystalline porous materials, covalent organic frameworks (COFs) possess fascinating structures and some specific features such as modularity,c rystallinity,p orosity,s tability, versatility,a nd biocompatibility.B esides adsorption/separation, sensing, catalysis, and energy applications, COFs have recently shown ap romise in biomedical applications. This contribution provides an overview of the recent developments of COF-based medicines in cancer therapeutics, including drug delivery,p hotodynamic therapy( PDT), photothermal therapy (PTT), and combined therapy. Furthermore, the major challengesa nd developing trends in this field are also discussed. These recent developments are summarized and discussed to help encourage further contributions in this emerging and promisingf ield.[a] Q.

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Section: Photodynamic Therapymentioning

confidence: 99%

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Guan

Zhou

et al. 2020

Chemistry A European J

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151

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“…Dichtel's and Bein's groups employed monomer‐truncation strategy to create defects for functionalization of COFs. Meanwhile, Yaghi's, Lotsch's, Loh's, and Dong's groups constructed defective COFs via precise controlling the reaction solvent and conditions. As a whole, introducing defects into COFs maybe a good method for enlarging applications and tailoring structures of COFs.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Yaghi's and Lotsch's groups obtained COFs with free amine groups, but have not been utilized for further postfunctionalization. Dong's group prepared NCOFs with free terminal aldehyde groups as anchoring sites for postfunctionalization . However, although several examples have been reported about COFs containing free amine or aldehyde groups, the researches on these two anchoring sites for further functionalization are limited.…”

Section: Introductionmentioning

confidence: 99%

Defective 2D Covalent Organic Frameworks for Postfunctionalization

Liu

et al. 2020

Adv Funct Materials

125

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Defects are deliberately introduced into covalent organic frameworks (COFs) via a three‐component condensation strategy. The defective COFs (dCOF‐NH2‐Xs, X = 20, 40, and 60) possess favorable crystallinity and porosity, as well as have active amine functional groups as anchoring sites for further postfunctionalization. By introducing imidazolium functional groups onto the pore walls of COFs via the Schiff‐base reaction, dCOF‐ImBr‐Xs‐ and dCOF‐ImTFSI‐Xs‐based materials are employed as all‐solid‐state electrolytes for lithium‐ion conduction with a wide range of working temperatures (from 303 to 423 K), and the ion conductivity of dCOF‐ImTFSI‐60‐based electrolyte reaches 7.05 × 10−3 S cm−1 at 423 K. As far as it is known, it is the highest value for all polymeric crystalline porous material based all‐solid‐state electrolytes. Furthermore, Li/dCOF‐ImTFSI‐60@Li/LiFePO4 all‐solid Li‐ion battery displays satisfactory battery performance under 353 K. This work not only provides a new methodology to construct COFs with precisely controlled defects for postfunctionalization, but also makes them promising candidate materials as all‐solid‐state electrolytes for lithium‐ion batteries operate at high temperatures.

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“…[4e,6] Recently,t he well-known functional motif boron-dipyrromethene (BODIPY) was also grafted into COF pores to introduce PDT activity. [7] However,i na ll these studies,t he molecular building block selected for the structural design exhibited ROSa ctivity on their own, while inactive functional motifs were left largely unexplored. Herein, we demonstrated that, for the first time,m olecules incapable of generating ROSb y themselves can also be utilized for the construction of an extended porous framework to give efficient ROSproduction capability.Given the large variety in the choice of molecular building blocks and merits of COFs as an ew generation of nanocarriers, [8] this method provides an extra tool for the design of molecular PS to achieving desirable PDT performance.C OF-909, constructed by linking 4,4',4''-(1,4-phenylene)bis(([2,2':6',2''-terpyridine]-5,5''-dicarbaldehyde)) (L-3N), exhibited ab and gap of 1.96 eV,s howed an excellent overlap with that of the superoxide,t hus leading to drastic promotion in ROS generation performance.T he ROSg eneration rate of COF-909 is three times better than the stateof-the-art porphyrin based PSs,t etra(4-carboxyphenyl) porphyrin (TCPP).…”

mentioning

confidence: 99%

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

et al. 2019

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Covalent organic frameworks (COFs) with 2D π‐conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules, 5′,5′′′′‐(1,4‐phenylene)bis(([1,1′:3′,1′′‐terphenyl]‐4,4′′‐dicarbaldehyde)) (L‐3C) and 4,4′,4′′‐(1,4‐phenylene)bis(([2,2′:6′,2′′‐terpyridine]‐5,5′′‐dicarbaldehyde)) (L‐3N), inactive to generating reactive oxygen species (ROS), were linked to form two COFs, COF‐808 and COF‐909, respectively, exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs (surface areas 2270 and 2610 m2 g−1) promoted diffusion of both oxygen and release of ROS in cells. This, combined with the excellent photostability and biocompatibility, led to excellent PDT performance. In vitro, over 80 % of tumor cells were killed after PDT treatment using COF‐909 at the concentration of 50 μg mL−1 for 150 s. In vivo, drastic reduction of tumor size was observed (from 9 mm to less than 1 mm) after 10 day treatment.

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BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy

Cited by 140 publications

References 146 publications

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Defective 2D Covalent Organic Frameworks for Postfunctionalization

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

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