[Bmim]BF ₄ : A Versatile Ionic Liquid for the Synthesis of Diverse Bioactive Heterocycles

Abstract

Last decade has seen a tremendous applications of [bmim]BF4 (1‐butyl‐3‐methyl imidazolium tetrafluoroborate) as an efficient, cheap, commercially available, less toxic ionic liquid for the various organic transformations. On the other hand heterocycles are the privileged structural subunit of many marketed drug molecules. The present review deals with the recent applications of [bmim]BF4 as an efficient reaction medium for the synthesis of diverse biologically relevant heterocycles reported so far.

Ionic‐liquid‐promoted dual hydrogen‐bond activation strategy enabling the synthesis of diverse 2‐pyridone‐fused uracils

“…Meanwhile, we recently reported the first example of ionic-liquid-mediated umpolung hydrothiolation of ynamides. 3 In this process, ionic liquids (ILs) function as bifunctional activators bearing both hydrogen-bond (HB) donor and acceptor motifs, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] allowing simultaneous engagement with nucleophiles and electrophiles through dual HB activation in a non-covalent interaction (NCI) framework.…”

Ionic‐liquid‐promoted dual hydrogen‐bond activation strategy enabling the synthesis of diverse 2‐pyridone‐fused uracils

“…Meanwhile, we recently reported the first example of ionic-liquid-mediated umpolung hydrothiolation of ynamides. 3 In this process, ionic liquids (ILs) function as bifunctional activators bearing both hydrogen-bond (HB) donor and acceptor motifs, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] allowing simultaneous engagement with nucleophiles and electrophiles through dual HB activation in a non-covalent interaction (NCI) framework.…”

Preyssler catalyst: a heterogeneous polyacidic catalyst for the efficient synthesis of diverse bioactive heterocyclic scaffolds

“…Synthesis of pyrazoles. Gharib et al reported a facile protocol for the efficient synthesis of a series of pyrazole derivatives (22) from the reactions of various hydrazine derivatives (21) and 1,3-diketones (20) in the presence of Preyssler heteropoly acid (H14[NaP5W30O110]) as catalyst in water at room temperature (Scheme 8). 82 The solid heterogeneous catalyst was recovered easily and reused for five successive runs.…”

Magnetically Separable Transition Metal Ferrites: Versatile Heterogeneous Nano‐Catalysts for the Synthesis of Diverse Bioactive Heterocycles

“…Characterizing the synthesized nano-ZnFe 2 O 4 by SEM, TEM, XRD, EDAX, FT-IR, TGA and magnetic measurement techniques, Marzouk et al [63] used this as an efficient heterogeneous nanomagnetic catalyst for the synthesis of a series of highly functionalized imidazoles (30,31) via one-pot four component reaction of various aromatic aldehydes (1), benzyl (26), ammonium acetate (27) and 1-amino-2-propanol (28) or N,Ndimethyl-1,3-propanediamine (29) in aqueous ethanol at 80°C ( Table 7). The catalyst was recovered easily by using an external magnet and recycled five times without any significant loss in its activity.…”

Ionic‐liquid‐promoted dual hydrogen‐bond activation strategy enabling the synthesis of diverse 2‐pyridone‐fused uracils

“…Meanwhile, we recently reported the first example of ionic-liquid-mediated umpolung hydrothiolation of ynamides. 3 In this process, ionic liquids (ILs) function as bifunctional activators bearing both hydrogen-bond (HB) donor and acceptor motifs, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] allowing simultaneous engagement with nucleophiles and electrophiles through dual HB activation in a non-covalent interaction (NCI) framework.…”

Preyssler catalyst: a heterogeneous polyacidic catalyst for the efficient synthesis of diverse bioactive heterocyclic scaffolds

“…Synthesis of pyrazoles. Gharib et al reported a facile protocol for the efficient synthesis of a series of pyrazole derivatives (22) from the reactions of various hydrazine derivatives (21) and 1,3-diketones (20) in the presence of Preyssler heteropoly acid (H14[NaP5W30O110]) as catalyst in water at room temperature (Scheme 8). 82 The solid heterogeneous catalyst was recovered easily and reused for five successive runs.…”

Magnetically Separable Transition Metal Ferrites: Versatile Heterogeneous Nano‐Catalysts for the Synthesis of Diverse Bioactive Heterocycles

“…Characterizing the synthesized nano-ZnFe 2 O 4 by SEM, TEM, XRD, EDAX, FT-IR, TGA and magnetic measurement techniques, Marzouk et al [63] used this as an efficient heterogeneous nanomagnetic catalyst for the synthesis of a series of highly functionalized imidazoles (30,31) via one-pot four component reaction of various aromatic aldehydes (1), benzyl (26), ammonium acetate (27) and 1-amino-2-propanol (28) or N,Ndimethyl-1,3-propanediamine (29) in aqueous ethanol at 80°C ( Table 7). The catalyst was recovered easily by using an external magnet and recycled five times without any significant loss in its activity.…”

Ionic‐liquid‐promoted dual hydrogen‐bond activation strategy enabling the synthesis of diverse 2‐pyridone‐fused uracils

“…Meanwhile, we recently reported the first example of ionic-liquid-mediated umpolung hydrothiolation of ynamides. 3 In this process, ionic liquids (ILs) function as bifunctional activators bearing both hydrogen-bond (HB) donor and acceptor motifs, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] allowing simultaneous engagement with nucleophiles and electrophiles through dual HB activation in a non-covalent interaction (NCI) framework.…”

Preyssler catalyst: a heterogeneous polyacidic catalyst for the efficient synthesis of diverse bioactive heterocyclic scaffolds

“…Synthesis of pyrazoles. Gharib et al reported a facile protocol for the efficient synthesis of a series of pyrazole derivatives (22) from the reactions of various hydrazine derivatives (21) and 1,3-diketones (20) in the presence of Preyssler heteropoly acid (H14[NaP5W30O110]) as catalyst in water at room temperature (Scheme 8). 82 The solid heterogeneous catalyst was recovered easily and reused for five successive runs.…”

Magnetically Separable Transition Metal Ferrites: Versatile Heterogeneous Nano‐Catalysts for the Synthesis of Diverse Bioactive Heterocycles

“…Characterizing the synthesized nano-ZnFe 2 O 4 by SEM, TEM, XRD, EDAX, FT-IR, TGA and magnetic measurement techniques, Marzouk et al [63] used this as an efficient heterogeneous nanomagnetic catalyst for the synthesis of a series of highly functionalized imidazoles (30,31) via one-pot four component reaction of various aromatic aldehydes (1), benzyl (26), ammonium acetate (27) and 1-amino-2-propanol (28) or N,Ndimethyl-1,3-propanediamine (29) in aqueous ethanol at 80°C ( Table 7). The catalyst was recovered easily by using an external magnet and recycled five times without any significant loss in its activity.…”