2016
DOI: 10.18632/aging.101000
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Abstract: For the application of mesenchymal stem cells (MSCs) as clinical therapeutics, the regulation of cellular aging is important to protect hMSCs from an age-associated decline in their function. In this study, we evaluated the effects of hypoxia on cellular senescence and the immunomodulatory abilities of hUCB-MSCs. Hypoxic-cultured hUCB-MSCs showed enhanced proliferation and had increased immunosuppressive effects on mitogen-induced mononuclear cell proliferation. We found that BMI1, a member of the polycomb rep… Show more

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Cited by 21 publications
(21 citation statements)
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References 54 publications
(54 reference statements)
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“…Our study found that Bmi1 −/− mice exhibited premature osteoporosis associated with reduced MSC self‐renewal and decreased the ability to differentiate into osteoblasts . Recently, study showed that the upregulation of BMI1 induced by hypoxic‐cultures stimulated the proliferation of human umbilical cord blood‐MSCs, whereas knockdown of BMI1 in hypoxic cells inhibited their proliferation . in vitro study also showed that overexpression of BMI1 resulted in osteogenic priming of human adipose tissue‐derived MSCs under nondifferentiating conditions and enhanced osteogenesis upon differentiation, whereas knockdown of BMI1 reduced their osteogenic differentiation .…”
Section: Introductionsupporting
confidence: 51%
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“…Our study found that Bmi1 −/− mice exhibited premature osteoporosis associated with reduced MSC self‐renewal and decreased the ability to differentiate into osteoblasts . Recently, study showed that the upregulation of BMI1 induced by hypoxic‐cultures stimulated the proliferation of human umbilical cord blood‐MSCs, whereas knockdown of BMI1 in hypoxic cells inhibited their proliferation . in vitro study also showed that overexpression of BMI1 resulted in osteogenic priming of human adipose tissue‐derived MSCs under nondifferentiating conditions and enhanced osteogenesis upon differentiation, whereas knockdown of BMI1 reduced their osteogenic differentiation .…”
Section: Introductionsupporting
confidence: 51%
“…It has been shown in a previous study that the upregulation of BMI1 induced by hypoxic‐cultures stimulated the proliferation of human umbilical cord blood‐MSCs, whereas knockdown of BMI1 in hypoxic cells inhibited their proliferation in vitro . Our previous study revealed that deletion of Bmi1 in mice leads to osteopenia caused by an exhaustion of the MSC pool in the bone due to impaired the proliferation of BM‐MSCs, a consequence of upregulated p16 Ink4a /p19 Arf expression .…”
Section: Discussionmentioning
confidence: 88%
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“…Given that critical factors involved in MSC proliferation are related to the senescence of MSCs [12][13][14][15], we next investigated whether TNS3 is involved in the senescence phenotype of TMSCs by analyzing TMSCs from early (P2), intermediate (P15), and late (P28) passages after relevant consecutive subcultures. Typical phenotypes reported in replicative senescence of MSCs, including a flattened and enlarged morphology, were observed in late passage TMSCs.…”
Section: Replicatively-senescent Tmscs Exhibit the Senescence Phenotymentioning
confidence: 99%