BMI and Waist Circumference in Predicting Cardiovascular Risk Factor Clustering in Chinese Adolescents

Abstract

Research Methods and Procedures:A total of 2102 Hong Kong Chinese 12 to 19 years of age were recruited. Participants were considered to have clustering of risk factors if at least three of the following risk factors were present: 1) high-density lipoprotein cholesterol (HDL-C) Յ1.03 mM, 2) low-density lipoprotein cholesterol (LDL-C) Ն2.6 mM, 3) triglyceride (TG) Ն1.24 mM, 4) fasting plasma glucose (FPG) Ն6.1 mM, and 5) age-, sex-, and height-adjusted systolic or diastolic blood pressure (BP) Ն 90th percentile. Receiver operating characteristics (ROC) curves were generated to identify the optimal age-adjusted BMI and WC cut-off values to predict clustering of risk factors in boys and girls separately. These age-adjusted BMI and WC cut-offs were transformed to percentile values. Cole's lambda-mu-sigma (LMS) method was used to obtain smoothed age-specific BMI and WC at these percentile values. Results: The areas under ROC curves for BMI in girls and boys were 0.85 [95% confidence interval (CI), 0.77 to 0.92] and 0.76 (95% CI, 0.66 to 0.85), respectively. The respective areas under ROC curves for WC in girls and boys were 0.82 (95% CI, 0.74 to 0.91) and 0.78 (95% CI, 0.68 to 0.87). The optimal BMI thresholds were at the 78th percentile for girls and the 72nd percentile for boys. The respective values for WC were at the 77th percentile for girls and the 76th percentile for boys. The sensitivities and specificities of these cut-off values ranged from 72% to 80%. Discussion: Age-and sex-specific BMI and WC cut-off values can be used to identify adolescents with clustering of cardiovascular risk factors.

Serum concentrations of insulin-like growth factor-I, insulin-like growth factor binding protein-3 and cardiovascular risk factors in adolescents

“…19 The local percentile standards were based on the latest local population survey. 20 Subjects were considered to have clustering of cardiovascular risk factors according to the modified criteria used in the Third National Health and Nutrition Examination Survey 21 : three or more of the following risk factors HDL-C 1.03 mmol/L, LDL-C ! 2.6 mmol/L, TG !…”

Body Composition Indices and Single and Clustered Cardiovascular Disease Risk Factors in Adolescents: Providing Clinical-Based Cut-Points

“…However, future studies with a longitudinal design are needed to confirm our findings. 41 in their study with children and adolescents aged 10-15 years observed that BMI and triceps skinfold thickness accurately predicted obesity (AUCs ranged 44 . Differences between studies may be due to methodological differences in data collection or even in data preparation (i.e.…”

Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents

“…19,20 In brief, 53 schools were randomly selected from 477 secondary schools in Hong Kong using a computer-generated coding system. Of these 53 schools, 14 schools participated in the survey with consent from school principals.…”

“…19,20 Fasting blood samples were assayed for fasting plasma glucose (FPG), fasting insulin (FINS), lipids, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and calculated low-density lipoprotein cholesterol (LDL-C). Sera were also assayed for IGF-I and IGFBP-3 by an automated chemiluminescent assay system (IMMULITE 2000; Diagnostic Products Corp., Los Angeles, CA, USA).…”