Bm86 homologues and novel ATAQ proteins with multiple epidermal growth factor (EGF)-like domains from hard and soft ticks

Nijhof, Ard M.; Balk, Jesper A.; Postigo, Milagros; Rhebergen, Anne Marie; Taoufik, Amar; Jongejan, Frans

doi:10.1016/j.ijpara.2010.06.003

Cited by 48 publications

(45 citation statements)

References 33 publications

(34 reference statements)

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“…* Either RA257 or RAE/CTVM1 was used in experiments with R. appendiculatus cells** REE/CTVM28 was derived by a standard technique from embryos of a South African strain of R. evertsi (Nijhof et al 2010) and was grown at 28 °C in L15/MEM medium (Bell-Sakyi 2004). The parent R. evertsi ticks were kindly provided by Dr. Ard Nijhof and Prof. Frans Jongejan, Utrecht Centre for Tick-borne Diseases, Utrecht University, The Netherlands…”

Section: Methodsmentioning

confidence: 99%

Gene silencing in tick cell lines using small interfering or long double-stranded RNA

et al. 2012

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Section: Methodsmentioning

confidence: 99%

Gene silencing in tick cell lines using small interfering or long double-stranded RNA

et al. 2012

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“…Nijhof et al (2010) have recently identified a novel protein from metastriate ticks with structural similarities to BM86, named ATAQ after a part of its signature peptide. Although its function is unknown, ATAQ is expressed in both midguts and Malpighian tubules, while BM86 is expressed only in midguts.…”

Section: Specific Tick Antigens and Their Effect On Pathogen Transmismentioning

confidence: 99%

Tick vaccines and the control of tick-borne pathogens

Merino¹,

Alberdi²,

Lastra³

et al. 2013

Front. Cell. Infect. Microbiol.

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Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen interactions. Advances in vector and pathogen genomics and proteomics have moved forward our knowledge of the vector-pathogen interactions that take place during the colonization and transmission of arthropod-borne microbes. Tick-borne pathogens adapt from the vector to the mammalian host by differential gene expression thus modulating host processes. In recent years, studies have shown that targeting tick proteins by vaccination can not only reduce tick feeding and reproduction, but also the infection and transmission of pathogens from the tick to the vertebrate host. In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens.

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“…The Bm86 glycoprotein is located on the luminal surface of the plasma membrane of tick gut epithelial cells it is able to stimulate a protective immune response in cattle against subsequent tick infestation [23]. The phylogeny of this gene has been mainly studied in Rhipicephalus genus and obtained concordant results with data of the ticks' systematic [24].…”

Section: Introductionmentioning

confidence: 82%

Molecular and Phylogenetic Study of Bm86 Gene Ortholog from Hyalomma excavatum Tick from Tunisia: Taxonomic and Immunologic Interest

Saïd¹

2015

Hereditary Genet

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In order to assess the taxonomic and immunologic interest of Bm86 orthologs of Hyalomma ticks, partial sequence of Bm86 gene was amplified and sequenced. The sequences were isolated from three engorged Hyalomma excavatum females (Ariana strain, Tunisia). The analysis of nucleotide sequences showed increasing diversity rates of 0.26, 2.36, 4.97 and 6.02% between analyzed sequences and those isolated from H. excavatum specimen from a laboratory colony (Sousse strain, Tunisia), H. anatolicum, H. marginatum and H. scupense, respectively. The phylogenetic study showed a perfect agreement with recent data of systematic of ticks. This proves that genetic analysis of Bm86 orthologs isolated from Hyalomma ticks could be used to assist morphological diagnosis. In addition, amino-acid sequence comparison showed a high diversity rate (33-34%) between Bm86 and He86-A1/A2/A3 (Ariana strains) which can decrease the effectiveness of vaccination by commercial and experimental vaccines based on Bm86 against H. excavatum. Amino-acid diversity between Hd86-A1 used in an experimental vaccine against H. scupense and He86-A1/A2/A3 (Ariana isolates) was more limited (10.2%), thus suggesting that Hd86-A1 vaccine candidate might be more appropriate to target H. excavatum tick than corresponding Bm86 vaccines.

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Bm86 homologues and novel ATAQ proteins with multiple epidermal growth factor (EGF)-like domains from hard and soft ticks

Abstract: Graphical abstract

Cited by 48 publications

References 33 publications

Gene silencing in tick cell lines using small interfering or long double-stranded RNA

Gene silencing in tick cell lines using small interfering or long double-stranded RNA

Tick vaccines and the control of tick-borne pathogens

Molecular and Phylogenetic Study of Bm86 Gene Ortholog from Hyalomma excavatum Tick from Tunisia: Taxonomic and Immunologic Interest

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