1982
DOI: 10.1001/archderm.118.8.577
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Blue-red macules and pseudoatrophic macules: additional cutaneous signs in neurofibromatosis

Abstract: Blue-red macules and pseudoatrophic macules are characteristic skin lesions of neurofibromatosis that have been infrequently mentioned in the recent literature. The histologic characteristics of the blue-red macules show thick-walled blood vessels located mainly in the papillary dermis and often overlying subcutaneous neurofibromatous tissue. The histologic characteristics of the pseudoatrophic macules show a reduction in collagen in the reticular dermis, with diffuse replacement by neuroid tissue. These clini… Show more

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Cited by 10 publications
(7 citation statements)
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“…Similar clinical features to those in the present case can be found in the reported cases, which described a rare clinical form of cutaneous neurofibroma, pseudoatrophic macules (8)(9)(10). The pseudoatrophic macules in the reported cases were all seen in the context of NF-1.…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Similar clinical features to those in the present case can be found in the reported cases, which described a rare clinical form of cutaneous neurofibroma, pseudoatrophic macules (8)(9)(10). The pseudoatrophic macules in the reported cases were all seen in the context of NF-1.…”
Section: Discussionsupporting
confidence: 89%
“…The pseudoatrophic macules in the reported cases were all seen in the context of NF-1. Usually, the pseudoatrophic macules are slightly depressed from the surrounding skin as compared with the present case of slightly elevated plaque lesions (8)(9)(10). One reported case demonstrated a sparse amount of neoplastic cells surrounding blood vessels in the reticular dermis without involving the deeper dermis and a reduction of normal collagen bundles present in the reticular dermis, which might be attributed to the clinical appearance of the pseudoatrophic macule (8).…”
Section: Discussionmentioning
confidence: 46%
“…The first class corresponds to the classical form of NF1 with an overall mild presentation and a high prevalence of cutaneous neurofibromas 18 ; while the other two classes have more severe phenotypes. Blue‐red macules represent unusual variants of cutaneous neurofibromas, 19,20 it is therefore not surprising to find them predominate in the ‘Cutaneous neurofibromas’ class. The LC2 probably corresponds to the previously identified NF1 phenotype, coined the ‘at‐risk’ phenotype.…”
Section: Discussionmentioning
confidence: 99%
“…To the best of our knowledge, this clinical presentation of neurofibroma has rarely been reported in patients with neurofibromatosis. The lesions have been described as pseudoatrophic macules or neurofibromatous dermal hypoplasia in the literature (1–3). In 1982, Westerhof and Konrad (1) reported the case of a 19‐year‐old woman with four skin‐colored pseudoatrophic macules in which collagen of the reticular dermis was replaced diffusely by neuroid tissue and neurofibroma was confirmed.…”
Section: Discussionmentioning
confidence: 99%
“…The lesions have been described as pseudoatrophic macules or neurofibromatous dermal hypoplasia in the literature (1–3). In 1982, Westerhof and Konrad (1) reported the case of a 19‐year‐old woman with four skin‐colored pseudoatrophic macules in which collagen of the reticular dermis was replaced diffusely by neuroid tissue and neurofibroma was confirmed. In 1996, Pique et al (2) reported the case of a 19‐year‐old man with a 10 × 5 cm white‐to‐grayish pseudoatrophic macule which demonstrated features of neurofibroma, and reduction of collagen and elastic tissue in the reticular dermis on histopathologic examination.…”
Section: Discussionmentioning
confidence: 99%