Bloodstream Infections Caused by Carbapenemase-Producing Klebsiella pneumoniae Among Intensive Care Unit Patients After Orthotopic Liver Transplantation: Risk Factors for Infection and Impact of Resistance on Outcomes

Carbapenem-resistant Enterobacteriaceae in special populations: Solid organ transplant recipients, stem cell transplant recipients, and patients with hematologic malignancies

“…19 The incidence of post-SOT CRKP infection varies considerably by center and type of transplant (Table 1). [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] In general, CRKP infections occur early after transplant, with most studies reporting a median time of <50 days from transplant to infection. Reported mortality rates among SOT recipients with CRE infection generally range from 30-50%, and post-transplant CRKP infections have been associated with as much as a 10-fold risk of death.…”

“…Reported mortality rates among SOT recipients with CRE infection generally range from 30-50%, and post-transplant CRKP infections have been associated with as much as a 10-fold risk of death. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] However, a more recent cohort of 164 SOT recipients across 15 international sites confirmed that while CRE infection typically occurs in the early post-transplant period, the one-year survival rate of patients who developed CRE infection within the first year of transplant was 72%. 34 While CRKP infections remain the most common type of CRE infection in SOT recipients, infections due to carbapenem-resistant Enterobacter spp., as well as NDM-and OXA-48-producing K. pneumoniae have also been reported.…”

“…40 CRKP infections, particularly bacteremia, have been associated with a 5 to 7-fold increased risk of death in this patient population. 24,31 In one study, the mortality rates for liver transplant patients with CRKP infections was 78%, compared to 32% for carbapenem-susceptible K. pneumoniae infections (78% vs. 32%, respectively). 41,42 Kidney transplant recipients have lower rates of CRE infection than liver transplant recipients.…”

Infecções Relacionadas À Assistência À Saúde E Fatores Associados No Pós-Operatório De Transplante Hepático

“…After comparing the data of the two groups, hepatitis C and hepato-carcinoma were identified as significant factors for the development of Klebsiella pneumoniae, carbapenem resistant in liver receptors. 16 After statistical tests, the hepatitis C group had no correlation with the other variables of this study.…”

Risk factors and outcomes of carbapenem‐resistant Klebsiella pneumoniae infections in liver transplant recipients

“…4 The significant correlation between heart disease, hypertension, and CRKP colonization/ infection in intensive care units were shown by Nouvenne et al 5 They have described comorbidities, including cardiovascular, respiratory, renal, and neurological diseases, as a relevant risk factor for CRKP colonization/infection. 5 The authors analyzed transplant age, sex, ethnicity, etiology of liver disease (hepatitis C virus, alcohol, nonalcoholic fatty liver disease, hepatitis B virus, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis, acute liver failure, or other), hepatocellular carcinoma, diabetes mellitus, body mass index, median laboratory Model for End-Stage Liver Disease score, number of living donors, number of retransplantations, number of multiple organ transplants, median time on the wait list, and median cold ischemia time.…”