Blood urea nitrogen to albumin ratio is a predictor of in-hospital mortality in older emergency department patients

Dündar, Zerrin Defne; Küçükceran, Kadir; Ayrancı, Mustafa Kürşat

doi:10.1016/j.ajem.2020.10.008

Cited by 36 publications

(45 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7 Lastly, Dundar et al concluded that BAR >6.25 was an independent predictor of in-hospital mortality in all older emergency department patients (aged 65 and over). 21 The AUC of BAR in above studies varied from 0.69 to 0.83.…”

Section: Discussionmentioning

confidence: 97%

Blood Urea Nitrogen to Serum Albumin Ratio (BAR) Predicts Critical Illness in Patients with Coronavirus Disease 2019 (COVID-19)

Huang¹,

Yang²,

He³

et al. 2021

IJGM

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Blood Urea Nitrogen to Serum Albumin Ratio (BAR) Predicts Critical Illness in Patients with Coronavirus Disease 2019 (COVID-19)

Huang¹,

Yang²,

He³

et al. 2021

IJGM

View full text Add to dashboard Cite

“…In this study, the AUC and odds ratio values obtained by BAR for predicting in-hospital COVID-19 mortality were higher than the values obtained by the BUN and albumin levels. In the study conducted by Dundar et al with 1253 geriatric patients to predict the mortality of geriatric patients, they found that the AUC value and odds ratios obtained by BAR were higher than those obtained by the BUN and albumin levels [ 15 ]. In the study conducted by Ryu et al with 443 aspiration pneumonia patients to predict mortality, they found that the AUC and odds ratio values obtained by BAR were higher than those obtained by the albumin level [ 7 ].The BUN and albumin parameters are accessible parameters in emergency services, but evaluating them together by proportioning them is more valuable than evaluating them separately.…”

Section: Discussionmentioning

confidence: 99%

“…It is a parameter of the scoring system called CURB-65, which is used especially in pneumonia patients [ 8 ]. It has been shown that its level is higher in pneumonia [ 9 ], chronic obstructive pulmonary disease [ 10 ], pancreatitis [ 11 ], acute myocardial infarction [ 12 ], heart failure [ 13 ], sepsis [ 14 ], and geriatric patients [ 15 ] with mortality. There have also been studies that showed a higher BUN level in COVID-19 patients with mortality [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The role of the BUN/albumin ratio in predicting mortality in COVID-19 patients in the emergency department

Küçükceran

Ayrancı

Girişgin

et al. 2021

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

Introduction Due to the high mortality and spread rates of coronavirus disease 2019 (COVID-19), there are currently serious challenges in emergency department management. As such, we investigated whether the blood urea nitrogen (BUN)/albumin ratio (BAR) predicts mortality in the COVID-19 patients in the emergency department. Methods A total of 602 COVID-19 patients who were brought to the emergency department within the period from March to September 2020 were included in the study. The BUN level, albumin level, BAR, age, gender, and in-hospital mortality status of the patients were recorded. The patients were grouped by in-hospital mortality. Statistical comparison was conducted between the groups. Results Of the patients who were included in the study, 312(51.8%) were male, and their median age was 63 years (49–73). There was in-hospital mortality in 96(15.9%) patients. The median BUN and BAR values of the patients in the non-survivor group were significantly higher than those in the survivor group (BUN: 24.76 [17.38–38.31] and 14.43 [10.84–20.42], respectively [ p < 0.001]; BAR: 6.7 [4.7–10.1] and 3.4 [2.5–5.2], respectively [ p < 0.001]). The mean albumin value in the non-survivor group was significantly lower than that in the survivor group (3.60 ± 0.58 and 4.13 ± 0.51, respectively; p < 0.001). The area-under-the-curve (AUC) and odds ratio values obtained by BAR to predict in-hospital COVID-19 mortality were higher than the values obtained by BUN and albumin (AUC of BAR, BUN, and albumin: 0.809, 0.771, and 0.765, respectively; odds ratio of BAR>3.9, BUN>16.05, and albumin<4.01: 10.448, 7.048, and 6.482, respectively). Conclusion The BUN, albumin, and BAR levels were found to be reliable predictors of in-hospital mortality in COVID-19 patients, but BAR was found to be a more reliable predictor than the BUN and albumin levels.

show abstract

“…e UAR, novel inflammatory markers, reflect two pathways, which are probably less affected by confounding conditions and may be more predictive in evaluating the prognosis of pneumonia than urea or albumin separately [13]. Besides, as a simple and objective severity indicator for pneumonia, UAR is easy to implement in routine clinical practice when compared with the pneumonia severity index (PSI) and the CURB-65 score for pneumonia severity [14].…”

Section: Discussionmentioning

confidence: 99%

Urea-to-Albumin Ratio and In-Hospital Mortality in Severe Pneumonia Patients

Tian

Jiang

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Objective. The urea-to-albumin ratio (UAR), as a new marker of the systemic inflammatory response, is associated with the mortality in pneumonia patients. However, the association between the UAR and in-hospital mortality in severe pneumonia (SP) has received little attention. Methods. In this single-center retrospective cohort study, 212 SP patients in intensive care unit (ICU) from June 1, 2016, to June 1st, 2020, with baseline UAR were enrolled. The primary outcome was in-hospital mortality. The association of UAR with in-hospital mortality was assessed using a multivariable-adjusted Cox model. Results. Of 212 patients, the median age was 73.0 (61.0, 82.8) years, 70.8% of patients were male, and the APACHE II score was 20.0 (16.0, 26.0). During the hospital period, 101 (47.6%) patients died. In-hospital mortality rates for the lower and higher UAR were 16 (27.6%) and 85 (55.2%), respectively P < 0.001 . Kaplan–Meier analysis revealed that survival rates were significantly different between the two groups (log rank = 13.71, P < 0.001 ). After adjusted for confounding factors, the higher UAR group was significantly associated with a hazard ratio (HR) for in-hospital mortality of 2.234 (95% confidence interval: 1.146–4.356, P = 0.018 ). Besides, this pattern persisted in subgroup analyses considering sex (HR = 9.380; 95% CI: 2.248–39.138; P = 0.002 ). Conclusions. Higher UAR levels at the commencement of admission to ICU may be independently associated with increased in-hospital mortality in SP patients.

show abstract

Blood urea nitrogen to albumin ratio is a predictor of in-hospital mortality in older emergency department patients

Cited by 36 publications

References 31 publications

Blood Urea Nitrogen to Serum Albumin Ratio (BAR) Predicts Critical Illness in Patients with Coronavirus Disease 2019 (COVID-19)

Blood Urea Nitrogen to Serum Albumin Ratio (BAR) Predicts Critical Illness in Patients with Coronavirus Disease 2019 (COVID-19)

The role of the BUN/albumin ratio in predicting mortality in COVID-19 patients in the emergency department

Urea-to-Albumin Ratio and In-Hospital Mortality in Severe Pneumonia Patients

Contact Info

Product

Resources

About