Blood transfusion for treating malarial anaemia

Abstract

van den Hombergh 1996 {published data only} van den Hombergh J, Dalderop E, Smit Y. Does iron therapy benefit children with severe malaria-associated anaemia? A clinical trial with 12 weeks supplementation of oral iron in young children from the Turiani Division, Tanzania.

Targeting anemia-induced CD71 + reticulocytes protects mice from Plasmodium infection

“…Blood transfusion is often performed to treat severe anemia ( 21 ). In our study, we confirmed that blood transfusion notably corrected anemia in phlebotomy-induced anemic mice ( Fig.…”

Targeting anemia-induced CD71 + reticulocytes protects mice from Plasmodium infection

“…Blood transfusion is often performed to treat severe anemia ( 21 ). In our study, we confirmed that blood transfusion notably corrected anemia in phlebotomy-induced anemic mice ( Fig.…”

Review of available evidence supporting different transfusion thresholds in different patient groups with anemia

“…Malaria is a major health problem in many parts of the world, with an estimated one million deaths annually in severe cases . Malarial infection can result in anemia and shock.…”

“…Two systematic reviews were identified, which reviewed the two RCTs . Both concluded that there was no statistical significance in mortality between the groups, and there was increase in convulsions and coma in the transfused group (7% versus 0%) that was not statistically significant.…”

Implications of inconsistent anaemia policies for children and adolescents in Africa

“…Evidence suggested that there was no need to screen for anaemia prior to supplementation, although information on baseline Hb was limited ( 13 ) . Evidence did not support the use of Fe supplementation in HIV patients ( 14 ) or in situations where there was poor malaria surveillance and control ( 2 , 14 ) , and it did not support the use of transfusions in clinically stable children with severe anaemia ( 15 ) . Albendazole in combination with praziquantel appeared effective for improving Hb levels ( 16 ) , and vitamin A supplementation stimulated erythropoiesis in children with severe anaemia ( 17 ) .…”

Targeting anemia-induced CD71 + reticulocytes protects mice from Plasmodium infection

“…Blood transfusion is often performed to treat severe anemia ( 21 ). In our study, we confirmed that blood transfusion notably corrected anemia in phlebotomy-induced anemic mice ( Fig.…”

Review of available evidence supporting different transfusion thresholds in different patient groups with anemia

“…Malaria is a major health problem in many parts of the world, with an estimated one million deaths annually in severe cases . Malarial infection can result in anemia and shock.…”

“…Two systematic reviews were identified, which reviewed the two RCTs . Both concluded that there was no statistical significance in mortality between the groups, and there was increase in convulsions and coma in the transfused group (7% versus 0%) that was not statistically significant.…”

Implications of inconsistent anaemia policies for children and adolescents in Africa

“…Evidence suggested that there was no need to screen for anaemia prior to supplementation, although information on baseline Hb was limited ( 13 ) . Evidence did not support the use of Fe supplementation in HIV patients ( 14 ) or in situations where there was poor malaria surveillance and control ( 2 , 14 ) , and it did not support the use of transfusions in clinically stable children with severe anaemia ( 15 ) . Albendazole in combination with praziquantel appeared effective for improving Hb levels ( 16 ) , and vitamin A supplementation stimulated erythropoiesis in children with severe anaemia ( 17 ) .…”

Targeting anemia-induced CD71 + reticulocytes protects mice from Plasmodium infection

“…Blood transfusion is often performed to treat severe anemia ( 21 ). In our study, we confirmed that blood transfusion notably corrected anemia in phlebotomy-induced anemic mice ( Fig.…”

Review of available evidence supporting different transfusion thresholds in different patient groups with anemia

“…Malaria is a major health problem in many parts of the world, with an estimated one million deaths annually in severe cases . Malarial infection can result in anemia and shock.…”

“…Two systematic reviews were identified, which reviewed the two RCTs . Both concluded that there was no statistical significance in mortality between the groups, and there was increase in convulsions and coma in the transfused group (7% versus 0%) that was not statistically significant.…”

Implications of inconsistent anaemia policies for children and adolescents in Africa

“…Evidence suggested that there was no need to screen for anaemia prior to supplementation, although information on baseline Hb was limited ( 13 ) . Evidence did not support the use of Fe supplementation in HIV patients ( 14 ) or in situations where there was poor malaria surveillance and control ( 2 , 14 ) , and it did not support the use of transfusions in clinically stable children with severe anaemia ( 15 ) . Albendazole in combination with praziquantel appeared effective for improving Hb levels ( 16 ) , and vitamin A supplementation stimulated erythropoiesis in children with severe anaemia ( 17 ) .…”