Archives of Otolaryngology - Head and Neck Surgery
 1987
DOI: 10.1001/archotol.1987.01860030083014
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Blood Transfusion and Outcome in Stage III Head and Neck Carcinoma

Jonas T. Johnson1,
Floyd H. Taylor2,
P. B. Thearle3
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Cited by 53 publications

(23 citation statements)
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“…The combination of these factors has led to allogeneic blood transfusion rates commonly exceeding 40% in patients treated for advanced head and neck cancers. [3][4][5][6][7][8]10,11 The results of this study support these findings with a transfusion rate of 82.8% for preoperatively anemic patients who received a placebo. Other clinical benefits with epoetin alfa therapy in head and neck cancer patients include improved energy level, physical activity, and overall quality of life.…”
Section: Discussion
supporting
confidence: 77%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The combination of these factors has led to allogeneic blood transfusion rates commonly exceeding 40% in patients treated for advanced head and neck cancers. [3][4][5][6][7][8]10,11 The results of this study support these findings with a transfusion rate of 82.8% for preoperatively anemic patients who received a placebo. Other clinical benefits with epoetin alfa therapy in head and neck cancer patients include improved energy level, physical activity, and overall quality of life.…”
Section: Discussion
supporting
confidence: 77%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…They showed in their statistical analysis that blood transfusion increased the recurrence rate and decreased survival in patients with colorectal cancer. This finding stimulated wide research, and, later, a similar association has been observed in several other studies, especially of patients with colorectal cancer (24)(25)(26)(27)(28)(29)(30) (Table l ) , and also in patients with breast (31), lung (32,33), kidney (34)(35)(36), gastric (37), uterine cervical (38) and head and neck cancers (39) and soft tissue sarcoma (40) ( Table 2).…”
Section: 'Transplantation and Blood Transfusion
supporting
confidence: 79%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Studies have shown a more than two fold increase (71 vs. 31%) in recurrence of HNC, thought to be due to the immunomodulation and tumor‐promoting effects of blood transfusion 193,197–200 . Decreased OS, increased wound infections, flap failures, and hospital readmission rates were all found to be associated with perioperative blood transfusions 198,201–203 . A recent study published by Runge et al concluded that current transfusion practices do not increase oncologic risk or decrease OS over a 5 year period; however, this study included only a limited number of patients 204 …”
Section: Results
mentioning
confidence: 92%
“… 193 , 197 , 198 , 199 , 200 Decreased OS, increased wound infections, flap failures, and hospital readmission rates were all found to be associated with perioperative blood transfusions. 198 , 201 , 202 , 203 A recent study published by Runge et al concluded that current transfusion practices do not increase oncologic risk or decrease OS over a 5 year period; however, this study included only a limited number of patients. 204 …”
Section: Results
mentioning
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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