Blood Rheological Properties in Patients with Atopic Dermatitis (AD)

Kasperska−Zając, Alicja; Brzoza, Zenon; Koczy-Baron, E.; Jagodzinska, Julia; Słowińska, Ludmiła; Rogala, Barbara

doi:10.1007/s10753-009-9126-2

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…In adults, the declining of serum levels of DHEA with age is presumably linked with several agerelated pathologies [17,18]. In addition, positive effects such as the improvement of athletic performance, treatment of neuropsychiatric disorders, cancer, allergic diseases, viral infections and immune pathologies have been attributed to DHEA [19][20][21][22][23][24][25][26][27][28].…”

Section: Research Articlementioning

confidence: 99%

DHEA inhibits Measles Virus through a Mechanism Independent of its ability to Modulate the Raf/MEK/ERK Signaling Pathway

2012

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Aim: Despite the existence of an effective vaccine, measles infection is still frequent in many developing countries with reduced health infrastructure, and it is one of the major causes of child death globally. In the past decade numerous outbreaks have occurred in developed countries, giving a fresh impetus to antiviral research against measles virus. The aim of this study was to investigate the antiviral activity of the natural steroid hormone DHEA against measles virus and the role of the Raf/MEK/ERK signaling pathway in viral multiplication and DHEA’s antiviral activity. Materials & methods: The antiviral activity of DHEA and two ERK modulators, UO126 and anisomycin, was determined using a virus yield reduction assay. Furthermore, we studied DHEA’s virucidal activity and the viral multiplication step affected by the compound. The effect of virus infection on the Raf/MEK/ERK pathway and the activity of those compounds against measles virus spread and induced cytopathic effect were studied using western blot and indirect immunofluorescence. Results & conclusion: We found that DHEA and UO126 are active against measles virus and that they are able to diminish virus-induced cytopathic effects. Also, our study showed that early events in the viral multiplication cycle trigger ERK activation, suggesting that DHEA, a Raf/MEK/ERK modulator, may not exert its antiviral activity through the modulation of this pathway. Our results may provide a first step in the development of new antiviral agents against measles virus.

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Section: Research Articlementioning

confidence: 99%

DHEA inhibits Measles Virus through a Mechanism Independent of its ability to Modulate the Raf/MEK/ERK Signaling Pathway

2012

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“…Abnormal rheological changes induce blood clotting, irregular blood flow, and blockage of the blood vessels. The change of rheological properties of blood has been observed and correlated to diseases (such as lung cancer [ 3 ], sickle cell anemia [ 4 , 5 , 6 ], neurological disease [ 7 ], diabetes [ 8 , 9 ], chronic venous disease [ 10 ], atopic dermatitis [ 11 ], hypertension [ 12 ], and cardiovascular disease [ 13 ]). Based on the strong correlation between diseases and rheological properties [ 14 ], the mechanical properties of blood have been probed to monitor variations in the blood collected from patients.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Assessment of Red Blood Cells in Pulsatile Blood Flows

Kang

2023

Micromachines

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As rheological properties are substantially influenced by red blood cells (RBCs) and plasma, the separation of their individual contributions in blood is essential. The estimation of multiple rheological factors is a critical issue for effective early detection of diseases. In this study, three rheological properties (i.e., viscoelasticity, RBC aggregation, and blood junction pressure) are measured by analyzing the blood velocity and image intensity in a microfluidic device. Using a single syringe pump, the blood flow rate sets to a pulsatile flow pattern (Qb[t] = 1 + 0.5 sin(2πt/240) mL/h). Based on the discrete fluidic circuit model, the analytical formula of the time constant (λb) as viscoelasticity is derived and obtained at specific time intervals by analyzing the pulsatile blood velocity. To obtain RBC aggregation by reducing blood velocity substantially, an air compliance unit (ACU) is used to connect polyethylene tubing (i.d. = 250 µm, length = 150 mm) to the blood channel in parallel. The RBC aggregation index (AI) is obtained by analyzing the microscopic image intensity. The blood junction pressure (β) is obtained by integrating the blood velocity within the ACU. As a demonstration, the present method is then applied to detect either RBC-aggregated blood with different concentrations of dextran solution or hardened blood with thermally shocked RBCs. Thus, it can be concluded that the present method has the ability to consistently detect differences in diluent or RBCs in terms of three rheological properties.

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Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

et al. 2017

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Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated dermal-epidermal junction in AD patients. Instead, angiographic extensions to OCT may allow for direct measurement of vascular depth, potentially presenting a more robust method of estimating the degree of epidermal thickening.Methods and results: To investigate microcirculatory changes within AD patients, volumes of angiographic OCT data were collected from 5 healthy volunteers and compared to that of 5 AD patients. Test sites included the cubital and popliteal fossa, which are commonly affected by AD. Measurements of the capillary loop and superficial arteriolar plexus (SAP) depth were acquired and used to estimate the lower and upper bounds of the undulating basement membrane of the dermal-epidermal junction. Furthermore, quantitative parameters such as vessel density and diameter were derived from each dataset and compared between groups. Capillary loop depth increased slightly for AD patients at the poplitial fossa and SAP was found to be measurably deeper in AD patients at both sites, likely due to localized epidermal hyperplasia.Conclusions: Quantifying subtle changes within vascular morphology and depth may give clinicians an indication of the subsurface abnormalities at both involved and uninvolved AD sites.

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Blood Rheological Properties in Patients with Atopic Dermatitis (AD)

Cited by 3 publications

References 25 publications

DHEA inhibits Measles Virus through a Mechanism Independent of its ability to Modulate the Raf/MEK/ERK Signaling Pathway

DHEA inhibits Measles Virus through a Mechanism Independent of its ability to Modulate the Raf/MEK/ERK Signaling Pathway

Biomechanical Assessment of Red Blood Cells in Pulsatile Blood Flows

Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

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