Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension

Distributed Tensor Decomposition for Large Scale Health Analytics

“…In addition, we observe that most medication codes in Table 4 are associated with diagnosis codes above. For example, potassiuman chloride and practolol are commonly used to lower blood pressure in hypertensives [10, 37]. An ACE inhibitor is used primarily for the treatment of hypertension and congestive heart failure [26].…”

Distributed Tensor Decomposition for Large Scale Health Analytics

“…In addition, we observe that most medication codes in Table 4 are associated with diagnosis codes above. For example, potassiuman chloride and practolol are commonly used to lower blood pressure in hypertensives [10, 37]. An ACE inhibitor is used primarily for the treatment of hypertension and congestive heart failure [26].…”

Insights on β‐blockers for the treatment of hypertension: A survey of health care practitioners

“…The findings from this survey indicate that long‐term studies on the differential and possibly beneficial effects of newer generation β‐blockers on various clinical outcomes are warranted, particularly in prediabetic, obese, and other special populations. In particular, studies aimed at clarifying the effects of carvedilol and nebivolol would be valuable given that recent meta‐analyses suggested that BP lowering by combined β/α‐receptor blockers (ie, carvedilol) was less effective than by β 1 ‐selective blockers (ie, nebivolol) . As the most frequently used and preferred source of education by physicians in this study, CME modules and peer‐reviewed publications may provide greater benefit than other initiatives for accessible and consistent educational efforts.…”

Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

“… 56 Relative to other βBs, Cochrane reports show little difference between the drugs of interest in terms of diastolic or systolic blood pressure control. 35 , 36 However, those βBs that cross the BBB have an additional impact on central ARs. Within the CNS, norepinephrine and βARs are involved in a wide range of functions central to Alzheimer's disease pathology, including memory consolidation, synaptic plasticity, glial function and sleep.…”

“…Highly BBB-permeable βBs are less selective for β 1 ARs ( Table 1 ), which raises the possibility that the observed Alzheimer's risk reduction is driven by increased β 2 AR inhibition rather than higher BBB permeability. While both types of drug are comparably effective at controlling blood pressure, 35 , 36 β 1 -selective βBs mainly act by reducing heart rate and contractility to lower cardiac output, whereas non-selective βBs additionally induce slight peripheral vasocontraction. 71 However, the decreasing trend in risk from low to moderate to high BBB permeability argues against βB selectivity as the defining feature.…”

Distributed Tensor Decomposition for Large Scale Health Analytics

“…In addition, we observe that most medication codes in Table 4 are associated with diagnosis codes above. For example, potassiuman chloride and practolol are commonly used to lower blood pressure in hypertensives [10, 37]. An ACE inhibitor is used primarily for the treatment of hypertension and congestive heart failure [26].…”

Insights on β‐blockers for the treatment of hypertension: A survey of health care practitioners

“…The findings from this survey indicate that long‐term studies on the differential and possibly beneficial effects of newer generation β‐blockers on various clinical outcomes are warranted, particularly in prediabetic, obese, and other special populations. In particular, studies aimed at clarifying the effects of carvedilol and nebivolol would be valuable given that recent meta‐analyses suggested that BP lowering by combined β/α‐receptor blockers (ie, carvedilol) was less effective than by β 1 ‐selective blockers (ie, nebivolol) . As the most frequently used and preferred source of education by physicians in this study, CME modules and peer‐reviewed publications may provide greater benefit than other initiatives for accessible and consistent educational efforts.…”

Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

“… 56 Relative to other βBs, Cochrane reports show little difference between the drugs of interest in terms of diastolic or systolic blood pressure control. 35 , 36 However, those βBs that cross the BBB have an additional impact on central ARs. Within the CNS, norepinephrine and βARs are involved in a wide range of functions central to Alzheimer's disease pathology, including memory consolidation, synaptic plasticity, glial function and sleep.…”

“…Highly BBB-permeable βBs are less selective for β 1 ARs ( Table 1 ), which raises the possibility that the observed Alzheimer's risk reduction is driven by increased β 2 AR inhibition rather than higher BBB permeability. While both types of drug are comparably effective at controlling blood pressure, 35 , 36 β 1 -selective βBs mainly act by reducing heart rate and contractility to lower cardiac output, whereas non-selective βBs additionally induce slight peripheral vasocontraction. 71 However, the decreasing trend in risk from low to moderate to high BBB permeability argues against βB selectivity as the defining feature.…”

Distributed Tensor Decomposition for Large Scale Health Analytics

“…In addition, we observe that most medication codes in Table 4 are associated with diagnosis codes above. For example, potassiuman chloride and practolol are commonly used to lower blood pressure in hypertensives [10, 37]. An ACE inhibitor is used primarily for the treatment of hypertension and congestive heart failure [26].…”

Insights on β‐blockers for the treatment of hypertension: A survey of health care practitioners

“…The findings from this survey indicate that long‐term studies on the differential and possibly beneficial effects of newer generation β‐blockers on various clinical outcomes are warranted, particularly in prediabetic, obese, and other special populations. In particular, studies aimed at clarifying the effects of carvedilol and nebivolol would be valuable given that recent meta‐analyses suggested that BP lowering by combined β/α‐receptor blockers (ie, carvedilol) was less effective than by β 1 ‐selective blockers (ie, nebivolol) . As the most frequently used and preferred source of education by physicians in this study, CME modules and peer‐reviewed publications may provide greater benefit than other initiatives for accessible and consistent educational efforts.…”

Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

“… 56 Relative to other βBs, Cochrane reports show little difference between the drugs of interest in terms of diastolic or systolic blood pressure control. 35 , 36 However, those βBs that cross the BBB have an additional impact on central ARs. Within the CNS, norepinephrine and βARs are involved in a wide range of functions central to Alzheimer's disease pathology, including memory consolidation, synaptic plasticity, glial function and sleep.…”

“…Highly BBB-permeable βBs are less selective for β 1 ARs ( Table 1 ), which raises the possibility that the observed Alzheimer's risk reduction is driven by increased β 2 AR inhibition rather than higher BBB permeability. While both types of drug are comparably effective at controlling blood pressure, 35 , 36 β 1 -selective βBs mainly act by reducing heart rate and contractility to lower cardiac output, whereas non-selective βBs additionally induce slight peripheral vasocontraction. 71 However, the decreasing trend in risk from low to moderate to high BBB permeability argues against βB selectivity as the defining feature.…”