Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension

Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives

“…The extent of drop in peripheral BP (ie, 8/4 mm Hg) by 10 mg/d amiloride for 4 weeks in drug‐naive prehypertensive individuals was greater than what was reported by Stears and colleagues in elderly treated hypertensive patients. The greater decline in BP in our study could likely be the result of missing placebo subtraction . However, it is also possible that amiloride might be more effective for young adults who are drug‐naive vs elderly hypertensive patients who, in general, are taking multiple medications for a variety of chronic health issues.…”

Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives

“…The extent of drop in peripheral BP (ie, 8/4 mm Hg) by 10 mg/d amiloride for 4 weeks in drug‐naive prehypertensive individuals was greater than what was reported by Stears and colleagues in elderly treated hypertensive patients. The greater decline in BP in our study could likely be the result of missing placebo subtraction . However, it is also possible that amiloride might be more effective for young adults who are drug‐naive vs elderly hypertensive patients who, in general, are taking multiple medications for a variety of chronic health issues.…”

A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients

“…In fact, the current knowledge of blood pressure-lowering and cardioprotective effects of amiloride is poor even when genetic background is not taken into account. Whereas a recent meta-analysis failed to show superior blood pressure reduction with a thiazide diuretic combined with amiloride as compared to a thiazide diuretic alone [30], it has been shown that the combination with amiloride, as compared to a thiazide diuretic alone, was superior in preventing coronary mortality and sudden cardiac death [31].…”

Maximizing blood pressure lowering effects: a review of drug class comparisons and rationale for combination approaches

“…No studies were found evaluating amiloride at doses higher than 5–20 mg/day. It remains unclear whether higher doses provide additional antihypertensive effects, and the dose-response relationship cannot be determined ( 14 ).…”

Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives

“…The extent of drop in peripheral BP (ie, 8/4 mm Hg) by 10 mg/d amiloride for 4 weeks in drug‐naive prehypertensive individuals was greater than what was reported by Stears and colleagues in elderly treated hypertensive patients. The greater decline in BP in our study could likely be the result of missing placebo subtraction . However, it is also possible that amiloride might be more effective for young adults who are drug‐naive vs elderly hypertensive patients who, in general, are taking multiple medications for a variety of chronic health issues.…”

A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients

“…In fact, the current knowledge of blood pressure-lowering and cardioprotective effects of amiloride is poor even when genetic background is not taken into account. Whereas a recent meta-analysis failed to show superior blood pressure reduction with a thiazide diuretic combined with amiloride as compared to a thiazide diuretic alone [30], it has been shown that the combination with amiloride, as compared to a thiazide diuretic alone, was superior in preventing coronary mortality and sudden cardiac death [31].…”

Maximizing blood pressure lowering effects: a review of drug class comparisons and rationale for combination approaches

“…No studies were found evaluating amiloride at doses higher than 5–20 mg/day. It remains unclear whether higher doses provide additional antihypertensive effects, and the dose-response relationship cannot be determined ( 14 ).…”

Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives

“…The extent of drop in peripheral BP (ie, 8/4 mm Hg) by 10 mg/d amiloride for 4 weeks in drug‐naive prehypertensive individuals was greater than what was reported by Stears and colleagues in elderly treated hypertensive patients. The greater decline in BP in our study could likely be the result of missing placebo subtraction . However, it is also possible that amiloride might be more effective for young adults who are drug‐naive vs elderly hypertensive patients who, in general, are taking multiple medications for a variety of chronic health issues.…”

A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients

“…In fact, the current knowledge of blood pressure-lowering and cardioprotective effects of amiloride is poor even when genetic background is not taken into account. Whereas a recent meta-analysis failed to show superior blood pressure reduction with a thiazide diuretic combined with amiloride as compared to a thiazide diuretic alone [30], it has been shown that the combination with amiloride, as compared to a thiazide diuretic alone, was superior in preventing coronary mortality and sudden cardiac death [31].…”

Maximizing blood pressure lowering effects: a review of drug class comparisons and rationale for combination approaches

“…No studies were found evaluating amiloride at doses higher than 5–20 mg/day. It remains unclear whether higher doses provide additional antihypertensive effects, and the dose-response relationship cannot be determined ( 14 ).…”