Blood Pressure and Salt Appetite of Cross-Suckled Spontaneously Hypertensive and Normotensive Rats

Nicolantonio, R. Di

doi:10.1097/00004872-198708000-00005

Cited by 23 publications

(26 citation statements)

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“…The finding that genetically normotensive pups crosssuckled on SHR surrogates fail to exhibit elevated blood pressure (1,2) suggests that susceptibility to a milk agent is also required for its effect on BP. A multitude of electrolytes and hormones are found in milk (8, 9) and the factor(s) involved in cross-suckling induced hypertension is not known.…”

Section: Discussionmentioning

confidence: 99%

“…The blood pressure of SHR pups crosssuckled, from immediately after birth, onto genetically normotensive foster mothers is significantly lower than those suckled on their natural mother (1,2). However, the cross-suckling of genetically normotensive pups on to an SHR foster dam fails to alter their blood pressure at maturity (1,2). Thus some transferred maternal factor, and susceptibility to that factor, is required for full expression of the hypertension of SHR offspring.…”

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confidence: 98%

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Altered Electrolyte and Taurine Levels in Milk from Nursing Hypertensive Rats.

1993

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To examine whether milk factors play a role in the development of hypertension in the spontaneously hypertensive rat (SHR) of the Okamoto strain we have examined the levels of electrolytes and the amino acid taurine in milk from nursing SHR, Wistar Kyoto (WKY) and the stroke prone substrain of the SHR (SHR-SP). The Na+ concentration of SHR milk was significantly higher than that of the WKY and SHR-SP. The K+ concentration of SHR milk tended to be lower than that of WKY and SHR-SP and thus the Na/K ratio of SHR milk was significantly higher than that of both the SHR-SP and WKY. While taurine levels of SHR and SHR-SP milk were 29% and 28% higher than that of WKY respectively, these differences were only of borderline significance (p=0.07). The blood pressure of offspring at 8 and 12 weeks failed to correlate with milk factors within any strain. Thus while the altered levels of electrolytes in milk from SHR may play a role in the development of its hypertension the results for the SHR-SP suggests that these differences are not invariably associated with high blood pressure. (Hypertens Res 1993; 16: 179-184)

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Section: Discussionmentioning

confidence: 99%

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confidence: 98%

Altered Electrolyte and Taurine Levels in Milk from Nursing Hypertensive Rats.

1993

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“…We (39,40) and others (41) have subsequently confirmed that cross-fostering SHR pups to WKY dams consistently lowers adult blood pressure by 20-30 mmHg. In the reverse experiment, cross-fostered normotensive WKY or Sprague-Dawley pups suckled by SHR dams did not develop elevated blood pressure at maturity (37,38). As with intrauterine models of hypertension, there appears to be a critical period during which fostering is effective.…”

Section: Postnatal Programmingmentioning

confidence: 93%

“…Exposure of the young SHR to factors such as social isolation (35) and tactile stimulation (36) can alter the degree of hypertension in the adult SHR. However, the most compelling evidence that environmental factors can influence the severity of hypertension comes from the work carried out by Cierpial and McCarty (37) and DiNicolantonio (38).…”

Section: Postnatal Programmingmentioning

confidence: 99%

Perinatal development and adult blood pressure

Ashton

2000

Braz J Med Biol Res

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A growing body of evidence supports the concept of fetal programming in cardiovascular disease in man, which asserts that an insult experienced in utero exerts a long-term influence on cardiovascular function, leading to disease in adulthood. However, this hypothesis is not universally accepted, hence animal models may be of value in determining potential physiological mechanisms which could explain how fetal undernutrition results in cardiovascular disease in later life. This review describes two major animal models of cardiovascular programming, the in utero protein-restricted rat and the cross-fostered spontaneously hypertensive rat. In the former model, moderate maternal protein restriction during pregnancy induces an increase in offspring blood pressure of 20-30 mmHg. This hypertensive effect is mediated, in part, by fetal exposure to excess maternal glucocorticoids as a result of a deficiency in placental 11-ß hydroxysteroid dehydrogenase type 2. Furthermore, nephrogenesis is impaired in this model which, coupled with increased activity of the renin-angiotensin system, could also contribute to the greater blood pressure displayed by these animals. The second model discussed is the cross-fostered spontaneously hypertensive rat. Spontaneously hypertensive rats develop severe hypertension without external intervention; however, their adult blood pressure may be lowered by 20-30 mmHg by crossfostering pups to a normotensive dam within the first two weeks of lactation. The mechanisms responsible for this antihypertensive effect are less clear, but may also involve altered renal function and downregulation of the renin-angiotensin system. These two models clearly show that adult blood pressure is influenced by exposure to one of a number of stimuli during critical stages of perinatal development. Correspondence

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“…The idea of a possible link between early life experiences and vulnerability to develop hypertension was stimulated by a study indicating that cross fostering between strains could alter the likelihood of developing ''genetic'' hypertension (McMurtry, Wright, & Wexler, 1981). Although specific aspects of these original observations were not always replicated, the principle that ''genetic'' hypertension is modifiable by the early mother/infant environment has been substantiated in many subsequent studies (Azar, Kabat, & Bingham, 1991;Cierpial, Konarska, & McCarty, 1988;DiNicolantonio, Marshall, Nicolaci, & Doyle, 1986;Tang, Gandelman, & Falk, 1982). We hypothesized that quantitative variations in mother/infant interactions might be linked to individual differences in vulnerability to hypertension in the offspring much later in life.…”

Section: Introductionmentioning

confidence: 99%

Blood pressure responses to feeding in infancy: Spin‐offs of serendipity

Myers

Shair

Cohen

2005

Developmental Psychobiology

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This article summarizes results from a program of research that has focused on understanding the characteristics of, and factors that shape, acute cardiovascular responses to feeding in infants. The work developed from behavioral observations in rats suggesting a linkage between variations in maternal behavior and adult blood pressure. However, the hypothesis that specific types of interactions, in particular those associated with feeding, might alter cardiovascular function was greatly influenced by a serendipitous observation made by Myron Hofer several years earlier. Myron discovered that nutrient availability is a key regulator of cardiovascular function in newborn rats. Our spin-off studies established that, in newborn rats and human infants, ingestion of nutrient is associated with robust increases in heart rate and blood pressure.

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Blood Pressure and Salt Appetite of Cross-Suckled Spontaneously Hypertensive and Normotensive Rats

Cited by 23 publications

References 0 publications

Altered Electrolyte and Taurine Levels in Milk from Nursing Hypertensive Rats.

Altered Electrolyte and Taurine Levels in Milk from Nursing Hypertensive Rats.

Perinatal development and adult blood pressure

Blood pressure responses to feeding in infancy: Spin‐offs of serendipity

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