Blood Glucose Lowering Activities Of Seed Of Persea Americana On Alloxan Induced Diabetic Rats

Okonta, Matthew J.; Okonta, L; Aguwa, C. N.

doi:10.4314/njnpm.v11i1.11874

Cited by 4 publications

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“…This extract reduced total cholesterol levels, triglycerides and Low density lipoprotein (LDL); on the other hand, increased the levels of High density lipoprotein (HDL). The same effect was described for the aqueous extract, which also reduced blood pressure both in normal rats and those with high blood pressure; in addition, it exerted a hypoglycemic effect on rats and rabbits with diabetes [12-15]. The aqueous extract showed a median Lethal dose (LD 50 ) = 10 g/kg in rats when it was administered orally.…”

Section: Introductionmentioning

confidence: 61%

Antiprotozoal and antimycobacterial activities of Persea americana seeds

Jiménez-Arellanes

Luna-Herrera

Ruiz-Nicolás

et al. 2013

BMC Complement Altern Med

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BackgroundPersea americana seeds are widely used in traditional Mexican medicine to treat rheumatism, asthma, infectious processes as well as diarrhea and dysentery caused by intestinal parasites.MethodsThe chloroformic and ethanolic extracts of P. americana seeds were prepared by maceration and their amoebicidal, giardicidal and trichomonicidal activity was evaluated. These extracts were also tested against Mycobacterium tuberculosis H37Rv, four mono-resistant and two multidrug resistant strains of M. tuberculosis as well as five non tuberculosis mycobacterium strains by MABA assay.ResultsThe chloroformic and ethanolic extracts of P. americana seeds showed significant activity against E. histolytica, G. lamblia and T. vaginalis (IC50 <0.634 μg/ml). The chloroformic extract inhibited the growth of M. tuberculosis H37Rv, M. tuberculosis MDR SIN 4 isolate, three M. tuberculosis H37Rv mono-resistant reference strains and four non tuberculosis mycobacteria (M. fortuitum, M. avium, M. smegmatis and M. absessus) showing MIC values ≤50 μg/ml. Contrariwise, the ethanolic extract affected only the growth of two mono-resistant strains of M. tuberculosis H37Rv and M. smegmatis (MIC ≤50 μg/ml).ConclusionsThe CHCl3 and EtOH seed extracts from P. americana showed amoebicidal and giardicidal activity. Importantly, the CHCl3 extract inhibited the growth of a MDR M. tuberculosis isolate and three out of four mono-resistant reference strains of M. tuberculosis H37Rv, showing a MIC = 50 μg/ml. This extract was also active against the NTM strains, M. fortuitum, M. avium, M. smegmatis and M. abscessus, with MIC values <50 μg/ml.

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Section: Introductionmentioning

confidence: 61%

Antiprotozoal and antimycobacterial activities of Persea americana seeds

Jiménez-Arellanes

Luna-Herrera

Ruiz-Nicolás

et al. 2013

BMC Complement Altern Med

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“…The administration of aqueous extracts of T. catappa leaves and P. americana seed reduced the levels of cholesterol, TAG, LDL-chol, and increased the level of HDL-chol. The tissue extenuating or protective effects of the extracts observed by its efficacy to restore the already damaged tissue by might be due to the bioactive components which may be present in the plants (Okonta et al, 2007;Collins et al, 2018). Thus, our findings revealed that the aqueous extracts of T. catappa leaves and P. americana seed exhibited antidiabetic and its associated antihyperlipidemic activity in streptozotocin-induced diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

EXTENUATING EFFECTS OF Terminalia catappa LEAVES AND Persea americana SEED EXTRACTS ON STREPTOZOTOCIN-INDUCED LIPIDS PERTURBATION AND PANCREATIC DAMAGE IN DIABETIC RATS

Akinsanya

Onifade

2021

OJBR

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Diabetes mellitus develops either due to insufficient insulin secretion or lack of insulin resulting from damaged pancreas beta cells. Dyslipidaemia is an acute complication in diabetes mellitus. The aim of this study was to investigate the extenuating effects of T. cattapa leaves and P. americana seed aqueous extracts on streptozotocin-induced lipids profile perturbation and pancreatic damage in experimental rats. Thirty male albino rats were randomly divided into six groups (n = 5). Group 1: (negative control), group 2: 80 mg/kgbwt streptozotocin (positive control), group 3: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt T. catappa leave extract), group 4: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt Persea americana seed extract), group 5: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt extracts-mixture), group 6: (80 mg/kgbwt streptozotocin + 5 mg/kgbwt glibenclamide (standard drug). A single dose of streptozotocin was administered to the rats intraperitoneally; the extracts and glibenclamide were administered orally for 21 days, after which their pancreas was excised for histology. Thereafter, extracts of T. catappa leaves and P. americana seed on serum lipid levels imbalance in streptozotocin-induced diabetic rats were investigated. Histological studies showed a degenerative effect of the pancreatic islet cells of strotozotocin-induced groups. Results showed improvement in the regulation of lipid metabolism as well as the regeneration of the beta cells of pancreas on treatment with T. catappa leaves and P. americana seed. The extracts both equally exert significant antidyslipidemic effects in diabetic rats, in view of the extenuating effects of the extracts on pancreatic islet cells.

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“…At the moment, there are a growing researches on herbal remedies considered to be less toxic and have negligible side effect for the management of diabetes mellitus, especially in countries where access to conventional treatment of the disease is inadequate [23]. The present study evaluates the anti-diabetic effect of the leaf extracts of M. oleifera on alloxaninduced wistar albino rats with a view to providing more information on the clinical treatment of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Effects of Moringa oleifera Leaves Methanolic Extract on Alloxan- Induced Diabetic Albino Rats

Udeogu

Ejiofor

Nwakulite

2019

AJRIMPS

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Moringa oleifera, popularly known as “miracle tree” belongs to the family, Moringaceae. It is a medicinal plant in which the leaves are the most nutritious part, being a significant source of vitamins and protein among others. This study was conceived and designed based on the gaps in the research that has been performed and what is known about the plant. In this study, the effect of Moringa oleifera leaves extract on alloxan induced diabetes in Wistar albino rats was investigated. A total of forty five (45) rats were acclimatized for a period of two weeks, then randomly divided into five (5) groups (1, 2, 3, 4, and 5) of nine (9) rats each and fed with standard feed and water. Group 1 which is the control was fed with just water and standard feed while Hyperglycemia was induced in groups 2, 3, 4, & 5 intra-peritoneally after an over-night fasting using alloxan at a concentration of 130 mg/kg b.w. and allowed for 48hours which resulted in a high blood glucose level between 300 mg/dl and 600 mg/dl. Group 2 was not given any treatment while Groups 3, 4, & 5 were treated with doses 100 mg/kg b.w., 200 mg/kg bw, and 400 mg/kgbw of Moringa oleifera leaf extract respectively for a period of four weeks. A glucometer was used to check the blood glucose level of the animals before and after treatment. The results of Groups 3, 4, & 5 (172.0±4.75 mg/dl, 142.9±47.25 mg/dl, 70.6±24.46 mg/dl respectively) showed a significant decrease (p< 0.05) in blood glucose level of the induced rats when compared with Group 2 (316±47.17 mg/dl) which was induced only alloxan. It can therefore be concluded that this study has shown that the extract of Moringa oleifera leaves offers an anti-diabetic effect in Wistar albino rats.

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Blood Glucose Lowering Activities Of Seed Of Persea Americana On Alloxan Induced Diabetic Rats

Cited by 4 publications

References 0 publications

Antiprotozoal and antimycobacterial activities of Persea americana seeds

Antiprotozoal and antimycobacterial activities of Persea americana seeds

EXTENUATING EFFECTS OF Terminalia catappa LEAVES AND Persea americana SEED EXTRACTS ON STREPTOZOTOCIN-INDUCED LIPIDS PERTURBATION AND PANCREATIC DAMAGE IN DIABETIC RATS

Effects of Moringa oleifera Leaves Methanolic Extract on Alloxan- Induced Diabetic Albino Rats

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