Blood Glucose Level and Lipid Profile of Streptozotocin-induced Diabetes Rats Treated with Sodium Alginate from Sargassum crassifolium

Husni, Amir; Purwanti, Dwi; Ustadi,

doi:10.3923/jbs.2016.58.64

Cited by 19 publications

(20 citation statements)

References 14 publications

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“…Furthermore, the observed molecular perturbation perhaps may also cause impairment of TRPM2 (transport receptor potential cation channel melastatin-related subfamily member 2) channel which plays a critical role in mediating oxidative-stressinduced cell death, thereby, contributing to the pathogenesis of higher blood glucose level. In contrast to the present findings, some studies have reported that plasma postprandial glucose level of control group (normal rats) showed a negligible change during the experimental period [8,48]. However, these were largely studies at age 15 days.…”

Section: Discussioncontrasting

confidence: 99%

“…It has also been used as a folk remedy for a verity of ailments/ disorders. Allium cepa has been found as a source of a complex mixture of sulphur compounds that possess bioactive properties such as quercetin, fructose, quercetin-3-glucoside, isorhamnetin-4-glucoside, xylose, galactose, glucose, mannose, organosulfur compounds, allylsulfides, flavonoids, flavenols, S-alk(en)yl cysteine sulfoxides, cycloalliin, selenium, thiosulfinates, sulfur, seleno, vitamins and some minerals [8][9][10][11][12][13][14]. Allium cepa has potential as an anticancer, antidiabetic, antimicrobial, antihypertensive, antioxidant [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress

An¹

2018

IJBP

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Allium cepa Linn, botanicals, Liliaceae (family) commonly known as onion, and coffee are special delicacies, and conventional as functional foods that contain physiologically active ingredients that for centuries have been exploited as folk remedies for the treatment of diseases. The present study was conducted to evaluate the therapeutic efficacies and the possible participation of oxidative stress of Nigerian Allium cepa and coffee such as antioxidant, antihyperglycaemic, hypoglycaemic, hyperglycaemic in normal experimental wistar rats. Materials and Methods: qualitative phytochemical screening of hydromethanolic extract of Allium cepa was carried out for the identifications of the phytoconstituents. Hydromethanolic extract of Allium cepa 100mg kg -1, vitamin E 400mg kg -1, and coffee 500mg kg-1, combinations of Allium cepa and coffee and vitamin E and coffee respectively, administered orally to each group of rats daily. During the experimental periods glucose concentrations were estimated at baseline 0 (time of treatment ingestion), age 21 and 42 days respectively, with corresponded oxidative stress markers -superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malondialdehyde (MDA) analyzed at age 42 days. Results:Result ranked time-dependent (in days) glucose lowering potential of treatments as: -Allium cepa + coffee > Allium cepa > vitamin E > coffee + vitamin E; with corresponded up regulated of SOD, CAT, GPx and GSH and reduced MDA. Conversely, coffee and control group (normal rats) significantly in time -dependent, raised blood glucose level with corresponded increase in MDA with respect to other biomarkers, suggesting lipid peroxidation oxidative stress induced impairment of cellular antioxidant protective system. Conclusion:It can be concluded that synergistic effect, presence of the additive bioactive phytoconstituents, and/or antioxidant efficacies or both, and potentiation action of several compounds in Allium cepa and coffee combined , over time, offer the intrinsic antioxidant defence system much better defensive mechanism to protect against free radicals, and alleviate the toxic effects of accumulation of reactive oxygen species (ROS); thence providing protective mechanisms against the development of elevated blood sugar levels. Evidently, Allium cepa and coffee combined is Research ArticleVolume 3 Issue 1

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress

An¹

2018

IJBP

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“…The administration of SHE in this study can also decrease triglyceride levels at day 15. Moreover, sodium alginate from S. crassifolium and S. polycystum can decrease triglyceride levels in STZ-induced hyperglyceride rats ( 21 , 22 ).…”

Section: Resultsmentioning

confidence: 99%

“…A decrease in cholesterol levels by Sargassum wightii extract was also shown by Mohapatra et al ( 23 ) in type 2 diabetic mice with a high-fat diet and STZ induction. Husni et al ( 21 ) stated that sodium alginate from S. crassifolium at a dose of 600 mg/kg could lower cholesterol levels equally well with glibenclamide drugs in STZ-induced rats. The ability of Na-alginate as a reducer of cholesterol in diabetic rats was also obtained from T. ornata ( 20 ), in contrast to Husni et al ( 22 ), who stated that S. polycystum extract had no effect on the cholesterol levels of diabetic rats induced by STZ.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic Activity of Sargassum hystrix Extracts in Streptozotocin-Induced Diabetic Rats

Gotama¹,

Husni²

2018

pnf

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The objective of this research was to determine the potential effects of Sargassum hystrix extracts (SHE) on the glucose levels, lipid profile, and pancreas of streptozotocin (STZ)-induced diabetic rats. SHE at 200, 300, and 400 mg/kg was administered orally to STZ-induced diabetic rats once daily for 15 days. Glucose levels, lipid profile, and weight of rats were measured in the normal state and on the 15th day. The histology of the pancreas was observed on the 15th day. The results showed that the preprandial and postprandial glucose levels in the group treated with SHE at 300 mg/kg were significantly reduced compared with those of the diabetes group. Additionally, the levels of triglycerides and cholesterol in the 300 mg/kg SHE group were significantly different from those in the diabetes group. However, the levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol across the treatment groups did not have significant differences. Necrosis was found in all STZ-induced rats. SHE at a dose of 300 mg/kg had the best capability to lower the levels of preprandial and postprandial glucose and to prevent necrosis in diabetic rats.

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“…6b ). This indicated that the drug is only an inhibitor of α-glucosidase at intestinal microvilli and perhaps at higher dosage of the drug was inhibiting α-glucosidase activity at an increased level and eventually decreasing the levels of blood glucose which resulted in the activation of hyperglycemic hormones for the maintenance of glucose levels 30 , 31 . Insulin levels dropped sharply after the administration of Streptozotocin, however, moderate improvement in the level of insulin was observed with 3c after the treatment period (Fig.…”

Section: Resultsmentioning

confidence: 99%

A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies

Luthra

Agarwal

Mamidala

et al. 2017

Sci Rep

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α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-glucosidase. The design was validated through molecular docking that revealed strong binding interactions of the newly designed compounds against α-glucosidase. A library comprising of 15 compounds was synthesized in a combinatorial fashion, where the advanced amide intermediates were accessed through “shot gun” synthesis. The final compounds were characterized by 1H, 13C-NMR and with high resolution mass spectroscopy. In vitro screening of the compounds against yeast α-glucosidase revealed substantial inhibition with IC50s in the range of 4–10 μM (the standard drug acarbose inhibits α-glucosidase with an IC50 of 9.95 μM). Reaction kinetics suggested mixed type inhibition. Finally, in vivo studies of the most active compound 3c against Streptozotocin induced male albino Wistar rats revealed that its administration in the rats for about 4 weeks lead to a highly significant (P < 0.001) decrease in the fasting blood glucose (FBG) compared to the untreated diabetic rats. Moreover, lower dose of 3c had better control over FBG in contrast to high-dose.

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Blood Glucose Level and Lipid Profile of Streptozotocin-induced Diabetes Rats Treated with Sodium Alginate from Sargassum crassifolium

Cited by 19 publications

References 14 publications

Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress

Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress

Antidiabetic Activity of Sargassum hystrix Extracts in Streptozotocin-Induced Diabetic Rats

A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies

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