Blood factors as biomarkers in osteoporosis: points from the COVID-19 era

Salamanna, Francesca; Maglio, Melania; Borsari, Veronica; Landini, Maria Paola; Fini, Milena

doi:10.1016/j.tem.2021.05.005

Cited by 9 publications

(6 citation statements)

References 66 publications

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“…According to platelet count and related indicators, PLT was significantly higher in the NoV infection than in the non-infection group. This profile is relatively different from SARS-CoV-2, but similar to HCV, HIV infection, and other gastrointestinal virus infections, such as enterovirus [23][24][25][26][27][28]. It has been reported that PLT was significantly increased in children with EV71 infection, which serve as immune regulatory cells that affect the pathogenesis of virus infection.…”

Section: Discussionmentioning

confidence: 94%

“…Moreover, it suggests that the predictive model we constructed for the risk assessment of NoV infection has a better clinical predictive performance. The risk prediction model was constructed using multivariate logistic regression analysis and incorporated routine laboratory blood indicators as well as common symptoms and clinical signs [ 23 , 24 ]. We then correlated the valid routine blood indicators in the model with different degrees of symptoms and clinical treatments.…”

Section: Discussionmentioning

confidence: 99%

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Development and validation of an efficient nomogram for risk assessment of norovirus infection in pediatric patients

Chen

Deng

et al. 2022

Eur J Clin Microbiol Infect Dis

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This study aimed to establish a predictive model and nomogram based on routine laboratory blood indicators and clinical symptoms, subsequently providing a rapid risk assessment of norovirus (NoV) infection in children. This retrospective study enrolled 307 pediatric patients with symptoms of acute gastroenteritis and detected NoV using real-time quantitative polymerase chain reaction. Significant indicators selected by multivariate logistic regression, including routine blood tests and consultation symptoms, were used to develop the nomogram. We divided the sample into training and internal validation sets and performed external validation of the final model. Furthermore, we evaluated the clinical performance using the Akaike information criterion (AIC), area under the curve (AUC), calibration curve, decision curve analysis (DCA), sensitivity, specificity, concordance rate, positive predictive value, and negative predictive value. Overall, 153 cases were NoV-PCR-positive, and 154 were negative. The multivariate logistic regression included five predictors of NoV infection, including symptoms of vomiting, upper respiratory tract infection, and indicators of white blood cells, lymphocyte absolute counts, and platelet counts. The nomogram showed a significant predictive value with overall internal set diagnosis, with an AUC of 0.827 (95% confidence interval (CI): 0.785–0.868), and 0.812 (95% CI: 0.755–0.869) with 0.799 (95% CI: 0.705–0.894) in the training and internal validation sets, respectively. Nevertheless, the AUC in the external validation set was higher (0.915; 95% CI: 0.862–0.968). This nomogram is a useful tool for risk assessment for NoV infection. Moreover, the evaluated indicators are accessible, substantially reducing the time for laboratory testing.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Development and validation of an efficient nomogram for risk assessment of norovirus infection in pediatric patients

Chen

Deng

et al. 2022

Eur J Clin Microbiol Infect Dis

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“…The shared DEGs were also highly enriched in the platelet alpha granule (6 genes) and platelet alpha granule lumen (4 genes) CC terms. Platelet alpha granules impact endothelial exocytosis and OP development, and platelets play a well-documented role in regulating bone remodeling and vascular function ( Li et al, 2021 ; Salamanna et al, 2021 ). The top MF terms in which these shared DEGs were enriched included calcium-dependent phospholipid binding (3 genes) and CXCR chemokine receptor binding (2 genes).…”

Section: Discussionmentioning

confidence: 99%

The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study

Kang

Wen

Liang

et al. 2022

Front. Cell Dev. Biol.

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The COVID-19 pandemic caused by the severe acute coronavirus disease 2 (SARS-CoV-2) virus represents an ongoing threat to human health and well-being. Notably, many COVID-19 patients suffer from complications consistent with osteoporosis (OP) following disease resolution yet the mechanistic links between SARS-CoV-2 infection and OP remain to be clarified. The present study was thus developed to explore the potential basis for this link by employing transcriptomic analyses to identify signaling pathways and biomarkers associated with OP and SARS-CoV-2. Specifically, a previously published RNA-sequencing dataset (GSE152418) from Gene Expression Omnibus (GEO) was used to identify the differentially expressed genes (DEGs) in OP patients and individuals infected with SARS-CoV-2 as a means of exploring the underlying molecular mechanisms linking these two conditions. In total, 2,885 DEGs were identified by analyzing the COVID-19 patient dataset, with shared DEGs then being identified by comparison of these DEGs with those derived from an OP patient dataset. Hub genes were identified through a series of bioinformatics approaches and protein-protein interaction analyses. Predictive analyses of transcription factor/gene interactions, protein/drug interactions, and DEG/miRNA networks associated with these DEGs were also conducted. Together, these data highlight promising candidate drugs with the potential to treat both COVID-19 and OP.

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“…During the pandemic, the use of osteoporosis medications is safe and effective and should go on as usual [ 78 ]. Salamanna et al discovered that platelet (PLT) count and monocyte-related factors could be used as biomarkers for screening, diagnosing, and monitoring OP in both sexes at these times [ 79 ]. Numerous biological and clinical mechanisms connect bone metabolism and inflammation.…”

Section: Management Of Osteoporosis In Covid-19 Pandemicmentioning

confidence: 99%

COVID-19 Pandemic and Osteoporosis in Elderly Patients

Tang¹

2022

Aging and disease

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Coronavirus disease 2019 (COVID-19), which is caused by an infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly becoming a worldwide epidemic and poses a significant threat to human life and health. SARS-CoV-2 can cause damage to organs throughout the body through ACE2 receptors. It may have direct and indirect effects on osteoclasts, and osteoblasts and lead to osteoporosis. Vitamin D (VitD) is a key hormone for bone health and has immunomodulatory actions of relevance in the context of the COVID-19 pandemic. Vitamin D deficiency has a significant positive association with both infection and the mortality rate of COVID-19. Elderly patients infected by COVID-19 were more likely to develop acute respiratory distress syndrome (ARDS), which was primarily caused by an inflammation storm. The production of proinflammatory cytokines increases with COVID-19 infection and immobilization may result in bone loss and bone resorption in seriously ill patients, especially aging patients. It is well known that glucocorticoids are beneficial in the treatment of acute respiratory distress syndrome (ARDS) because they reduce inflammation and improve the functioning of the lung and extrapulmonary organs. Glucocorticoid therapy is widely used to treat patients with COVID-19 in most parts of the world. During COVID-19 clinical treatment, glucocorticoids may accelerate bone loss in elderly people, making them more susceptible to the development of osteoporosis. Therefore, it is worthwhile to draw the attention of clinicians and researchers to the linkages and interactions between COVID-19, glucocorticoids, and osteoporosis (especially in elderly patients).

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Blood factors as biomarkers in osteoporosis: points from the COVID-19 era

Cited by 9 publications

References 66 publications

Development and validation of an efficient nomogram for risk assessment of norovirus infection in pediatric patients

Development and validation of an efficient nomogram for risk assessment of norovirus infection in pediatric patients

The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study

COVID-19 Pandemic and Osteoporosis in Elderly Patients

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