Blood Factor in Acute Disseminated Lupus Erythematosus

Haserick, John R.

doi:10.1001/archderm.1950.01530130007002

Cited by 40 publications

(7 citation statements)

References 1 publication

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“…factor in Cohn's Fraction II (27) was confirmed. In agreement with reports (3)(4)(5) that the L.E. factor is associated with the serum gamma-globulin, Fraction II, which represents the bulk of the gamma-globulin, and Fraction III, which contains a small amount of gamma-globulin (Table I), were the only serum fractions found to contain L.E.…”

Section: Resultssupporting

confidence: 92%

Studies on Desoxyribonuclease in Systemic Lupus Erythematosus. Non-Participation of Serum Desoxyribonuclease in the “L.E. Phenomenon” 1

Kurnick¹,

Pariser²,

Schwartz³

et al. 1952

J. Clin. Invest.

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Section: Resultssupporting

confidence: 92%

Studies on Desoxyribonuclease in Systemic Lupus Erythematosus. Non-Participation of Serum Desoxyribonuclease in the “L.E. Phenomenon” 1

Kurnick¹,

Pariser²,

Schwartz³

et al. 1952

J. Clin. Invest.

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“…Even in the absence of immunoglobulin, and just following the induction of apoptosis by sodium arsenate, significant numbers of LE-cells were observed. This is in direct contradiction to the LE-cell phenomenon's wellestablished requirement for immunoglobulin and complement [34,35]. Thus, these results are unlikely to constitute what is commonly defined as the LE-cell phenomenon.…”

Section: Discussioncontrasting

confidence: 59%

Engulfed cell remnants, and not cells undergoing apoptosis, constitute the LE-cell phenomenon

et al. 2007

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The LE cell has been one of the first immunological signs of active systemic lupus erythematosus, included into the ACR criteria. LE cells consist of a phagocyte engulfing material of disputed origin, which was interpreted as either cellular remnants from necrotic cells or as early apoptotic cells. It is well established that LE cell formation is dependent on autoantibodies against the linker histone H1. In view of this fact, we investigated whether anti-histone H1 antibodies and LE cell positive sera bound to cells where apoptosis had been induced by gliotoxin or actinomycin D or which were necrotic after heating. Necrotic cell remnants, but not (early) apoptotic cells were bound by anti-histone H1 antibodies and LE cell positive sera, establishing that the process of LE cell formation, which is dependent on anti-H1 binding, leads to engulfment of necrotic (or late apoptotic) material, but not of early apoptotic cells.

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“…We suggest that the L.E. plasma factor (27), which itself has no DNase activity (5), causes the release of the intracellular DNase from inhibition. The inhibition of the "L.E.…”

Section: Discussionmentioning

confidence: 84%

A Specific Inhibitor for Human Desoxyribonuclease and an Inhibitor of the Lupus Erythematosus Cell Phenomenon From Leucocytes 1

Kurnick¹,

Schwartz²,

Pariser³

et al. 1953

J. Clin. Invest.

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In speculating upon the probable role of desoxyribonuclease (DNase) in the depolymerization of desoxyribonucleic acid (DNA), which characterizes (1) the "lupus erythematosus (L.E.) cell" (2), we have suggested (3), as have Klemperer and his associates (4), that an increased serum enzyme activity, potentiation of an intracellular DNase, or destruction of an intracellular inhibitor of DNase by a serum factor, might be responsible. In a previous communication (5) we reported evidence which excludes the serum DNase from responsibility for the phenomenon. Studies on the interaction of leucocytes and serum, in an approach to the alternative possibilities, disclosed the presence of a specific intracellular inhibitor of human serum DNase and an inhibitor of the "L.E.cell" phenomenon (6, 7). In the present paper, we shall report upon some of the characteristics of these factors.

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Blood Factor in Acute Disseminated Lupus Erythematosus

Cited by 40 publications

References 1 publication

Studies on Desoxyribonuclease in Systemic Lupus Erythematosus. Non-Participation of Serum Desoxyribonuclease in the “L.E. Phenomenon” 1

Studies on Desoxyribonuclease in Systemic Lupus Erythematosus. Non-Participation of Serum Desoxyribonuclease in the “L.E. Phenomenon” 1

Engulfed cell remnants, and not cells undergoing apoptosis, constitute the LE-cell phenomenon

A Specific Inhibitor for Human Desoxyribonuclease and an Inhibitor of the Lupus Erythematosus Cell Phenomenon From Leucocytes 1

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