Blood concentrations of methionine, selenium, beta-carotene, and other micronutrients in a case–control study of arsenic-induced skin lesions in West Bengal, India

Chung, Joyce; Haque, Reina; Mazumder, D. N. Guha; Moore, Lee E.; Ghosh, Nilima; Samanta, Sujay; Mitra, Soma; Hira-Smith, Meera; Ehrenstein, Ondine von; Basu, Arindam; Liaw, Jane; Smith, Allan H.

doi:10.1016/j.envres.2005.10.006

Cited by 45 publications

(29 citation statements)

References 41 publications

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“…In another case-control study in West Bengal, odds ratios for arsenicrelated skin lesions did not differ by blood selenium levels (21). It is unclear, however, whether the blood selenium levels observed in cases were a consequence or a contributing factor to blackfoot disease or arsenic-related skin lesions in these case-control analyses.…”

Section: Discussionmentioning

confidence: 93%

“…Additionally, animal studies have shown an interaction between selenium and arsenic, such that uptake of one of these elements causes release, redistribution, or elimination of the other element by urinary and/or biliary routes (16,17). However, findings from epidemiologic studies about the protective effect of selenium intake on risks of arsenic-related diseases, such as premalignant skin lesions and blackfoot disease (a unique peripheral vascular disease in lower extremities related to high levels of arsenic exposure), in populations exposed to arsenic exposure have been inconclusive (13,(18)(19)(20)(21). Limitations of these studies include small sample sizes, unavailability of prediagnostic selenium levels (in observational studies), and methodologic shortcomings, such as the lack of blindness in randomization (in intervention studies).…”

Section: Introductionmentioning

confidence: 99%

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A Prospective Study of Blood Selenium Levels and the Risk of Arsenic-Related Premalignant Skin Lesions

Chen

Hall

Graziano

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

105

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Arsenic exposure from drinking water is considered to be a risk factor for skin and internal cancers. Animal studies suggest a potential antagonism between arsenic and selenium in the body. We did a case-cohort analysis to prospectively evaluate the association between arsenic-related premalignant skin lesions and prediagnostic blood selenium levels in 303 cases of skin lesions newly diagnosed from November 2002 to April 2004 and 849 subcohort members randomly selected from the 8,092 participants in the Health Effects of Arsenic Longitudinal Study with available baseline blood and urine samples collected in 2000. Incidence rate ratios for skin lesions in increasing blood selenium quintiles were 1.00 (reference), 0.68 [95% confidence interval (95% CI), 0.39-1.18], 0.51 (95% CI, 0.29-0.87), 0.52 (95% CI, 0.30-0.91), and 0.53 (95% CI, 0.31-0.90). Effect estimates remained similar with adjustments for age, sex, body mass index, smoking status, excessive sunlight exposure (in men), well water arsenic concentration at baseline, and nutritional intakes of folate, iron, protein, vitamin E, and B vitamins. At any given arsenic exposure level, the risk of premalignant skin lesions was consistently greater among participants with blood selenium lower than the average level. The findings support the hypothesis that dietary selenium intake may reduce the incidence of arsenicrelated premalignant skin lesions among populations exposed to arsenic exposure from drinking water. (Cancer Epidemiol Biomarkers Prev 2007;16(2):207 -13)

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

A Prospective Study of Blood Selenium Levels and the Risk of Arsenic-Related Premalignant Skin Lesions

Chen

Hall

Graziano

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

105

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“…To simulate at least one aspect of the physiological conditions, the solution of L-methionine was used containing the physiological levels (20 μM) of this significant sulfur-containing biomolecule [25].…”

Section: Interactions Of the Selected Complexes 7 And 12 With L-methimentioning

confidence: 99%

N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes

et al. 2013

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Abstract:The platinum(II) complexes trans-[PtCl 2 (L n ) 2 ]·xSolv 1-13 (Solv = H 2 O or CH 3 OH), involving N6-benzyladenosine-based N-donor ligands, were synthesized; L n stands for N6-(2-methoxybenzyl)adenosine (L 1 , involved in complex 1), , 11), 2-chloro-N6-(2-hydroxy-3-methoxybenzyl)adenosine (L 12 , 12) and 2-chloro-N6-(2-hydroxy-5-methylbenzyl)adenosine (L 13 , 13). The compounds were characterized by elemental analysis, mass spectrometry, IR and multinuclear ( N-) and two-dimensional NMR spectroscopy, which proved the N7-coordination mode of the appropriate N6-benzyladenosine derivative and trans-geometry of the title complexes. The complexes 1-13 were found to be non-toxic in vitro against two selected human cancer cell lines (HOS and MCF7; with IC 50 > 50.0 µM). However, they were found (by ESI-MS study) to be able to interact with the physiological levels of the sulfur-containing biogenic biomolecule L-methionine by a relatively simple 1:1 exchange mechanism (one L n molecule was replaced by one L-methionine molecule), thus forming a mixed-nitrogen/sulfur-ligand dichlorido-platinum(II) coordination species.

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“…The clinical features are characterized by hyper-and hypo-pigmentation, keratosis and various systemic manifestations like weakness, anaemia, chronic lung disease, peripheral neuropathy, liver fibrosis, gangrene of the limbs and cancers of the skin, lung and urinary bladder (6)(7)(8) . Studies on populations in Taiwan, India and Argentina exposed to arsenic through drinking water have suggested that malnutrition increases the risk of arsenic-induced diseases (9)(10)(11)(12)(13) . Several human studies have identified associations between malnutrition and arsenicinduced skin lesions, skin cancer and cardiovascular effects (12,14) .…”

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confidence: 99%

Nutritional deficiency and arsenical manifestations: a perspective study in an arsenic-endemic region of West Bengal, India

Deb

Biswas

Ghose

et al. 2012

Public Health Nutr.

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Objective: To assess whether nutritional deficiency increases susceptibility to arsenic-related health effects. Design: Assessment of nutrition was based on a 24 h recall method of all dietary constituents. Setting: Epidemiological cross-sectional study was conducted in an arsenicendemic area of West Bengal with groundwater arsenic contamination. Subjects: The study was composed of two groups -Group 1 (cases, n 108) exhibiting skin lesions and Group 2 (exposed controls, n 100) not exhibiting skin lesions -age-and sex-matched and having similar arsenic exposure through drinking water and arsenic levels in urine and hair. Results: Both groups belonged to low socio-economic strata (Group 1 significantly poorer, P , 0?01) and had low BMI (prevalence of BMI , 18?5 kg/m 2 : in 38 % in Group 1 and 27 % in Group 2). Energy intake was below the Recommended Daily Allowance (set by the Indian Council of Medical Research) in males and females in both groups. Increased risk of arsenical skin lesions was found for those in the lowest quintile of protein intake (v. highest quintile: OR 5 4?60, 95 % CI 1?36, 15?50 in males; OR 5 5?62, 95 % CI 1?19, 34?57 in females). Significantly lower intakes of energy, protein, thiamin, niacin, Mg, Zn and choline were observed in both males and females of Group 1 compared with Group 2. Significantly lower intakes of carbohydrate, riboflavin, niacin and Cu were also observed in female cases with skin lesions compared with non-cases. Conclusions: Deficiencies of Zn, Mg and Cu, in addition to protein, B vitamins and choline, are found to be associated with arsenical skin lesions in West Bengal. Keywords Arsenic manifestations Energy intake Micronutrients ProteinArsenic exposure through drinking water is a major health problem affecting many countries such as Bangladesh,

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Blood concentrations of methionine, selenium, beta-carotene, and other micronutrients in a case–control study of arsenic-induced skin lesions in West Bengal, India

Cited by 45 publications

References 41 publications

A Prospective Study of Blood Selenium Levels and the Risk of Arsenic-Related Premalignant Skin Lesions

A Prospective Study of Blood Selenium Levels and the Risk of Arsenic-Related Premalignant Skin Lesions

N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes

Nutritional deficiency and arsenical manifestations: a perspective study in an arsenic-endemic region of West Bengal, India

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