Blood-clotting mimetic behavior of biocompatible microgels

Birajdar, Mallinath S.; Halake, Kantappa; Lee, Jonghwi

doi:10.1016/j.jiec.2018.02.007

Cited by 16 publications

(8 citation statements)

References 36 publications

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“…On the other hand, catechol group-containing materials can present tissue adhesiveness , and enhanced blood cell/platelet adhesion and activation, and catechol group- or polydopamine-containing hydrogels and nanoparticles have been demonstrated to improve the blood-clotting capacity. , In addition, catechol group- or polydopamine-containing biomaterials possess excellent antioxidant ability because of their existence of reductive groups and conduciveness to enhance wound-healing process by balancing the oxidation/reduction of the wound microenvironment . Biomaterials associated with catechol derivatives exhibit good biocompatibility, and polydopamine-based biomaterials can also be degraded. , Thus, we anticipate that developing biodegradable cryogel hemostat based on gelatin and polydopamine will present huge potential to stop deep noncompressible wound bleeding and simultaneously promote wound healing, which has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing

et al. 2020

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Biodegradable cryogel wound dressing which can stop deep noncompressible hemorrhage and simultaneously promote wound healing is a highly promising biomaterial in clinics. Here, we prepared a series of biodegradable interpenetrating polymer network (IPN) dry cryogel hemostats by cryopolymerization of gelatin and dopamine. The IPN structure of cross-linked gelatin and polydopamine endows the cryogels good injectability, robust mechanical property, and shape memory property. The cryogels showed better whole bloodclotting capacity and more blood cell and platelet adhesion and activation than gauze and gelatin hemostatic sponge. The cryogels present less blood loss and shorter hemostasis time than gauze and gelatin hemostatic sponges in the mouse liver trauma model, rat liver incision model, and rabbit liver cross incision model. Especially, the hemostatic effect of the cryogel on deep narrow noncompressible hemorrhage was determined by the rabbit liver defect deep narrow noncompressible hemorrhage model. The cryogel rapidly stopped deep massive noncompressible hemorrhage in the swine subclavian artery and vein complete transection model. Besides, the component of polydopamine endows cryogels with excellent antioxidant activity and NIR irradiationassisted photothermal antibacterial ability. Gelatin/dopamine cryogels were more effective in promoting wound healing than Tegaderm films. The developed biodegradable cryogels with a simple preparation process and low cost and which can be easily carried and used present huge potential as novel wound dressing for rapid hemostasis and promoting wound healing.

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Section: Introductionmentioning

confidence: 99%

Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing

et al. 2020

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“…[ 33 ] Hence, researchers have developed varying bioactive material containing catechol group or dopamine to enhance blood coagulation. [ 34 ] For example, Huang et al developed a hemostatic agent, a biodegradable interpenetrating polymer network (IPN) dry cryogel derived from the cryo‐polymerization of gelatin and dopamine ( Figure 2 ). [ 35 ] Another experiment demonstrated its superior hemostatic property to medical gauze and commercially available PVA sponge and better wound healing results than Tegaderm film, a commercial product commonly used in clinical practice.…”

Section: Accelerated Wound Healing Via Cell Behavior Modulation Of Bi...mentioning

confidence: 99%

Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Huang

et al. 2022

Advanced Science

149

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Skin wound repair is a multistage process involving multiple cellular and molecular interactions, which modulate the cell behaviors and dynamic remodeling of extracellular matrices to maximize regeneration and repair. Consequently, abnormalities in cell functions or pathways inevitably give rise to side effects, such as dysregulated inflammation, hyperplasia of nonmigratory epithelial cells, and lack of response to growth factors, which impedes angiogenesis and fibrosis. These issues may cause delayed wound healing or even non-healing states. Current clinical therapeutic approaches are predominantly dedicated to preventing infections and alleviating topical symptoms rather than addressing the modulation of wound microenvironments to achieve targeted outcomes. Bioactive materials, relying on their chemical, physical, and biological properties or as carriers of bioactive substances, can affect wound microenvironments and promote wound healing at the molecular level. By addressing the mechanisms of wound healing from the perspective of cell behaviors, this review discusses how bioactive materials modulate the microenvironments and cell behaviors within the wounds during the stages of hemostasis, anti-inflammation, tissue regeneration and deposition, and matrix remodeling. A deeper understanding of cell behaviors during wound healing is bound to promote the development of more targeted and efficient bioactive materials for clinical applications.

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“…Hydrogels composed of hyaluronic acid and chitosan have been used to deliver the angiogenic promoting growth factor vascular endothelial growth factor (VEGF) and have been shown to be both antibacterial and angiogenic, suggesting it might have potential as a wound healing therapeutic [22]. Furthermore, hydrogels that have incorporated hyaluronan have been shown to promote blood clotting [23] and possess antibacterial properties [24, 25]. Other polysaccharides, including chitosan, [26] alginate [27, 28], and cellulose [29], have also been used to fabricate hydrogels and have shown promise as wound healing therapeutics.…”

Section: Reviewmentioning

confidence: 99%

Development and use of biomaterials as wound healing therapies

et al. 2019

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There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.

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Blood-clotting mimetic behavior of biocompatible microgels

Cited by 16 publications

References 36 publications

Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing

Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing

Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Development and use of biomaterials as wound healing therapies

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