Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape

Ilium, Lisbeth; Davis, S.S.; Wilson, C. W. M.; Thomas, N.W.; Frier, M.; Hardy, John G.

doi:10.1016/0378-5173(82)90113-2

Cited by 229 publications

(102 citation statements)

References 10 publications

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“…Rabbits injected with radiolabeled polystyrene particles of different sizes showed rapid deposition of 15.8 um particles in the lungs while 1.27 um particles were deposited mainly in the liver (16). Similar results were obtained when dogs were injected intravenously with radiolabeled microspheres of 3, 5, 7, and 12 um in diameter.…”

Section: Size and Shapesupporting

confidence: 73%

“…As expected, clearance from the bloodstream was size-dependent, with the larger particles clearing first (27). Rabbits injected with 5 um diethylaminoethyl (DEAE) cellulose fibers demonstrated deposition primarily in the lungs, but also in the liver and kidneys (16). Rabbits injected intravenously with 30 um DEAE cellulose fibers died within 4 minutes of administration due to an acute toxic response (tachycardia, dyspnoea, dystaxia) caused by pulmonary emboli (16).…”

Section: Size and Shapementioning

confidence: 99%

“…Rabbits injected with 5 um diethylaminoethyl (DEAE) cellulose fibers demonstrated deposition primarily in the lungs, but also in the liver and kidneys (16). Rabbits injected intravenously with 30 um DEAE cellulose fibers died within 4 minutes of administration due to an acute toxic response (tachycardia, dyspnoea, dystaxia) caused by pulmonary emboli (16). In contrast, 40 to 60 um DEAE cellulose microspheres, although entrapped by the lung, caused no adverse reactions and each of the rabbits injected survived until the completion of the study (16).…”

Section: Size and Shapementioning

confidence: 99%

“…The diameter of capillaries is approximately 6 -8 um. As a result, most particles larger than 6 -8 um will remain in the pulmonary capillaries, with smaller particles passing through the lungs and depositing in organs such as the liver and spleen, where they are processed by phagocytic cells of the reticuloendothelial system (16). Phagocytic overload of the reticuloendothelial system by large numbers of particles has the potential to block the system and lead to secondary infections in a debilitated host (3).…”

Section: Route Of Administrationmentioning

confidence: 99%

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Particulate Matter in Injectable Drug Products

Langille

2013

PDA Journal of Pharmaceutical Science and Technology

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Clinicians have had concerns about particulate matter contamination of injectable drug products since the development of the earliest intravenous therapeutics. All parenteral products contain particulate matter, and particulate matter contamination still has the potential to cause harm to patients. With tens of millions of doses of injectable drug products administered in the United States each year, it is critical to understand the types and sources of particulate matter that contaminate injectable drug products, the possible effects of injected particulate matter on patients, and the current state of regulations and standards related to particulate matter in injectable drug products. Today, the goal of manufacturers, regulators, and standards-setting organizations should be to continue to minimize the risk of particle-induced sequelae, especially in high-risk patients, without trading unnecessary manufacturing burden for minimal safety gains.

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Section: Size and Shapesupporting

confidence: 73%

Section: Size and Shapementioning

confidence: 99%

Section: Size and Shapementioning

confidence: 99%

Section: Route Of Administrationmentioning

confidence: 99%

See 2 more Smart Citations

Particulate Matter in Injectable Drug Products

Langille

2013

PDA Journal of Pharmaceutical Science and Technology

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“…Ilium et al [92] investigated the effects of particle size, shape and nature on blood clearance and organ positioning by injecting spherical particles into animals. Two kinds of particles were used: small (1.27 µm diameter) and large (15.80 µm diameter) polystyrene microspheres and cellulose particles (from 5 to 30 µm).…”

Section: Size and Shapementioning

confidence: 99%

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

Perez

Maiguy-Foinard

Barthélémy

et al. 2016

Pharmaceutical Technology in Hospital Pharmacy

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AbstractOne of the fundamental principles guiding the pharmaceutical quality of parenteral products is to prevent injecting contaminants from microbiological, chemical or physical sources. It is just as difficult to ensure the absence of chemical and particulate contaminants in injectable products as it is to weigh up the microbiological risk. The problem of particulate matter is mainly related to the preparing and administrating of injectable drugs rather than through the contamination of marketed products. Particulate contamination also arises

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Drug-delivery system based on core-shell-type nanoparticles composed of poly(?-benzyl-L-glutamate) and poly(ethylene oxide)

Nah

Jeong

Cho

2000

J. Appl. Polym. Sci.

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A block copolymer based on poly(␥-benzyl-L-glutamate) (PBLG) as the hydrophobic part and poly(ethylene oxide) (PEO) as the hydrophilic part was synthesized and characterized. PBLG/PEO/PBLG (GEG) block copolymer nanoparticles were prepared using the dialysis technique. Fluorescence spectroscopy measurement suggested that GEG block copolymers were associated in water to form polymeric micelles and the critical micelle concentration (CMC) value of the GEG-50 block copolymer was 0.0084 g/L. Particle-size distribution of the GEG-50 block copolymer based on the number average was 34.9 Ϯ 17.6 nm. Also, the particle size and drug-loading contents of GEG nanoparticles were significantly changed with the initial solvent used. From transmission electron microscope (TEM) observations, the GEG polymeric micelle was a nice spherical shape and the sizes ranged from approximately 20 -60 nm in diameter. Results from assessing the drug-loading contents against the initial solvent showed that the use of tetrahydrofuran (THF) or 1,4-dioxane as the initial solvent resulted in higher drug-loading contents than those of other solvents. In the drug-release studies, the higher the molecular weight of the polymer and drug-loading contents, the slower the drug release. Also, the initial solvent used was significantly affected not only in the drug-loading contents but also in the drug-release kinetics.

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Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape

Cited by 229 publications

References 10 publications

Particulate Matter in Injectable Drug Products

Particulate Matter in Injectable Drug Products

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

Drug-delivery system based on core-shell-type nanoparticles composed of poly(?-benzyl-L-glutamate) and poly(ethylene oxide)

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