Blood anticoagulation and antiplatelet activity of green tea (−)-epigallocatechin (EGC) in mice

Chen, Xiaoqiang; Wang, Xianbo; Guan, Rongfa; Tu, Jue; Gong, Zhaohui; Zheng, Na; Yang, Jiehong; Zhang, Yuyan; Ying, Miao-Miao

doi:10.1039/c3fo60088b

Cited by 28 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tea consumption has been shown to be useful for the prevention of many debilitating human diseases. Several published studies have reported similar results to those reported herein, showing that tea consumption can reduce CHD risk [1112]. In our study, we observed that tea consumption was associated with a reduced risk of CHD in female participants, but not in male participants, in Guangzhou, China.…”

Section: Discussionsupporting

confidence: 90%

Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China

Chen

Zhang

et al. 2019

Nutr Res Pract

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES: The association between tea consumption and risk of coronary heart disease (CHD) remains controversial. This study aimed to determine whether tea consumption has an effect on CHD risk in Chinese adults. SUBJECTS/METHODS: In this hospital-based case-control study, 267 cases of CHD and 235 non-CHD controls were enrolled. Blood samples from all cases were examined. Cardiac function indices (left ventricular ejection fraction, left ventricular end-diastolic dimension, lactate dehydrogenase, and creatine kinase of the muscle or brain type), blood lipid index (high-density lipoprotein cholesterol), and blood coagulation function indices (fibrinogen and activated partial thromboplastin time) were recorded. Tea consumption of study participants was assessed by a specifically designed questionnaire. The baseline characteristics of the study populations were recorded, and CHD-related biomarkers were detected. Differences in baseline characteristics of the study participants were examined using t-tests for continuous variables and chi-squared tests for categorical variables. Unconditional logistic regression was used to measure the association between tea and CHD. RESULTS: There were significant differences in cardiac function indices, blood lipid index, and blood coagulation indices between CHD cases and controls (P < 0.05). We found tea consumption reduced CHD risk in female participants (adjusted odds ratio (OR) = 0.484, 95% CI: 0.242-0.968, P = 0.0403). Regarding the type of tea consumed, the risk of CHD was reduced in women who drank partially fermented tea (adjusted OR = 0.210, 95% CI: 0.084-0.522, P = 0.0008). Analytic results for the amount of tea consumed per unit time showed CHD risk was reduced in women who consumed 1-2 cups of tea per day (adjusted OR = 0.291, 95% CI: 0.131-0.643, P = 0.0023). A tea-drinking frequency of > 6 days/week was beneficial for CHD prevention (adjusted OR = 0.183, 95% CI: 0.049-0.679, P = 0.0112). When analyzed according to the duration of tea consumption, the risk of CHD was reduced in participants who had been drinking tea for 10-20 years (adjusted OR = 0.360, 95% CI: 0.137-0.946, P = 0.0382). CONCLUSIONS: Tea consumption is associated with a reduced risk of CHD in female but not male populations in Guangzhou.

show abstract

Section: Discussionsupporting

confidence: 90%

Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China

Chen

Zhang

et al. 2019

Nutr Res Pract

View full text Add to dashboard Cite

show abstract

“…98,99 Regarding quantitative or qualitative platelet changes and hemostasis (bleeding risk), only few information is available, limited to animal studies. Indications on an increased tail bleeding time were made for animals treated with diallyl trisulfides, 121 curcumin, 40,122 epigallocatechin, 123 nobiletin, 124 or chlorogenic acid. 51 Few other papers indicated that phytochemicals can inhibit thrombus formation and platelet function without increased tail bleeding times, i.e., for quercetin, 125 myricetin, 72 and delphinidin glucoside.…”

Section: Implications For Thrombosis and Hemostasismentioning

confidence: 99%

Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis

et al. 2021

View full text Add to dashboard Cite

Cardiovascular disease, in particular due to arterial thrombosis, is a leading cause of mortality and morbidity, with crucial roles of platelets in thrombus formation. For multiple plant-derived phytochemicals found in common dietary components, claims have been made regarding cardiovascular health and antiplatelet activities. Here we present a systematic overview of the published effects of common phytochemicals, applied in vitro or in nutritional intervention studies, on agonist-induced platelet activation properties and platelet signaling pathways. Comparing the phytochemical effects per structural class, we included general phenols: curcuminoids (e.g., curcumin), lignans (honokiol, silybin), phenolic acids (caffeic and chlorogenic acid), derivatives of these (shikimic acid) and stilbenoids (isorhapontigenin, resveratrol). Furthermore, we evaluated the flavonoid polyphenols, including anthocyanidins (delphinidin, malvidin), flavan-3-ols (catechins), flavanones (hesperidin), flavones (apigenin, nobiletin), flavonols (kaempferol, myricetin, quercetin), isoflavones (daidzein, genistein); and terpenoids including carotenes and limonene; and finally miscellaneous compounds like betalains, indoles, organosulfides (diallyl trisulfide) and phytosterols. We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance. Lastly, we provide guidance on which compounds are of interest for further platelet-related research.

show abstract

“…Aglycones act as competitive thrombin inhibitors, while chokeberry extract significantly inhibits thrombin amidolytic activity. (b) FXa inhibition [63][64][65]. Flavonoids: procyanidin B2, cyanidin, quercetin, and silybin bind S1-S4 pockets in vicinity of the FXa active site and block access of substrates to Ser195, thereby directly inhibiting FXa amidolytic activity.…”

Section: Ampk-independent Mechanismsmentioning

confidence: 99%

Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits

Chu¹

2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition, attenuation on mitochondrial respiration, inhibition on xanthine oxidase, and upregulations on endogenous antioxidant enzymes), multiple regulations on cell signaling (e.g.

show abstract

Blood anticoagulation and antiplatelet activity of green tea (−)-epigallocatechin (EGC) in mice

Cited by 28 publications

References 21 publications

Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China

Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China

Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis

Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits

Contact Info

Product

Resources

About