Fei Yue, Wenjiao Li, Jing Zou, Qi Chen, Guibin Xu, Hai Huang, Zhen Xu, Sheng Zhang, Paola Gallinari, Fen Wang, Wallace L. McKeehan, Leyuan Liu
Abstract:Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes with it in cytosolic inclusions. It was suggested HDAC4 interacts with MAP1S in a yeast two-hybrid screening. Here, we found that MAP1S interacts with HDAC4 via a HDAC4-binding domain (HBD). HDAC4 destabilizes MAP1S, supp…
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