volume 5, issue 5, PENEURO.0378-18.2018 2018
DOI: 10.1523/eneuro.0378-18.2018
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Abstract: AbstractMemory formation is a protracted process that initially involves the hippocampus and becomes increasingly dependent on the cortex over time, but the mechanisms of this transfer are unclear. We recently showed that hippocampal depletion of the histone variant H2A.Z enhances both recent and remote memories, but the use of virally mediated depletion reduced H2A.Z levels throughout testing, making its temporally specific function unclear. Given the lack of drugs that target histone variants, we tested exis…

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