Blockage of Axonal Transport in Optic Nerve Induced by Elevation of Intraocular Pressure

Effect of Oral Losartan Potassium Administration on Intraocular Pressure in Normotensive and Glaucomatous Human Subjects

“…The Ang II receptor density is highest in the uveal tract, where the AT1 receptor subtype predominates (480 %) (Ramirez et al, 1996). The blood¯ow to the optic nerve through the posterior ciliary arteries is responsive to Ang II (Sossi and Anderson, 1982;Meyer, Flammer and Luscher, 1995). The vasoconstrictive action of Ang II on the ocular vasculature may shunt blood to the ciliary body.…”

Effect of Oral Losartan Potassium Administration on Intraocular Pressure in Normotensive and Glaucomatous Human Subjects

“…The Ang II receptor density is highest in the uveal tract, where the AT1 receptor subtype predominates (480 %) (Ramirez et al, 1996). The blood¯ow to the optic nerve through the posterior ciliary arteries is responsive to Ang II (Sossi and Anderson, 1982;Meyer, Flammer and Luscher, 1995). The vasoconstrictive action of Ang II on the ocular vasculature may shunt blood to the ciliary body.…”

A Vascular Approach to Glaucoma

“…However, data on these variables is far from consistently pointing them out as risk factors for glaucoma (de Voogd, 2006). Alternatively, or in addition to hypoperfusion, there may be a vascular dysfunction that compromises the normal selfregulating mechanisms of the vessels supplying ONH in response to hypoperfusion (Sossi, 1983). Interestingly, the ONH, due to its unique anatomical condition, is exposed to circulating hormones in a way that the rest of the central nervous system is not.…”

Glaucoma, Capillaries and Pericytes. 3. Peptide Hormone Binding and Influence on Pericytes

“…We looked for evidence that pericytes might be capable of responding to peptide vasoconstrictors [represented by angiotensin II (Ang II)] and vasodilators [represented by vasoactive intestinal peptide (VIP)]. Pep tide effects are of potential importance in the pathogenesis of glaucomatous optic nerve damage in the optic nerve head if, for example, angiotensin can affect the autoregulatory responses of the optic nerve head vasculature [1][2][3], includ ing that o f capillaries.…”

Effect of Oral Losartan Potassium Administration on Intraocular Pressure in Normotensive and Glaucomatous Human Subjects

“…The Ang II receptor density is highest in the uveal tract, where the AT1 receptor subtype predominates (480 %) (Ramirez et al, 1996). The blood¯ow to the optic nerve through the posterior ciliary arteries is responsive to Ang II (Sossi and Anderson, 1982;Meyer, Flammer and Luscher, 1995). The vasoconstrictive action of Ang II on the ocular vasculature may shunt blood to the ciliary body.…”

A Vascular Approach to Glaucoma

“…However, data on these variables is far from consistently pointing them out as risk factors for glaucoma (de Voogd, 2006). Alternatively, or in addition to hypoperfusion, there may be a vascular dysfunction that compromises the normal selfregulating mechanisms of the vessels supplying ONH in response to hypoperfusion (Sossi, 1983). Interestingly, the ONH, due to its unique anatomical condition, is exposed to circulating hormones in a way that the rest of the central nervous system is not.…”

Glaucoma, Capillaries and Pericytes. 3. Peptide Hormone Binding and Influence on Pericytes

“…We looked for evidence that pericytes might be capable of responding to peptide vasoconstrictors [represented by angiotensin II (Ang II)] and vasodilators [represented by vasoactive intestinal peptide (VIP)]. Pep tide effects are of potential importance in the pathogenesis of glaucomatous optic nerve damage in the optic nerve head if, for example, angiotensin can affect the autoregulatory responses of the optic nerve head vasculature [1][2][3], includ ing that o f capillaries.…”

Effect of Oral Losartan Potassium Administration on Intraocular Pressure in Normotensive and Glaucomatous Human Subjects

“…The Ang II receptor density is highest in the uveal tract, where the AT1 receptor subtype predominates (480 %) (Ramirez et al, 1996). The blood¯ow to the optic nerve through the posterior ciliary arteries is responsive to Ang II (Sossi and Anderson, 1982;Meyer, Flammer and Luscher, 1995). The vasoconstrictive action of Ang II on the ocular vasculature may shunt blood to the ciliary body.…”

A Vascular Approach to Glaucoma

“…However, data on these variables is far from consistently pointing them out as risk factors for glaucoma (de Voogd, 2006). Alternatively, or in addition to hypoperfusion, there may be a vascular dysfunction that compromises the normal selfregulating mechanisms of the vessels supplying ONH in response to hypoperfusion (Sossi, 1983). Interestingly, the ONH, due to its unique anatomical condition, is exposed to circulating hormones in a way that the rest of the central nervous system is not.…”

Glaucoma, Capillaries and Pericytes. 3. Peptide Hormone Binding and Influence on Pericytes

“…We looked for evidence that pericytes might be capable of responding to peptide vasoconstrictors [represented by angiotensin II (Ang II)] and vasodilators [represented by vasoactive intestinal peptide (VIP)]. Pep tide effects are of potential importance in the pathogenesis of glaucomatous optic nerve damage in the optic nerve head if, for example, angiotensin can affect the autoregulatory responses of the optic nerve head vasculature [1][2][3], includ ing that o f capillaries.…”