Blockade of Rapid Axonal Transport

Anterior ischaemic optic neuropathy secondary to cluster headache

“…Blockade of both orthograde and retrograde axoplasmic flow at lamina cribrosa also occurs with raised intraocular pressure. The effect can be demonstrated within 1 h by electron microscopy and in 2 h by autoradiography and is rapidly reversible (14). The cause of this block is thought to be mechanical by Minckler et a1 (15), but according to Levy (16).…”

Anterior ischaemic optic neuropathy secondary to cluster headache

“…Blockade of both orthograde and retrograde axoplasmic flow at lamina cribrosa also occurs with raised intraocular pressure. The effect can be demonstrated within 1 h by electron microscopy and in 2 h by autoradiography and is rapidly reversible (14). The cause of this block is thought to be mechanical by Minckler et a1 (15), but according to Levy (16).…”

Transient Optic Disc Swelling After Laser Iridotomy for the Treatment of Acute Angle Closure Glaucoma

“…We speculate that the optic disc swelling was associated with the sudden decrease in the IOP, leading to effusion from the choroidal capillaries in the prelaminar region and its collection in the loose glial tissue [ 6 - 8 ]. Alternatively, the optic disc may have swollen due to an overflow of axoplasmic flow after a sudden drop in the IOP [ 9 ].…”

Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis

“…Prolonged latency has shown to be the most common VEP abnormality in patients with hydrocephalus and idiopathic intracranial hypertension [29,30,31]. It can be explained by the slowing of rapid axoplasmic transport along the visual pathway, because of the raised ICP, as was described in experimental papilledema [32,33], which is analogous to conduction delay along the optic nerve observed in demyelinating disorders [24,34]. In mild cases, this interference with axoplasmic transport will result in a broadening of the pVEP waveform, or grade 2, seen in 10 patients of this cohort.…”

Anterior ischaemic optic neuropathy secondary to cluster headache

“…Blockade of both orthograde and retrograde axoplasmic flow at lamina cribrosa also occurs with raised intraocular pressure. The effect can be demonstrated within 1 h by electron microscopy and in 2 h by autoradiography and is rapidly reversible (14). The cause of this block is thought to be mechanical by Minckler et a1 (15), but according to Levy (16).…”

Transient Optic Disc Swelling After Laser Iridotomy for the Treatment of Acute Angle Closure Glaucoma

“…We speculate that the optic disc swelling was associated with the sudden decrease in the IOP, leading to effusion from the choroidal capillaries in the prelaminar region and its collection in the loose glial tissue [ 6 - 8 ]. Alternatively, the optic disc may have swollen due to an overflow of axoplasmic flow after a sudden drop in the IOP [ 9 ].…”

Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis

“…Prolonged latency has shown to be the most common VEP abnormality in patients with hydrocephalus and idiopathic intracranial hypertension [29,30,31]. It can be explained by the slowing of rapid axoplasmic transport along the visual pathway, because of the raised ICP, as was described in experimental papilledema [32,33], which is analogous to conduction delay along the optic nerve observed in demyelinating disorders [24,34]. In mild cases, this interference with axoplasmic transport will result in a broadening of the pVEP waveform, or grade 2, seen in 10 patients of this cohort.…”

Anterior ischaemic optic neuropathy secondary to cluster headache

“…Blockade of both orthograde and retrograde axoplasmic flow at lamina cribrosa also occurs with raised intraocular pressure. The effect can be demonstrated within 1 h by electron microscopy and in 2 h by autoradiography and is rapidly reversible (14). The cause of this block is thought to be mechanical by Minckler et a1 (15), but according to Levy (16).…”

Transient Optic Disc Swelling After Laser Iridotomy for the Treatment of Acute Angle Closure Glaucoma

“…We speculate that the optic disc swelling was associated with the sudden decrease in the IOP, leading to effusion from the choroidal capillaries in the prelaminar region and its collection in the loose glial tissue [ 6 - 8 ]. Alternatively, the optic disc may have swollen due to an overflow of axoplasmic flow after a sudden drop in the IOP [ 9 ].…”

Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis

“…Prolonged latency has shown to be the most common VEP abnormality in patients with hydrocephalus and idiopathic intracranial hypertension [29,30,31]. It can be explained by the slowing of rapid axoplasmic transport along the visual pathway, because of the raised ICP, as was described in experimental papilledema [32,33], which is analogous to conduction delay along the optic nerve observed in demyelinating disorders [24,34]. In mild cases, this interference with axoplasmic transport will result in a broadening of the pVEP waveform, or grade 2, seen in 10 patients of this cohort.…”