Blockade of orexin receptor 1 attenuates the development of morphine tolerance and physical dependence in rats

Erami, Elaheh; Azhdari-Zarmehri, Hassan; Rahmani, Abolfazl; Ghasemi-Dashkhasan, Elmira; Semnanian, Saeed; Haghparast, Abbas

doi:10.1016/j.pbb.2012.08.010

Cited by 28 publications

(13 citation statements)

References 35 publications

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“…Together with affective changes, physical symptoms have a predictive value for the severity of alcohol withdrawal and the subsequent therapeutic approaches (Jaeger et al, 2001; Wetterling et al, 1997). In rodents, physical signs of withdrawal have been observed after cession of various drugs of abuse, including nicotine, morphine, and cocaine (Erami et al, 2012; Malin et al, 2000; Muldoon et al, 2014; Salas et al, 2007; Salas et al, 2004; Salas et al, 2009). Somatic signs of ethanol withdrawal have also been reported in rats.…”

Section: Discussionmentioning

confidence: 99%

“…We chose to measure signs that are commonly observed in mice undergoing nicotine and morphine withdrawal in addition to the aforementioned signs. Those signs include wet dog shakes, scratching, grooming (including repetitive paw licking and genital licking), chewing, jumping and cage scratching (Erami et al, 2012; Salas et al, 2004). Both ethanol injection and ethanol diet produced a similar increase in total somatic signs during withdrawal, although each treatment led to a different pattern of signs.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of affective and somatic signs of ethanol withdrawal in C57BL/6J mice using a short-term ethanol treatment

Perez

Biasi

2015

Alcohol

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Alcohol is one of the most prevalent addictive substances in the world. Withdrawal symptoms result from abrupt cessation of alcohol consumption in habitual drinkers. The emergence of both affective and physical symptoms produces a state that promotes relapse. Mice provide a preclinical model that could be used to study alcohol dependence and withdrawal while controlling for both genetic and environmental variables. The use of a liquid ethanol diet offers a reliable method for the induction of alcohol dependence in mice, but this approach is impractical when conducting high throughput pharmacological screens or when comparing multiple strains of genetically engineered mice. The goal of this study was to compare withdrawal associated behaviors in mice chronically treated with a liquid ethanol diet vs. mice treated with a short-term ethanol treatment that consisted of daily ethanol injections containing the alcohol dehydrogenase inhibitor, 4-methylpyrazole. Twenty-four hours after ethanol treatment, mice were tested in the open field arena, the elevated plus maze, the marble burying test or for changes in somatic signs during spontaneous ethanol withdrawal. Anxiety-like and compulsive-like behavior, as well as physical signs, were all significantly elevated in mice undergoing withdrawal, regardless of the route of ethanol administration. Therefore, a short-term ethanol treatment can be utilized as a screening tool for testing genetic and pharmacological agents before investing in a more time consuming ethanol treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of affective and somatic signs of ethanol withdrawal in C57BL/6J mice using a short-term ethanol treatment

Perez

Biasi

2015

Alcohol

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“… 9 In recent years, it has been reported that orexins are also involved in the development of antinociceptive tolerance. 10 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

Katayama

Kanada

Tsukada

et al. 2018

Integrative Medicine Research

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BackgroundYokukansan (YKS), a traditional herbal (Kampo) medicine consisting of seven herbs, is effective in the treatment of pain disorders, such as headache, postherpetic neuralgia, fibromyalgia, and trigeminal neuralgia, and we have previously shown it to be effective against morphine analgesic tolerance in rats. It has been reported that orexin receptor antagonists prevent the development of morphine tolerance and that YKS inhibits the secretion of orexin A in the hypothalamus. This study examined whether the inhibition of the secretion of orexin A by YKS is one mechanism underlying its effect against morphine analgesic tolerance.MethodsMale Wistar rats were administered a subcutaneous injection of morphine hydrochloride (10 mg/kg/day) for 5 days. One group was preadministered YKS, starting 3 days before the morphine. The withdrawal latency following thermal stimulation was measured daily using a hot plate test. On day 5, the levels of orexin A in the plasma and the midbrain were measured, and the appearance of activated astrocytes in the midbrain was examined by immunofluorescence staining.ResultsThe preadministration of YKS prevented the development of morphine tolerance. The repeated administration of morphine significantly increased the plasma and midbrain levels of orexin A and the activation of astrocytes. These increases were significantly inhibited by the preadministration of YKS.ConclusionThese results suggest that the preadministration of YKS attenuated the development of antinociceptive morphine tolerance and that the inhibition of orexin A secretion may be one mechanism underlying this phenomenon.

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“…Some behavioral studies have reported that orexin type-1 receptor antagonist SB-334867 inhibits the development of morphine tolerance in rats (Erami et al, 2012;Ranjbar-Slamloo et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Among the major recipients of orexinergic projections is the LC (Nambu et al, 1999) that profusely expresses orexin type-1 receptors (Marcus et al, 2001). Several observations imply that the orexinergic system has been involved in the development of morphine-induced tolerance (Erami et al, 2012;Ranjbar-Slamloo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The role of orexin type-1 receptors in the development of morphine tolerance in locus coeruleus neurons: An electrophysiological perspective

et al. 2016

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Long-term exposure to opioid agonists results in tolerance to their analgesic effects, so the effectiveness of opioid agonists in the management of pain becomes limited. The locus coeruleus (LC) nucleus has been involved in the development of tolerance to opiates. Orexin type-1 receptors (OX1Rs) are highly expressed in LC nucleus. Orexin plays a noteworthy role in the occurrence of morphine tolerance. The purpose of the present study is to investigate the role of orexin type-1 receptors in the development of morphine tolerance in LC neurons. In this study, adult male Wistar rats weighing 250-300g were utilized. Induction of morphine tolerance was obtained by single injection of morphine per day for 6 successive days. An orexin type-1 receptor antagonist (SB-334867) was injected into the lateral ventricle instantly prior to morphine injection. On day 7, the effect of morphine on the electrical activity of LC neurons was studied using in vivo extracellular single unit recording. The results demonstrate that morphine injection for 6 consecutive days led to the development of morphine-induced tolerance in LC neurons. In other words, there was a significant decrease in LC neuronal responsiveness to morphine injection. Inhibitory responses of LC neurons to intraperitoneally applied morphine can be observed with the treatment of the SB-334867 prior to morphine injection. This study showed that OX1R blockade by SB-334867 prevents the development of morphine tolerance in LC neurons. We hope that further studies will lead to considerable progress in understanding the molecular adaptations that contribute to morphine tolerance.

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Blockade of orexin receptor 1 attenuates the development of morphine tolerance and physical dependence in rats

Cited by 28 publications

References 35 publications

Assessment of affective and somatic signs of ethanol withdrawal in C57BL/6J mice using a short-term ethanol treatment

Assessment of affective and somatic signs of ethanol withdrawal in C57BL/6J mice using a short-term ethanol treatment

Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

The role of orexin type-1 receptors in the development of morphine tolerance in locus coeruleus neurons: An electrophysiological perspective

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