Dharm S. Patel, Sarah M. Misenko, Joonyoung Her, Samuel F. Bunting
Abstract:The DNA helicase BLM can have both pro- and anti-recombination effects. Patel et al. show that in cells lacking the homologous recombination repair factors BRCA1, XRCC2, or BRCA2, BLM prevents the assembly of stable RAD51 nucleoprotein filaments, leading to genomic instability and reduced cell viability.
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