Journal of Cell Biology volume 216, issue 11, P3521-3534 2017 DOI: 10.1083/jcb.201703144 View full text
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Dharm S. Patel, Sarah M. Misenko, Joonyoung Her, Samuel F. Bunting

Abstract: The DNA helicase BLM can have both pro- and anti-recombination effects. Patel et al. show that in cells lacking the homologous recombination repair factors BRCA1, XRCC2, or BRCA2, BLM prevents the assembly of stable RAD51 nucleoprotein filaments, leading to genomic instability and reduced cell viability.