Bleomycin Loaded Magnetic Chitosan Nanoparticles as Multifunctional Nanocarriers

Kavaz, Doğa; Odabaş, Sedat; Güven, Eylem; Demirbilek, Murat; Denkbaş, Emir Baki

doi:10.1177/0883911509360735

Cited by 61 publications

(24 citation statements)

References 27 publications

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“…For example, nano-iron has super paramagnetic properties, whereas macro-iron shows only ordinary magnetic properties (40). Nanotechnology plays an important role in different unique ways and has applications in various areas of medicine, as well as biotechnology and agriculture (41).…”

Section: Nanotechnologymentioning

confidence: 99%

Cancer in North Cyprus: 2. Biomedical Research Activities

Djamgoz¹,

Akün²,

Arslan³

et al. 2017

Cyprus J Med Sci

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This is the second part of a two-part review on the cancer status of North Cyprus. Here, we give an overview of the various areas of research on cancer. There are four main areas of ongoing biomedical investigation. First, monitoring of possible carcinogenic chemical factors in the environment (soil and water) is focused on arsenic. Arsenic has been found to exist broadly over the island at levels above the minimum level advised by the Environmental Protection Agency. At present, the source(s) of environmental arsenic is unclear. Second, pathophysiological mechanisms of breast and prostate cancer are being investigated with a focus on ion channels (particularly, the voltage-gated sodium channel) driving the metastatic process. In particular, the triangular relationship involving the channel, its persistent current component, and tumor hypoxia is being elucidated. Third, a further emerging theme is the association of microbiota with cancer. The possible roles of bacterial infections or microbiota in preventing, treating, or causing several types of cancers are among these projects. Fourth, a range of developments in nanotechnology is being considered. It is concluded that the island offers significant opportunities for internationally competitive, multi-faceted research on cancer.

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Section: Nanotechnologymentioning

confidence: 99%

Cancer in North Cyprus: 2. Biomedical Research Activities

Djamgoz¹,

Akün²,

Arslan³

et al. 2017

Cyprus J Med Sci

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“…cDDP-containing nanoparticles were found to be more cytotoxic in resistant and native A2780 cells. Other studies have also reported the release of cisplatin from magnetic nanoparticles [140,141] and other drugs, including bleomycin [142], concanavalin A [142], cyclophosphamide [143] and gemcitabine [144]. …”

Section: Clinical Aspects Of Thermal Potentiation Of Chemotherapeuticmentioning

confidence: 99%

Thermal Potentiation of Chemotherapy by Magnetic Nanoparticles

2013

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Clinical studies have demonstrated the effectiveness of hyperthermia as an adjuvant for chemotherapy and radiotherapy. However, significant clinical challenges have been encountered, such as a broader spectrum of toxicity, lack of patient tolerance, temperature control and significant invasiveness. Hyperthermia induced by magnetic nanoparticles in high-frequency oscillating magnetic fields, commonly termed magnetic fluid hyperthermia, is a promising form of heat delivery in which thermal energy is supplied at the nanoscale to the tumor. This review discusses the mechanisms of heat dissipation of iron oxide-based magnetic nanoparticles, current methods and challenges to deliver heat in the clinic, and the current work related to the use of magnetic nanoparticles for the thermal-chemopotentiation of therapeutic drugs.

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“…So far, several studies have investigated PEGylation of chitosan to improve its affinity to water and organic solvents. Magnetic chitosan nanoparticles, as multifunctional nanocarriers, were loaded with bleomycin and proved to be a very effective as targeting system by Kavaz, Odabas, Güven, Demirbilek, and Denkbas (2010). PEG is a synthetic polymer approved by the FDA for internal consumption and injection in a variety of foods, cosmetics, and drug delivery systems (Cavalla, 2001).…”

Section: In Pharmaceuticsmentioning

confidence: 99%