Bleomycin-Induced “Flagellate Dermatitis”

Flagellate Hyperpigmentation Following Treatment with Low-Dose Bleomycine: Report of two cases

“…The linear or streaked pigmentation usually develops after a cumulative dose between 100-300 U of bleomycin (6,17), whereas considering our cases the cumulative doses were 38 U and 30 U. There are only 17 adult cases of FH following treatment with low-dose bleomycin (Table 1) (2,4,6,8,9,14,15,(17)(18)(19)(20)(21)(22)(25)(26)(27). It is observed that the majority of patients developing FH within 7 days of administration of bleomycin were young adults, even the dose of bleomycin was between 5-30 U.…”

Flagellate dermatitis following consumption of shiitake mushroom

“…Flagellate dermatitis typically presents with multiple intensely pruritic, erythematous linear plaques and papules on the trunk and extremities. 2 Such cutaneous reactions often occurred 48 hours following ingestion of under-cooked or raw shiitake mushroom. 3 The average duration of involvement was 8.5 days and improvement was generally noticed within 2 to 14 days.…”

A pruritic rash in a patient with Hodgkin lymphoma

“…Oral corticosteroids can be used if the response to topical treatment is poor. Avoidance of further exposure to bleomycin is essential, as relapse occurs on re‐exposure, and is often more severe and widespread, 2,5 although no life‐threatening features have been reported. Our patient’s symptoms responded rapidly to topical 0.…”