Blends of synthetic and natural polymers as drug delivery systems for growth hormone

Synthesis and character investigation of new collagen Hydrolysate/polyvinyl alcohol/hydroxyapatite Polymer-Nano-Porous Membranes: I. Experimental design optimization in thermal and structural properties

“…It is reported that the use of COL matrices don't change the phenotypic expression of cultured cells (Reid 1990;Reznnikoff et al 1987;Rocha et al 1985). Combination of COL and watersoluble polymers such as PVA make the blends that can be use as a films, hydrogels or sponges according to our trial and the other study (Cascone et al 1995). This bio artificial material might meet our demands in a range of medical applications including dialysis membranes, wound dressing, artificial skin, cardiovascular devices, nerve guide channels and as implantable devices to release biologically active substances in a controlled manner (Cascone et al 1994;Cascone et al 1995).…”

“…Combination of COL and watersoluble polymers such as PVA make the blends that can be use as a films, hydrogels or sponges according to our trial and the other study (Cascone et al 1995). This bio artificial material might meet our demands in a range of medical applications including dialysis membranes, wound dressing, artificial skin, cardiovascular devices, nerve guide channels and as implantable devices to release biologically active substances in a controlled manner (Cascone et al 1994;Cascone et al 1995). Chemically and physically modified biodegradable polymers such as CH-PVA in this study may be used as scaffolds for tissue engineering purposes.…”

Designing polymeric microparticles for biomedical and industrial applications

“…In fact, synthetic polymers are characterized by their good physicochemical and mechanical properties but they are not sufficiently biocompatible, most likely due to the presence of residues of initiators and other compounds/impurities. On the other hand, natural polymers have good biocompatibility but their mechanical properties are often inadequate [71][72][73]. For chitosan, among the several blends with synthetic polymers described [74], we have been focused on the blending with poly(vinyl alcohol) (PVA).…”

Biomedical Applications of Interpenetrating Polymer Network System

“…IPN based films which are prepared by the mixture of collagen and polyvinyl alcohol, cross-linked with glutaraldehyde vapor shows depot formulation for recombinant human growth hormones [27]. In many animal models, after implantation of transfected cells, a long term expression of the foreign gene has not been achieved [28].…”