Clostridial Diseases of Animals 2016
DOI: 10.1002/9781118728291.ch19
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Blackleg

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Cited by 12 publications
(60 citation statements)
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References 27 publications
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“…In many countries, the use of vaccines to manage BL is recommended for animals aged 2 months to 2 years (Abreu & Uzal ), although in some locations where naturally occurring challenge is particularly high, whole herd clostridial vaccination programmes are required annually or more often (PW, unpublished). The current BL, vaccines when used regularly, are nearly 100% effectives in preventing BL after natural exposure, and 50–100% effective against experimental challenge with C. chauvoei (Uzal ; Abreu et al .…”
Section: Discussionmentioning
confidence: 99%
“…In many countries, the use of vaccines to manage BL is recommended for animals aged 2 months to 2 years (Abreu & Uzal ), although in some locations where naturally occurring challenge is particularly high, whole herd clostridial vaccination programmes are required annually or more often (PW, unpublished). The current BL, vaccines when used regularly, are nearly 100% effectives in preventing BL after natural exposure, and 50–100% effective against experimental challenge with C. chauvoei (Uzal ; Abreu et al .…”
Section: Discussionmentioning
confidence: 99%
“…Blackleg is a clostridial disease characterized by necrotizing myositis and caused by Clostridium chauvoei, which leads to significant economic losses in cattle around the world (Maboni et al 2010, Abreu & Uzal 2016, Abreu et al 2017, including Brazil (Riet-Correa 2007). Although the pathogenesis of blackleg has not been definitely established, current dogma states that the animals become infected by ingesting spores from the pasture.…”
Section: Introductionmentioning
confidence: 99%
“…After one or more replication cycles in the intestine, the spores are absorbed into the systemic circulation and get eventually phagocytized by macrophages within the striated musculature. When a traumatic injury occurs with a consequent decrease in redox potential, the bacteria proliferate and produce several potent toxins that are responsible for the clinical signs and lesions of the disease (Abreu & Uzal 2016, Cooper & Valentine 2016. Because of this proposed pathogenesis, black leg is frequently referred to as an endogenous infection.…”
Section: Introductionmentioning
confidence: 99%
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“…Among different Clostridium spp, Clostridium chauvoei is a highly pathogenic bacterium that causes blackleg or black quarter in cattle, sheep and many other ruminants causing economic losses in livestock (Abreu and Uzal, 1984;Hatheway, 1990). It is the second most important bacterial disease in India next only to haemorrhagic septicaemia in causing death among bovids (Dangi et al, 2014).…”
Section: Introductionmentioning
confidence: 99%