volume 10, issue 11, P3148-3160 2018
DOI: 10.18632/aging.101621
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Isabella Zironi, Entelë Gavoçi, Giovanna Lattanzi, Angela Virelli, Fabrizio Amorini, Daniel Remondini, Gastone Castellani

Abstract: Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder wherein symptoms resembling aspects of aging are manifested at a very early age. It is a genetic condition that occurs due to a de novo mutation in the LMNA gene encoding for the nuclear structural protein lamin A. The lamin family of proteins are thought to be involved in nuclear stability, chromatin structure and gene expression and this leads to heavy effects on the regulation and functionality of the cell machinery. The funct…

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