1995
DOI: 10.1017/s000708740003315x View full text |Buy / Rent full text
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Abstract: Since its inception in World War II, the clinical trial has evolved into a standard procedure in determining therapeutic efficacy. However, the use of comparative statistics in a therapeutic context has a much longer history. Here J. Rosser Matthews discusses three crucial debates: that among clinicians before the Parisian Academy of Medicine in 1837, the debate in the German physiological literature during the 1850s, and, in the early twentieth century, the debate over the bacteriologist's diagnostic techniqu… Show more

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